About   Help   FAQ
Fcna
Gene Detail
 Symbol
Name
ID
Fcna
ficolin A
MGI:1340905
Synonyms Fcn1, ficolin A
Feature Type protein coding gene
Genetic Map
Chromosome 2
17.58 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:25624666-25628030 bp, - strand
From VEGA annotation of GRCm38

  3365 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:117949  Vertebrate Homology Class
1 mouse; 1 rat

Gene Tree: Fcna

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit normal collagen antibody-induced arthritis.
 
Interactions
Fcna interacts with 19 markers (Mir153, Mir192, Mir207, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process complement activation, lectin pathway, immune system process, ...
Component collagen trimer, extracellular region
Function carbohydrate derivative binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (30)    Tissues (15)   
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 7
RT-PCR 23
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) cDNA(42) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000012513 (Evidence)
Ensembl Gene ModelENSMUSG00000026938 (Evidence)
Entrez Gene14133 (Evidence)
UniGene10510
DFCITC1581192, TC1752118
DoTSDT.493573, DT.55140449
NIA Mouse Gene IndexU022402
Consensus CDS ProjectCCDS15785.1
International Mouse Knockout Project StatusFcna
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012513 VEGA Gene Model | MGI Sequence Detail 3365 C57BL/6J ±  kb
transcript OTTMUST00000029725 VEGA | MGI Sequence Detail 1374 Not Applicable 
polypeptide OTTMUSP00000013369 VEGA | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000007437 ficolin-1
References (Earliest) J:46796 Fujimori Y, et al., Molecular cloning and characterization of mouse ficolin-A. Biochem Biophys Res Commun. 1998 Mar 27;244(3):796-800
(Latest) J:194903 Bidula S, et al., Role of Ficolin-A and Lectin Complement Pathway in the Innate Defense against Pathogenic Aspergillus Species. Infect Immun. 2013 May;81(5):1730-40
All references(30)
Other
accession IDs
MGI:1270842

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory