About   Help   FAQ
Crlf1
Gene Detail
Symbol

Name
ID
Crlf1
cytokine receptor-like factor 1
MGI:1340030
Synonyms
CLF-1, CRLM3, cytokine receptor like molecule 3
Feature Type
protein coding gene
Genetic Map
Chromosome 8
34.15 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:70493158-70504081 bp, + strand
From VEGA annotation of GRCm38

  10924 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3489  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CRLF1
Gene Tree: Crlf1

Human
homologs
CRLF1, cytokine receptor-like factor 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9244
neXtProt AC: NX_O75462

Human Synonyms: CISS, CISS1, CLF, CLF-1, NR6, zcytor5

Human Chr (Location): 19p12; chr19:18593225-18606850 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CRLF1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted mutation fail to suckle effectively and do not survive beyond 24 hrs after birth. Newborns exhibit reduced numbers of hematopoietic progenitor cells as well as a significant reduction in the number of motoneurons in the lumbar spinal cord and facial nucleus.
 
Interactions
Crlf1 interacts with 31 markers (Mir28b, Mir28c, Mir105, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (194)    Tissues (67)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 176
RT-PCR 18
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase crlf1 ; ZFIN crlf1a, crlf1b    NEW 
Molecular
reagents
All nucleic(35) cDNA(31) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000033461 (Evidence)
Ensembl Gene Model ENSMUSG00000007888 (Evidence)
Entrez Gene 12931 (Evidence)
UniGene 335584
DFCI TC1583104
DoTS DT.110875661, DT.529872
NIA Mouse Gene Index U254710
Consensus CDS Project CCDS22369.1
International Mouse Phenotyping Consortium Status Crlf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033461 VEGA Gene Model | MGI Sequence Detail 10924 C57BL/6J ±  kb
transcript OTTMUST00000084076 VEGA | MGI Sequence Detail 1644 Not Applicable 
polypeptide OTTMUSP00000045254 VEGA | MGI Sequence Detail 425 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(8) UniProt(6)
Polymorphisms
SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR015152 Growth hormone/erythropoietin receptor, ligand binding
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000005885 cytokine receptor-like factor 1
References
(Earliest) J:61516 Elson GC, et al., Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family. J Immunol. 1998 Aug 1;161(3):1371-9
(Latest) J:220461 Kann M, et al., WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals. Development. 2015 Apr 1;142(7):1254-66
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory