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Nfkbil1 Gene Detail
Summary
  • Symbol
    Nfkbil1
  • Name
    nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1
  • Synonyms
    Def-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340031
    NCBI Gene: 18038
  • Gene Overview
    MyGene.info: NFKBIL1
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35220175-35235792 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.60 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340031
 protein coding gene Chr17:35220175-35236476 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023630
 protein coding gene Chr17:35371643-35387260 (-)
A/J MGP_AJ_G0023589
 protein coding gene Chr17:34190262-34205959 (-)
AKR/J MGP_AKRJ_G0023558
 protein coding gene Chr17:34671205-34686095 (-)
BALB/cJ MGP_BALBcJ_G0023596
 protein coding gene Chr17:34335750-34351449 (-)
C3H/HeJ MGP_C3HHeJ_G0023357
 protein coding gene Chr17:35076596-35091484 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024035
 protein coding gene Chr17:36727034-36742660 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021516
 protein coding gene Chr17:31962209-31978345 (-)
CAST/EiJ MGP_CASTEiJ_G0022853
 protein coding gene Chr17:35082746-35100551 (-)
CBA/J MGP_CBAJ_G0023335
 protein coding gene Chr17:38229774-38244662 (-)
DBA/2J MGP_DBA2J_G0023463
 protein coding gene Chr17:33517542-33533225 (-)
FVB/NJ MGP_FVBNJ_G0023430
 protein coding gene Chr17:33360515-33375340 (-)
LP/J MGP_LPJ_G0023540
 protein coding gene Chr17:35700983-35716602 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023452
 protein coding gene Chr17:37156435-37172044 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024080
 protein coding gene Chr17:34900819-34916361 (-)
PWK/PhJ MGP_PWKPhJ_G0022601
 protein coding gene Chr17:32358298-32374296 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022421
 protein coding gene Chr17:32909636-32925171 (-)
WSB/EiJ MGP_WSBEiJ_G0022917
 protein coding gene Chr17:35029736-35045428 (-)



Homology
more
  • Human Ortholog
    NFKBIL1, NFKB inhibitor like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NFKBIL1, NFKB inhibitor like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IKBL, NFKBIL
  • Links
    NCBI Gene ID: 4795
    neXtProt AC: NX_Q9UBC1
    UniProt: Q9UBC1

  • Chr Location
    6p21.33; chr6:31546851-31558829 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human NFKBIL1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    7
  • Tissues
    7
  • cDNA Data
    17
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042419 Ensembl Gene Model | MGI Sequence Detail 15618 C57BL/6J ±  kb
    transcript ENSMUST00000048994 Ensembl | MGI Sequence Detail 1447 Not Applicable  
    polypeptide ENSMUSP00000035452 Ensembl | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 6
      cDNA 17
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:53338 Handel-Fernandez ME, et al., Sequence analysis and expression of a mouse homolog of human IkappaBL gene. Biochim Biophys Acta. 1999 Feb 16;1444(2):306-10
    • Latest
      J:236041 McIntyre RE, et al., A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice. G3 (Bethesda). 2016 Aug 09;6(8):2343-54
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    01/15/2019
    MGI 6.13     		The Jackson Laboratory