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Sgk1 Gene Detail
Summary
  • Symbol
    Sgk1
  • Name
    serum/glucocorticoid regulated kinase 1
  • Synonyms
    Sgk, Sgk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340062
    NCBI Gene: 20393
  • Gene Overview
    MyGene.info: SGK1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:21882184-21999903 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      117720 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 9.83 cM, cytoband A3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SGK1, serum/glucocorticoid regulated kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SGK1, serum/glucocorticoid regulated kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SGK
  • Links
    NCBI Gene ID: 6446
    neXtProt AC: NX_O00141
    UniProt: O00141

  • Chr Location
    6q23.2; chr6:134169246-134318112 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display an essentially normal phenotype. Sodium retention is compromised on a low salt diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031274 VEGA Gene Model | MGI Sequence Detail 117720 C57BL/6J ±  kb
    transcript OTTMUST00000077499 VEGA | MGI Sequence Detail 3096 Not Applicable  
    polypeptide OTTMUSP00000041001 VEGA | MGI Sequence Detail 524 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      808 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 216
      cDNA 213
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 10
      Gene Ontology 10
      Phenotypes 47
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:252305 Orlacchio A, et al., SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance. Cancer Res. 2017 Dec 15;77(24):6914-6926

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/03/2018
    MGI 6.12
    The Jackson Laboratory