Crlf1
Gene Detail

Symbol Name ID

Crlf1 cytokine receptor-like factor 1 MGI:1340030

Synonyms

CLF-1, CRLM3, cytokine receptor like molecule 3

Feature Type

protein coding gene

Genetic Map

Chromosome 8

34.15 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:70493158-70504081 bp, + strand From VEGA annotation of GRCm38   10924 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3489  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Crlf1

Human homologs

Human Homolog		CRLF1, cytokine receptor-like factor 1
NCBI Gene ID		9244
neXtProt AC		NX_O75462
Human Synonyms		CISS, CISS1, CLF, CLF-1, NR6, zcytor5
Human Chr (Location)		19p12; chr19:18704035-18717660 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CRLF1

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(2)
 

Mice homozygous for a targeted mutation fail to suckle effectively and do not survive beyond 24 hrs after birth. Newborns exhibit reduced numbers of hematopoietic progenitor cells as well as a significant reduction in the number of motoneurons in the lumbar spinal cord and facial nucleus.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	negative regulation of motor neuron apoptotic process, negative regulation of neuron apoptotic process, ...
Component	CRLF-CLCF1 complex, cytoplasm, ...
Function	ciliary neurotrophic factor receptor binding, cytokine activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (193)    Tissues (67)    Images (38)
Theiler Stages: 19, 20, 22, 23, 24, 26

Assay Type	Results
RNA in situ	175
RT-PCR	18

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(35) cDNA(31) Primer pair(3) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000033461 (Evidence)
Ensembl Gene Model	ENSMUSG00000007888 (Evidence)
Entrez Gene	12931 (Evidence)
UniGene	335584
DFCI	TC1583104
DoTS	DT.110875661, DT.529872
NIA Mouse Gene Index	U254710
Consensus CDS Project	CCDS22369.1
International Mouse Knockout Project Status	Crlf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033461	VEGA Gene Model | MGI Sequence Detail	10924	C57BL/6J
transcript	OTTMUST00000084076	VEGA | MGI Sequence Detail	1644	Not Applicable
polypeptide	OTTMUSP00000045254	VEGA | MGI Sequence Detail	425	Not Applicable

All sequences(44) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(21 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR015152	Growth hormone/erythropoietin receptor, ligand binding
InterPro	IPR013783	Immunoglobulin-like fold
Protein Ontology	PR:000005885	cytokine receptor-like factor 1

References

(Earliest) J:61516 Elson GC, et al., Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family. J Immunol. 1998 Aug 1;161(3):1371-9
(Latest) J:183382 Kass DJ, et al., Cytokine-Like Factor 1 Gene Expression Is Enriched in Idiopathic Pulmonary Fibrosis and Drives the Accumulation of CD4(+) T Cells in Murine Lungs: Evidence for an Antifibrotic Role in Bleomycin Injury. Am J Pathol. 2012 May;180(5):1963-78
All references(43)