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Fkbp8 Gene Detail
Summary
  • Symbol
    Fkbp8
  • Name
    FK506 binding protein 8
  • Synonyms
    38kDa, Fkbp38
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341070
    NCBI Gene: 14232
  • Gene Overview
    MyGene.info: FKBP8
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:70527724-70535328 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.15 cM, cytoband C1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341070
protein coding gene Chr8:70527714-70535328 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033711
protein coding gene Chr8:70799979-70807295 (+)
A/J MGP_AJ_G0033694
protein coding gene Chr8:67926015-67933799 (+)
AKR/J MGP_AKRJ_G0033619
protein coding gene Chr8:69857619-69864784 (+)
BALB/cJ MGP_BALBcJ_G0033690
protein coding gene Chr8:68160153-68167409 (+)
C3H/HeJ MGP_C3HHeJ_G0033400
protein coding gene Chr8:70504720-70513167 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034207
protein coding gene Chr8:73477624-73486184 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031151
protein coding gene Chr8:62741123-62749969 (+)
CAST/EiJ MGP_CASTEiJ_G0032725
protein coding gene Chr8:69987065-69995589 (+)
CBA/J MGP_CBAJ_G0033378
protein coding gene Chr8:76115125-76123424 (+)
DBA/2J MGP_DBA2J_G0033532
protein coding gene Chr8:67642381-67649673 (+)
FVB/NJ MGP_FVBNJ_G0033473
protein coding gene Chr8:66761467-66769078 (+)
LP/J MGP_LPJ_G0033619
protein coding gene Chr8:70825571-70834428 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033516
protein coding gene Chr8:78783191-78790507 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034225
protein coding gene Chr8:70042227-70049558 (+)
PWK/PhJ MGP_PWKPhJ_G0032433
protein coding gene Chr8:66942084-66949862 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032269
protein coding gene Chr8:69009099-69016400 (+)
WSB/EiJ MGP_WSBEiJ_G0032840
protein coding gene Chr8:70404496-70411924 (+)



Homology
more
  • Human Ortholog
    FKBP8, FK506 binding protein 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FKBP8, FK506 binding protein 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKBP38, FKBPr38
  • Links
    NCBI Gene ID: 23770
    neXtProt AC: NX_Q14318
    UniProt: Q14318

  • Chr Location
    19p13.11; chr19:18531752-18544077 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7720
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FKBP8
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Fkbp8 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 3 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality, ventralization of neural cell fates, caudal neural tube dilation, and small eyes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019428 Ensembl Gene Model | MGI Sequence Detail 7605 C57BL/6J ±  kb
    transcript ENSMUST00000075491 Ensembl | MGI Sequence Detail 1698 Not Applicable  
    polypeptide ENSMUSP00000074935 Ensembl | MGI Sequence Detail 403 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007544 peptidyl-prolyl cis-trans isomerase FKBP8
    • EC
    • InterPro Domains
      IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
      IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR013026 Tetratricopeptide repeat-containing domain
    Molecular
    Reagents
    less
    • All nucleic 267
      Genomic 1
      cDNA 260
      Primer pair 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:54154 Pedersen KM, et al., muFKBP38: a novel murine immunophilin homolog differentially expressed in Schwannoma cells and central nervous system neurons in vivo. Electrophoresis. 1999 Feb;20(2):249-55
    • Latest
      J:257527 Misaka T, et al., FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice. J Mol Cell Cardiol. 2018 Jan;114:93-104

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory