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Fkbp8 Gene Detail
Summary
  • Symbol
    Fkbp8
  • Name
    FK506 binding protein 8
  • Synonyms
    38kDa, Fkbp38
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341070
    NCBI Gene: 14232
  • Gene Overview
    MyGene.info: FKBP8
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:70527724-70535328 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7605 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.15 cM, cytoband C1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    FKBP8, FK506 binding protein 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FKBP8, FK506 binding protein 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKBP38, FKBPr38
  • Links
    NCBI Gene ID: 23770
    neXtProt AC: NX_Q14318
    UniProt: Q14318

  • Chr Location
    19p13.11; chr19:18531752-18544077 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7720
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FKBP8
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Fkbp8 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 3 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality, ventralization of neural cell fates, caudal neural tube dilation, and small eyes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031159 VEGA Gene Model | MGI Sequence Detail 7605 C57BL/6J ±  kb
    transcript OTTMUST00000077188 VEGA | MGI Sequence Detail 1698 Not Applicable  
    polypeptide OTTMUSP00000040763 VEGA | MGI Sequence Detail 403 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      57 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007544 peptidyl-prolyl cis-trans isomerase FKBP8
    • EC
    • InterPro Domains
      IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
      IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR013026 Tetratricopeptide repeat-containing domain
    Molecular
    Reagents
    less
    • All nucleic 266
      cDNA 260
      Primer pair 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:54154 Pedersen KM, et al., muFKBP38: a novel murine immunophilin homolog differentially expressed in Schwannoma cells and central nervous system neurons in vivo. Electrophoresis. 1999 Feb;20(2):249-55
    • Latest
      J:257527 Misaka T, et al., FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice. J Mol Cell Cardiol. 2018 Jan;114:93-104

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory