Tnfrsf10b
Gene Detail

Symbol Name ID

Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b MGI:1341090

Synonyms

DR5, KILLER, Killer/Dr5, Ly98, TRAILR2, TRAIL-R2, Trail Receptor, TRICK2A, TRICK2B, TRICKB

Feature Type

protein coding gene

Genetic Map

Chromosome 14

36.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr14:69767472-69784403 bp, + strand From Ensembl annotation of GRCm38   16932 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:129806  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: TNF-related apoptosis-inducing ligand receptor
Gene Tree: Tnfrsf10b

Human homologs

Human Homolog		TNFRSF10A, tumor necrosis factor receptor superfamily, member 10a
NCBI Gene ID		8797
neXtProt AC		NX_O00220
Human Synonyms		APO2, CD261, DR4, TRAILR1, TRAILR-1
Human Chr (Location)		8p21; chr8:23048970-23082680 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(23) : Targeted(6) Gene trapped(17)
 

Homozygous mutants exhibit enhanced innate immune responses, including increased clearance of cytomegalovirus and increased levels of IL-12, IFN-alpha and IFN-gamma after viral infection.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component	integral to membrane, membrane
Function	cysteine-type endopeptidase activator activity involved in apoptotic process, TRAIL binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (25)    Tissues (16)    Images (2)
Theiler Stages: 17, 23

Assay Type	Results
RNA in situ	24
RT-PCR	1

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022074 (Evidence)
Entrez Gene	21933 (Evidence)
UniGene	193430
DFCI	TC1585501
DoTS	DT.40175668, DT.87057899
NIA Mouse Gene Index	U015811
Consensus CDS Project	CCDS27243.1
International Mouse Knockout Project Status	Tnfrsf10b

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022074	Ensembl Gene Model | MGI Sequence Detail	16932	C57BL/6J
transcript	ENSMUST00000022663	Ensembl | MGI Sequence Detail	3171	Not Applicable
polypeptide	ENSMUSP00000022663	Ensembl | MGI Sequence Detail	381	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(53 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000488	Death domain
InterPro	IPR011029	Death-like domain
InterPro	IPR001368	TNFR/NGFR cysteine-rich region
InterPro	IPR020465	Tumour necrosis factor receptor 10
Protein Ontology	PR:000002109	tumor necrosis factor receptor superfamily member 10B

References

(Earliest) J:55627 Wu GS, et al., Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor. Cancer Res. 1999 Jun 15;59(12):2770-5
(Latest) J:191015 Wilson NS, et al., Proapoptotic activation of death receptor 5 on tumor endothelial cells disrupts the vasculature and reduces tumor growth. Cancer Cell. 2012 Jul 10;22(1):80-90
All references(57)