Nfkbil1 MGI Mouse Gene Detail - MGI:1340031 - nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1

Nfkbil1 Gene Detail

Symbol

Nfkbil1
Name

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1
Synonyms

Def-7

Feature Type

protein coding gene
IDs

MGI:1340031
NCBI Gene: 18038
Gene Overview

MyGene.info: NFKBIL1

Sequence Map

Chr17:35220175-35235792 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

15618 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.60 cM
Mapping Data

1 experiment

Human Ortholog

NFKBIL1, NFKB inhibitor like 1

Vertebrate Orthologs

9

Human Ortholog

NFKBIL1, NFKB inhibitor like 1
Orthology source: HomoloGene, HGNC
Synonyms

IKBL, LST1, NFKBIL
Links

HGNC:7800

NCBI Gene ID: 4795

neXtProt AC: NX_Q9UBC1

UniProt: Q9UBC1
Chr Location

6p21.33; chr6:31546851-31558829 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 3671
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NFKBIL1
Gene Tree

Nfkbil1

Diseases

1 with human NFKBIL1 associations

				Human Disease	Mouse Models
				rheumatoid arthritis IDs rheumatoid arthritis DOID:7148 EFO:0000685 ICD10CM:M06.9 ICD9CM:714.0 KEGG:05323 MESH:D001172 NCI:C27206 NCI:C2884 OMIM:180300 UMLS_CUI:C0003873

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Gene trapped

8
Targeted

3
Genomic Mutations

1 involving Nfkbil1
Incidental Mutations

CvDC
Find Mice (IMSR)

11 strains or lines available

less

All GO Annotations

10
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

7
Tissues

7
cDNA Data

16
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

Nfkbil1 interacts with 31 markers (Mir26a-1, Mir34a, Mir140, ...) View All

less

All Sequences

20
RefSeq

4
UniProt

2
CCDS

CCDS28693.1
UniGene

300795

			Length	Strain/Species	Flank
genomic	OTTMUSG00000031450	VEGA Gene Model \| MGI Sequence Detail	15618	C57BL/6J	± kb
transcript	OTTMUST00000077934	VEGA \| MGI Sequence Detail	1447	Not Applicable
polypeptide	OTTMUSP00000041325	VEGA \| MGI Sequence Detail	381	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000011180 NF-kappa-B inhibitor-like protein 1

(term hierarchy)
InterPro Domains

IPR020683 Ankyrin repeat-containing domain

less

All nucleic 23

Genomic 6

cDNA 16

Primer pair 1

Microarray probesets 2

Summaries

All 33

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 10
Earliest

J:53338 Handel-Fernandez ME, et al., Sequence analysis and expression of a mouse homolog of human IkappaBL gene. Biochim Biophys Acta. 1999 Feb 16;1444(2):306-10
Latest

J:236041 McIntyre RE, et al., A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice. G3 (Bethesda). 2016 Aug 09;6(8):2343-54

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/12/2017 MGI 6.10