Nfkbil1 MGI Mouse Gene Detail - MGI:1340031 - nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1

Symbol

Nfkbil1
Name

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1
Synonyms

Def-7

Feature Type

protein coding gene
IDs

MGI:1340031
NCBI Gene: 18038
Gene Overview

MyGene.info: NFKBIL1
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:35220175-35235792 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.60 cM
Mapping Data

1 experiment

Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1340031	protein coding gene	Chr17:35220175-35236476 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023630	protein coding gene	Chr17:35371643-35387260 (-)
A/J	MGP_AJ_G0023589	protein coding gene	Chr17:34190262-34205959 (-)
AKR/J	MGP_AKRJ_G0023558	protein coding gene	Chr17:34671205-34686095 (-)
BALB/cJ	MGP_BALBcJ_G0023596	protein coding gene	Chr17:34335750-34351449 (-)
C3H/HeJ	MGP_C3HHeJ_G0023357	protein coding gene	Chr17:35076596-35091484 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024035	protein coding gene	Chr17:36727034-36742660 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021516	protein coding gene	Chr17:31962209-31978345 (-)
CAST/EiJ	MGP_CASTEiJ_G0022853	protein coding gene	Chr17:35082746-35100551 (-)
CBA/J	MGP_CBAJ_G0023335	protein coding gene	Chr17:38229774-38244662 (-)
DBA/2J	MGP_DBA2J_G0023463	protein coding gene	Chr17:33517542-33533225 (-)
FVB/NJ	MGP_FVBNJ_G0023430	protein coding gene	Chr17:33360515-33375340 (-)
LP/J	MGP_LPJ_G0023540	protein coding gene	Chr17:35700983-35716602 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023452	protein coding gene	Chr17:37156435-37172044 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024080	protein coding gene	Chr17:34900819-34916361 (-)
PWK/PhJ	MGP_PWKPhJ_G0022601	protein coding gene	Chr17:32358298-32374296 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022421	protein coding gene	Chr17:32909636-32925171 (-)
WSB/EiJ	MGP_WSBEiJ_G0022917	protein coding gene	Chr17:35029736-35045428 (-)

Human Ortholog

NFKBIL1, NFKB inhibitor like 1

Vertebrate Orthologs

9

Human Ortholog

NFKBIL1, NFKB inhibitor like 1
Orthology source: HomoloGene, HGNC
Synonyms

IKBL, NFKBIL
Links

HGNC:7800

NCBI Gene ID: 4795

neXtProt AC: NX_Q9UBC1

UniProt: Q9UBC1
Chr Location

6p21.33; chr6:31546851-31558829 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 3671
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NFKBIL1
Gene Tree

Nfkbil1

Diseases

1 with human NFKBIL1 associations

				Human Disease	Mouse Models
				rheumatoid arthritis IDs rheumatoid arthritis DOID:7148 EFO:0000685 ICD10CM:M06.9 ICD9CM:714.0 KEGG:05323 MESH:D001172 NCI:C2884 OMIM:180300 UMLS_CUI:C0003873

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Gene trapped

8
Targeted

3
Genomic Mutations

1 involving Nfkbil1
Incidental Mutations

CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

7
Tissues

7
cDNA Data

17
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nfkbil1

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Nfkbil1 interacts with 31 markers (Mir26a-1, Mir34a, Mir140, ...) View All

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All Sequences

34
RefSeq

4
UniProt

2
CCDS

CCDS28693.1
UniGene

300795

Ensembl

ENSMUSG00000042419 (Evidence)
NCBI Gene

18038 (Evidence)

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042419	Ensembl Gene Model \| MGI Sequence Detail	15618	C57BL/6J	± kb
transcript	ENSMUST00000048994	Ensembl \| MGI Sequence Detail	1447	Not Applicable
polypeptide	ENSMUSP00000035452	Ensembl \| MGI Sequence Detail	381	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011180 NF-kappa-B inhibitor-like protein 1

(term hierarchy)
InterPro Domains

IPR020683 Ankyrin repeat-containing domain

IPR036770 Ankyrin repeat-containing domain superfamily

IPR038753 NF-kappa-B inhibitor-like protein 1

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All nucleic 24

Genomic 6

cDNA 17

Primer pair 1

Microarray probesets 2

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 10
Earliest

J:53338 Handel-Fernandez ME, et al., Sequence analysis and expression of a mouse homolog of human IkappaBL gene. Biochim Biophys Acta. 1999 Feb 16;1444(2):306-10
Latest

J:236041 McIntyre RE, et al., A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice. G3 (Bethesda). 2016 Aug 09;6(8):2343-54

TSS for Nfkbil1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147826	Chr17:35235755-35235817 (-)	6 bp
Tssr147825	Chr17:35235735-35235742 (-)	53 bp
Tssr147824	Chr17:35235693-35235709 (-)	91 bp
Tssr147823	Chr17:35235215-35235260 (-)	554 bp
Tssr147822	Chr17:35234996-35235034 (-)	777 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/06/2018 MGI 6.13