Fkbp8
Gene Detail

Symbol Name ID

Fkbp8 FK506 binding protein 8 MGI:1341070

Synonyms

38kDa, Fkbp38

Feature Type

protein coding gene

Genetic Map

Chromosome 8

34.15 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr8:70527724-70535328 bp, + strand From VEGA annotation of GRCm38   7605 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7720  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Fkbp8

Human homologs

Human Homolog		FKBP8, FK506 binding protein 8, 38kDa
NCBI Gene ID		23770
neXtProt AC		NX_Q14318
Human Synonyms		FKBP38, FKBPr38
Human Chr (Location)		19p12; chr19:18642568-18654383 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(32) : Targeted(3) Gene trapped(29)
 

Homozygous null mice display embryonic lethality, ventralization of neural cell fates, caudal neural tube dilation, and small eyes.

 
Human Diseases Modeled Using Mouse Fkbp8 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	apoptotic process, camera-type eye development, ...
Component	integral to endoplasmic reticulum membrane, integral to membrane, ...
Function	FK506 binding, isomerase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (30)    Tissues (5)   
Theiler Stages: 13, 15, 16, 17, 18

Assay Type	Results
RNA in situ	6
Western blot	3
RT-PCR	21

cDNA source data(262)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(269) cDNA(263) Primer pair(6)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000031159 (Evidence)
Ensembl Gene Model	ENSMUSG00000019428 (Evidence)
Entrez Gene	14232 (Evidence)
UniGene	141864
DFCI	TC1573294, TC1776508
DoTS	DT.101124686, DT.110891420, DT.495802, DT.91318893, DT.94301850, DT.99865245, DT.99865248
NIA Mouse Gene Index	U009432
EC	5.2.1.8
Consensus CDS Project	CCDS52575.1, CCDS52576.1
International Mouse Knockout Project Status	Fkbp8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031159	VEGA Gene Model | MGI Sequence Detail	7605	C57BL/6J
transcript	OTTMUST00000077189	VEGA | MGI Sequence Detail	1799	Not Applicable
polypeptide	OTTMUSP00000040764	VEGA | MGI Sequence Detail	403	Not Applicable

All sequences(95) RefSeq(6) UniProt(4)

Polymorphisms

SNPs(13 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023114	Elongated TPR repeat-containing domain
InterPro	IPR023566	Peptidyl-prolyl cis-trans isomerase, FKBP-type
InterPro	IPR001179	Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
InterPro	IPR011990	Tetratricopeptide-like helical
InterPro	IPR019734	Tetratricopeptide repeat
InterPro	IPR013026	Tetratricopeptide repeat-containing domain
InterPro	IPR001440	Tetratricopeptide TPR-1
Protein Ontology	PR:000007544	peptidyl-prolyl cis-trans isomerase FKBP8

References

(Earliest) J:54154 Pedersen KM, et al., muFKBP38: a novel murine immunophilin homolog differentially expressed in Schwannoma cells and central nervous system neurons in vivo. Electrophoresis. 1999 Feb;20(2):249-55
(Latest) J:190946 Cabrera RM, et al., Transcriptional analyses of two mouse models of spina bifida. Birth Defects Res A Clin Mol Teratol. 2012 Oct;94(10):782-9
All references(41)