Sema3e
Gene Detail

Symbol Name ID

Sema3e sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E MGI:1340034

Synonyms

mKIAA0331, Semah

Feature Type

protein coding gene

Genetic Map

Chromosome 5

5.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:14025276-14256689 bp, + strand From VEGA annotation of GRCm38   231414 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Sema3e ± 2 cM)

Protein SuperFamily: semaphorin
Gene Tree: Sema3e

Human ortholog

SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E NCBI Gene ID 9723
Human Synonyms: coll-5, M-SEMAH, M-SemaK, SEMAH
Human Chr7:82993222-83278479 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human SEMA3E (1)

Alleles and phenotypes

All alleles(20) : Targeted(4) Gene trapped(16)
 

Homozygous null mice display abnormal intersomitic vacular development and loss of the normal segmented somite pattern. Homozygous mutants for another allele have Bergmeister papillae on the surface of the optic disc.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	angiogenesis, cell differentiation, ...
Component	extracellular region, membrane
Function	receptor activity

External Resources: FuncBase

Expression

Literature Summary: (24 records)
Data Summary: Results (50)    Tissues (17)    Images (20)
Theiler Stages: 18, 19, 20, 21, 22, 23, 24

Assay Type	Results
RNA in situ	50

cDNA source data(30)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(33) cDNA(31) Primer pair(1) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000029684 (Evidence)
Ensembl Gene Model	ENSMUSG00000063531 (Evidence)
Entrez Gene	20349 (Evidence)
UniGene	134093
DFCI	TC1581886, TC1585973
DoTS	DT.101196631, DT.101232812, DT.101366227, DT.40162002, DT.55158169
NIA Mouse Gene Index	U081385
Consensus CDS Project	CCDS19093.1
International Mouse Knockout Project Status	Sema3e

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029684	VEGA Gene Model | MGI Sequence Detail	231414	C57BL/6J
transcript	OTTMUST00000073649	VEGA | MGI Sequence Detail	6820	Not Applicable
polypeptide	OTTMUSP00000038158	VEGA | MGI Sequence Detail	775	Not Applicable

All sequences(38) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(1540 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013151	Immunoglobulin
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR015513	Semaphorin 3E
InterPro	IPR001627	Semaphorin/CD100 antigen
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000014619	semaphorin-3E

References

(Earliest) J:46372 Christensen CR, et al., Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines. Cancer Res. 1998 Mar 15;58(6):1238-44
(Latest) J:192712 Meadows SM, et al., Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. Circ Res. 2012 Jan 6;110(1):34-46
All references(69)

Other accession IDs

MGI:1097708, MGI:2143468