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Sema3e Gene Detail
Summary
  • Symbol
    Sema3e
  • Name
    sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
  • Synonyms
    mKIAA0331, Semah
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340034
    NCBI Gene: 20349
Location & Maps
more
  • Sequence Map
    Chr5:14025276-14256689 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      231414 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 5.66 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SEMA3E, semaphorin 3E
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEMA3E, semaphorin 3E
    Orthology source: HGNC, HomoloGene
  • Synonyms
    coll-5, M-SEMAH, M-SemaK, SEMAH
  • Links
    NCBI Gene ID: 9723
    neXtProt AC: NX_O15041

  • Chr Location
    7q21.11; chr7:83363906-83649163 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SEMA3E associations

Human Disease Mouse Models
       CHARGE Syndrome   OMIM: 214800
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    4 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal intersomitic vacular development and loss of the normal segmented somite pattern. Homozygous mutants for another allele have Bergmeister papillae on the surface of the optic disc.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029684 VEGA Gene Model | MGI Sequence Detail 231414 C57BL/6J ±  kb
transcript OTTMUST00000073649 VEGA | MGI Sequence Detail 6861 Not Applicable  
polypeptide OTTMUSP00000038158 VEGA | MGI Sequence Detail 775 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1884 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 33
    cDNA 31
    Primer pair 1
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGI:1097708, MGI:2143468
References
more
  • Summaries
    All 83
    Developmental Gene Expression 34
    Gene Ontology 7
    Phenotypes 25
  • Earliest
    J:46372 Christensen CR, et al., Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines. Cancer Res. 1998 Mar 15;58(6):1238-44
  • Latest
    J:230339 Jiang Q, et al., Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability. Am J Hum Genet. 2015 Apr 2;96(4):581-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory