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Tnfrsf10b
Gene Detail
Symbol

Name
ID
Tnfrsf10b
tumor necrosis factor receptor superfamily, member 10b
MGI:1341090
Synonyms
DR5, KILLER, Killer/Dr5, Ly98, TRAILR2, TRAIL-R2, Trail Receptor, TRICK2A, TRICK2B, TRICKB
Feature Type
protein coding gene
Genetic Map
Chromosome 14
36.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:69767472-69784403 bp, + strand
From Ensembl annotation of GRCm38

  16932 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129806  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle

Protein SuperFamily: TNF-related apoptosis-inducing ligand receptor
Gene Tree: Tnfrsf10b

Human
homologs
Human Homolog TNFRSF10A, tumor necrosis factor receptor superfamily, member 10a
NCBI Gene ID 8797
neXtProt AC  NX_O00220
Human Synonyms  APO2, CD261, DR4, TRAILR1, TRAILR-1
Human Chr (Location)  8p21; chr8:23191457-23225167 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(17) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit enhanced innate immune responses, including increased clearance of cytomegalovirus and increased levels of IL-12, IFN-alpha and IFN-gamma after viral infection.
 
Interactions
Tnfrsf10b interacts with 244 markers (Mir7-1, Mir10a, Mir10b, ...)
Expression
Literature Summary: (5 records)
Data Summary: Results (25)    Tissues (16)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RT-PCR 1
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022074 (Evidence)
Entrez Gene21933 (Evidence)
UniGene193430
DFCITC1585501
DoTSDT.87057899, DT.40175668
NIA Mouse Gene IndexU015811
Consensus CDS ProjectCCDS27243.1
International Mouse Knockout Project StatusTnfrsf10b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022074 Ensembl Gene Model | MGI Sequence Detail 16932 C57BL/6J ±  kb
transcript ENSMUST00000022663 Ensembl | MGI Sequence Detail 3171 Not Applicable 
polypeptide ENSMUSP00000022663 Ensembl | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(95 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR020465 Tumour necrosis factor receptor 10
Protein Ontology PR:000002109 tumor necrosis factor receptor superfamily member 10B
References
(Earliest) J:55627 Wu GS, et al., Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor. Cancer Res. 1999 Jun 15;59(12):2770-5
(Latest) J:209535 Zhu J, et al., TRAIL receptor deficiency sensitizes mice to dextran sodium sulphate-induced colitis and colitis-associated carcinogenesis. Immunology. 2014 Feb;141(2):211-21
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory