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Fkbp8
Gene Detail
 Symbol
Name
ID
Fkbp8
FK506 binding protein 8
MGI:1341070
Synonyms 38kDa, Fkbp38
Feature Type protein coding gene
Genetic Map
Chromosome 8
34.15 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:70527724-70535328 bp, + strand
From VEGA annotation of GRCm38

  7605 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7720  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fkbp8

Human
homologs
Human Homolog FKBP8, FK506 binding protein 8, 38kDa
NCBI Gene ID 23770
neXtProt AC  NX_Q14318
Human Synonyms  FKBP38, FKBPr38
Human Chr (Location)  19p12; chr19:18531758-18543573 (-)  GRCh38
Alleles
and
phenotypes
All alleles(32) : Gene trapped(29) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality, ventralization of neural cell fates, caudal neural tube dilation, and small eyes.
 
Human Diseases Modeled Using Mouse Fkbp8 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process apoptotic process, camera-type eye development, ...
Component integral component of endoplasmic reticulum membrane, integral component of membrane, ...
Function FK506 binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (30)    Tissues (5)   
Theiler Stages: 13, 15, 16, 17, 18
Assay TypeResults
RNA in situ 6
Western blot 3
RT-PCR 21
cDNA source data(259)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(266) cDNA(260) Primer pair(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031159 (Evidence)
Ensembl Gene ModelENSMUSG00000019428 (Evidence)
Entrez Gene14232 (Evidence)
UniGene141864
DFCITC1573294, TC1776508
DoTSDT.101124686, DT.110891420, DT.495802, DT.91318893, DT.94301850, DT.99865245, DT.99865248
NIA Mouse Gene IndexU009432
EC5.2.1.8
Consensus CDS ProjectCCDS52575.1, CCDS52576.1
International Mouse Knockout Project StatusFkbp8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031159 VEGA Gene Model | MGI Sequence Detail 7605 C57BL/6J ±  kb
transcript OTTMUST00000077188 VEGA | MGI Sequence Detail 1698 Not Applicable 
polypeptide OTTMUSP00000040763 VEGA | MGI Sequence Detail 403 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(13) UniProt(4)
Polymorphisms SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023114 Elongated TPR repeat-containing domain
InterPro IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
InterPro IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
InterPro IPR001440 Tetratricopeptide TPR-1
Protein Ontology PR:000007544 peptidyl-prolyl cis-trans isomerase FKBP8
References (Earliest) J:54154 Pedersen KM, et al., muFKBP38: a novel murine immunophilin homolog differentially expressed in Schwannoma cells and central nervous system neurons in vivo. Electrophoresis. 1999 Feb;20(2):249-55
(Latest) J:190946 Cabrera RM, et al., Transcriptional analyses of two mouse models of spina bifida. Birth Defects Res A Clin Mol Teratol. 2012 Oct;94(10):782-9
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/01/2014
MGI 5.18
The Jackson Laboratory