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Adam2
Gene Detail
 Symbol
Name
ID
Adam2
a disintegrin and metallopeptidase domain 2
MGI:1340894
Synonyms fertilin beta, Ftnb, Ph30-beta
Feature Type protein coding gene
Genetic Map
Chromosome 14
34.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:66027329-66077733 bp, - strand
From NCBI annotation of GRCm38

  50405 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1127  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Adam2

Human
homologs
Human Homolog ADAM2, ADAM metallopeptidase domain 2
NCBI Gene ID 2515
neXtProt AC  NX_Q99965
Human Synonyms  CRYN1, CRYN2, CT15, FTNB, PH30, PH-30b, PH30-beta
Human Chr (Location)  8p11.2; chr8:39743735-39838289 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted mutations that inactivate the gene are viable, females are fertile, but males have severely reduced fertility. Mutant male sperm are defective in sperm-egg membrane adhesion, sperm-egg fusion, migration from the uterus to the oviduct, and binding to the egg zona pellucida.
 
Interactions
Adam2 interacts with 125 markers (Mir7b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process adult behavior, cell adhesion, ...
Component acrosomal vesicle, cell surface, ...
Function metalloendopeptidase activity, metallopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (92)    Tissues (45)    Images (2)
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 92
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(2) cDNA(13) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022039 (Evidence)
Entrez Gene11495 (Evidence)
UniGene422850
DFCITC1586903
DoTSDT.481111, DT.94276933
NIA Mouse Gene IndexU035699
Consensus CDS ProjectCCDS36959.1
International Mouse Knockout Project StatusAdam2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11495 NCBI Gene Model | MGI Sequence Detail 50405 C57BL/6J ±  kb
transcript NM_009618 RefSeq | MGI Sequence Detail 2551 Not Specified 
polypeptide Q60718 UniProt | EBI | MGI Sequence Detail 735 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(144 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006586 ADAM, cysteine-rich
InterPro IPR001762 Blood coagulation inhibitor, Disintegrin
InterPro IPR018358 Disintegrin, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR002870 Peptidase M12B, propeptide
Protein Ontology PR:000003715 disintegrin and metalloproteinase domain-containing protein 2
Graphical View of Protein Domain Structure
References (Earliest) J:25265 Wolfsberg TG, et al., ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain. Dev Biol. 1995 May;169(1):378-83
(Latest) J:180946 Nishimura H, et al., Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins. Reproduction. 2011 Apr;141(4):437-51
All references(60)
Other
accession IDs
MGD-MRK-27045, MGI:104682, MGI:2145619

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory