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Scml2 Gene Detail
Summary
  • Symbol
    Scml2
  • Name
    sex comb on midleg-like 2 (Drosophila)
  • Synonyms
    4932420G07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340042
    NCBI Gene: 107815
Location & Maps
more
  • Sequence Map
    ChrX:161117193-161258196 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      141004 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 73.95 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SCML2, sex comb on midleg-like 2 (Drosophila)
  • Human Ortholog
    SCML2, sex comb on midleg-like 2 (Drosophila)
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 10389
    neXtProt AC: NX_Q9UQR0

  • Chr Location
    Xp22; chrX:18239313-18354724 (-)  GRCh38.p2

  • HCOP
    human homology predictions: SCML2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Endonuclease-mediated
    2
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Scml2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit male sterility with small testis, impaired differentiation in spermatogenesis and apoptosis of differentiating male germ cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019586 VEGA Gene Model | MGI Sequence Detail 141004 C57BL/6J ±  kb
transcript OTTMUST00000046918 VEGA | MGI Sequence Detail 3550 Not Applicable  
polypeptide OTTMUSP00000021201 VEGA | MGI Sequence Detail 969 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    470 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
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MGI:1921621
References
more
  • Summaries
    All 27
    Developmental Gene Expression 4
    Gene Ontology 1
    Phenotypes 6
  • Earliest
    J:55486 Montini E, et al., Identification of SCML2, a second human gene homologous to the Drosophila sex comb on midleg (Scm): A new gene cluster on Xp22. Genomics. 1999 May 15;58(1):65-72
  • Latest
    J:229091 Branco MR, et al., Maternal DNA Methylation Regulates Early Trophoblast Development. Dev Cell. 2016 Jan 25;36(2):152-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory