Mice homozygous for targeted mutations that inactivate the gene are viable, females are fertile, but males have severely reduced fertility. Mutant male sperm are defective in sperm-egg membrane adhesion, sperm-egg fusion, migration from the uterus to the oviduct, and binding to the egg zona pellucida.
|InterPro||IPR001762||Blood coagulation inhibitor, Disintegrin|
|InterPro||IPR018358||Disintegrin, conserved site|
|InterPro||IPR000742||Epidermal growth factor-like domain|
|InterPro||IPR024079||Metallopeptidase, catalytic domain|
|InterPro||IPR001590||Peptidase M12B, ADAM/reprolysin|
|InterPro||IPR002870||Peptidase M12B, propeptide|
|Protein Ontology||PR:000003715||disintegrin and metalloproteinase domain-containing protein 2|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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