About   Help   FAQ
Tnfrsf10b
Gene Detail
Symbol

Name
ID
Tnfrsf10b
tumor necrosis factor receptor superfamily, member 10b
MGI:1341090
Synonyms
DR5, KILLER, Killer/Dr5, Ly98, TRAILR2, TRAIL-R2, Trail Receptor, TRICK2A, TRICK2B, TRICKB
Feature Type
protein coding gene
Genetic Map
Chromosome 14
36.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:69767472-69784403 bp, + strand
From Ensembl annotation of GRCm38

  16932 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129806  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle

HCOP human homology predictions: TNFRSF10A
Protein SuperFamily: TNF-related apoptosis-inducing ligand receptor
Gene Tree: Tnfrsf10b

Human
homologs
TNFRSF10A, tumor necrosis factor receptor superfamily, member 10a
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8797
neXtProt AC: NX_O00220

Human Synonyms: APO2, CD261, DR4, TRAILR1, TRAILR-1

Human Chr (Location): 8p21; chr8:23191457-23225167 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(17) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit enhanced innate immune responses, including increased clearance of cytomegalovirus and increased levels of IL-12, IFN-alpha and IFN-gamma after viral infection.
 
Interactions
Tnfrsf10b interacts with 244 markers (Mir7-1, Mir10a, Mir10b, ...)
Expression
Literature Summary: (5 records)
Data Summary: Results (25)    Tissues (16)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RT-PCR 1
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tnfrsf10b    NEW 
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000022074 (Evidence)
Entrez Gene 21933 (Evidence)
UniGene 193430
DFCI TC1585501
DoTS DT.40175668, DT.87057899
Consensus CDS Project CCDS27243.1
International Mouse Phenotyping Consortium Status Tnfrsf10b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022074 Ensembl Gene Model | MGI Sequence Detail 16932 C57BL/6J ±  kb
transcript ENSMUST00000022663 Ensembl | MGI Sequence Detail 3171 Not Applicable 
polypeptide ENSMUSP00000022663 Ensembl | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(95 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR020465 Tumour necrosis factor receptor 10
Protein Ontology PR:000002109 tumor necrosis factor receptor superfamily member 10B
References
(Earliest) J:55627 Wu GS, et al., Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor. Cancer Res. 1999 Jun 15;59(12):2770-5
(Latest) J:220307 von Karstedt S, et al., Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis. Cancer Cell. 2015 Apr 13;27(4):561-73
All references(59)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory