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Sema3e
Gene Detail
Symbol

Name
ID
Sema3e
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
MGI:1340034
Synonyms
mKIAA0331, Semah
Feature Type
protein coding gene
Genetic Map
Chromosome 5
5.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:14025276-14256689 bp, + strand
From VEGA annotation of GRCm38

  231414 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8247  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: semaphorin
Gene Tree: Sema3e

Human
homologs
Human Homolog SEMA3E, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
NCBI Gene ID 9723
neXtProt AC  NX_O15041
Human Synonyms  coll-5, M-SEMAH, M-SemaK, SEMAH
Human Chr (Location)  7q21.11; chr7:83363906-83649163 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SEMA3E
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(16) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display abnormal intersomitic vacular development and loss of the normal segmented somite pattern. Homozygous mutants for another allele have Bergmeister papillae on the surface of the optic disc.
 
Phenotype Images(4)
Interactions
Sema3e interacts with 363 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process angiogenesis, cell differentiation, ...
Component extracellular region, membrane
Function protein binding, receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (50)    Tissues (17)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 50
cDNA source data(30)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) cDNA(31) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000029684 (Evidence)
Ensembl Gene ModelENSMUSG00000063531 (Evidence)
Entrez Gene20349 (Evidence)
UniGene134093
DFCITC1585973, TC1581886
DoTSDT.101196631, DT.101232812, DT.101366227, DT.40162002, DT.55158169
NIA Mouse Gene IndexU081385
Consensus CDS ProjectCCDS19093.1
International Mouse Knockout Project StatusSema3e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029684 VEGA Gene Model | MGI Sequence Detail 231414 C57BL/6J ±  kb
transcript OTTMUST00000073649 VEGA | MGI Sequence Detail 6820 Not Applicable 
polypeptide OTTMUSP00000038158 VEGA | MGI Sequence Detail 775 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(1888 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1890)
Protein-related
information
ResourceIDDescription
InterPro IPR013151 Immunoglobulin
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR016201 Plexin-like fold
InterPro IPR027231 Semaphorin
InterPro IPR015513 Semaphorin 3E
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000014619 semaphorin-3E
References
(Earliest) J:46372 Christensen CR, et al., Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines. Cancer Res. 1998 Mar 15;58(6):1238-44
(Latest) J:213565 Yagai T, et al., Semaphorin 3E secreted by damaged hepatocytes regulates the sinusoidal regeneration and liver fibrosis during liver regeneration. Am J Pathol. 2014 Aug;184(8):2250-9
All references(82)
Other
accession IDs
MGI:1097708, MGI:2143468

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory