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Sgk1 Gene Detail
Summary
  • Symbol
    Sgk1
  • Name
    serum/glucocorticoid regulated kinase 1
  • Synonyms
    Sgk, Sgk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340062
    NCBI Gene: 20393
  • Gene Overview
    MyGene.info: SGK1
  • Alliance
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:21882184-21999903 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 9.83 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    808 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340062
protein coding gene Chr10:21882184-21999903 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017063
protein coding gene Chr10:19702347-19823208 (+)
A/J MGP_AJ_G0017041
protein coding gene Chr10:18951756-19070759 (+)
AKR/J MGP_AKRJ_G0017005
protein coding gene Chr10:19285448-19419641 (+)
BALB/cJ MGP_BALBcJ_G0016999
protein coding gene Chr10:19010510-19129906 (+)
C3H/HeJ MGP_C3HHeJ_G0016824
protein coding gene Chr10:19611802-19741560 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017461
protein coding gene Chr10:20209309-20342885 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015166
protein coding gene Chr10:17910778-18027951 (+)
CAST/EiJ MGP_CASTEiJ_G0016406
protein coding gene Chr10:19539173-19665136 (+)
CBA/J MGP_CBAJ_G0016796
protein coding gene Chr10:21134516-21266357 (+)
DBA/2J MGP_DBA2J_G0016904
protein coding gene Chr10:18820695-18940527 (+)
FVB/NJ MGP_FVBNJ_G0016899
protein coding gene Chr10:18564984-18691837 (+)
LP/J MGP_LPJ_G0016979
protein coding gene Chr10:19496496-19617978 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016929
protein coding gene Chr10:21300213-21421784 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017499
protein coding gene Chr10:19272507-19402368 (+)
PWK/PhJ MGP_PWKPhJ_G0016191
protein coding gene Chr10:18742336-18864755 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015974
protein coding gene Chr10:19434526-19559879 (+)
WSB/EiJ MGP_WSBEiJ_G0016468
protein coding gene Chr10:19367664-19489785 (+)



Homology
more
  • Human Ortholog
    SGK1, serum/glucocorticoid regulated kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SGK1, serum/glucocorticoid regulated kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SGK
  • Links
    NCBI Gene ID: 6446
    neXtProt AC: NX_O00141
    UniProt: O00141

  • Chr Location
    6q23.2; chr6:134169246-134318112 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display an essentially normal phenotype. Sodium retention is compromised on a low salt diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20393 NCBI Gene Model | MGI Sequence Detail 117720 C57BL/6J ±  kb
    transcript NM_001161845 RefSeq | MGI Sequence Detail 3121 C57BL/6  
    polypeptide Q9WVC6 UniProt | EBI | MGI Sequence Detail 431 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 217
      cDNA 214
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 12
      Gene Ontology 11
      Phenotypes 48
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:265484 Voelkl J, et al., SGK1 induces vascular smooth muscle cell calcification through NF-kappaB signaling. J Clin Invest. 2018 Jul 2;128(7):3024-3040

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory