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Fcna Gene Detail
Summary
  • Symbol
    Fcna
  • Name
    ficolin A
  • Synonyms
    Fcn1, ficolin A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340905
    NCBI Gene: 14133
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25624666-25628030 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 17.58 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340905
protein coding gene Chr2:25624666-25635444 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025461
protein coding gene Chr2:23538088-23541452 (-)
A/J MGP_AJ_G0025438
protein coding gene Chr2:22617140-22620503 (-)
AKR/J MGP_AKRJ_G0025408
protein coding gene Chr2:23381677-23385040 (-)
BALB/cJ MGP_BALBcJ_G0025434
protein coding gene Chr2:22735076-22738442 (-)
C3H/HeJ MGP_C3HHeJ_G0025195
protein coding gene Chr2:23314365-23317729 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025878
protein coding gene Chr2:24275016-24278380 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023289
protein coding gene Chr2:21523417-21526818 (-)
CAST/EiJ MGP_CASTEiJ_G0024658
protein coding gene Chr2:23180671-23185622 (-)
CBA/J MGP_CBAJ_G0025173
protein coding gene Chr2:25115115-25118479 (-)
DBA/2J MGP_DBA2J_G0025306
protein coding gene Chr2:22461597-22464960 (-)
FVB/NJ MGP_FVBNJ_G0025268
protein coding gene Chr2:22208201-22211565 (-)
LP/J MGP_LPJ_G0025392
protein coding gene Chr2:23467228-23470592 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025299
protein coding gene Chr2:25303438-25306801 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025937
protein coding gene Chr2:23337927-23341290 (-)
PWK/PhJ MGP_PWKPhJ_G0024406
protein coding gene Chr2:22275820-22279159 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024206
protein coding gene Chr2:23466489-23469872 (-)
WSB/EiJ MGP_WSBEiJ_G0024727
protein coding gene Chr2:23397580-23400942 (-)



Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal collagen antibody-induced arthritis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026938 Ensembl Gene Model | MGI Sequence Detail 3365 C57BL/6J ±  kb
transcript ENSMUST00000028307 Ensembl | MGI Sequence Detail 1374 Not Applicable  
polypeptide ENSMUSP00000028307 Ensembl | MGI Sequence Detail 334 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007437 ficolin-1
  • InterPro Domains
    IPR008160 Collagen triple helix repeat
    IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
    IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
    IPR020837 Fibrinogen, conserved site
    IPR036056 Fibrinogen-like, C-terminal
Molecular
Reagents
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  • All nucleic 45
    cDNA 43
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1270842
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:46796 Fujimori Y, et al., Molecular cloning and characterization of mouse ficolin-A. Biochem Biophys Res Commun. 1998 Mar 27;244(3):796-800
  • Latest
    J:247271 Yang YF, et al., Ficolin-A/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis. Immunology. 2017 Aug;151(4):433-450

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory