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Crlf1
Gene Detail
 Symbol
Name
ID
Crlf1
cytokine receptor-like factor 1
MGI:1340030
Synonyms CLF-1, CRLM3, cytokine receptor like molecule 3
Feature Type protein coding gene
Genetic Map
Chromosome 8
34.15 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:70493158-70504081 bp, + strand
From VEGA annotation of GRCm38

  10924 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3489  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Crlf1

Human
homologs
Human Homolog CRLF1, cytokine receptor-like factor 1
NCBI Gene ID 9244
neXtProt AC  NX_O75462
Human Synonyms  CISS, CISS1, CLF, CLF-1, NR6, zcytor5
Human Chr (Location)  19p12; chr19:18593225-18606850 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CRLF1
Alleles
and
phenotypes
All alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation fail to suckle effectively and do not survive beyond 24 hrs after birth. Newborns exhibit reduced numbers of hematopoietic progenitor cells as well as a significant reduction in the number of motoneurons in the lumbar spinal cord and facial nucleus.
 
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process negative regulation of motor neuron apoptotic process, negative regulation of neuron apoptotic process, ...
Component CRLF-CLCF1 complex, extracellular region
Function ciliary neurotrophic factor receptor binding, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (194)    Tissues (67)    Images (39)
Theiler Stages: 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 176
RT-PCR 18
cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(35) cDNA(31) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000033461 (Evidence)
Ensembl Gene ModelENSMUSG00000007888 (Evidence)
Entrez Gene12931 (Evidence)
UniGene335584
DFCITC1583104
DoTSDT.110875661, DT.529872
NIA Mouse Gene IndexU254710
Consensus CDS ProjectCCDS22369.1
International Mouse Knockout Project StatusCrlf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033461 VEGA Gene Model | MGI Sequence Detail 10924 C57BL/6J ±  kb
transcript OTTMUST00000084076 VEGA | MGI Sequence Detail 1644 Not Applicable 
polypeptide OTTMUSP00000045254 VEGA | MGI Sequence Detail 425 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(8) UniProt(6)
Polymorphisms SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR015152 Growth hormone/erythropoietin receptor, ligand binding
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000005885 cytokine receptor-like factor 1
References (Earliest) J:61516 Elson GC, et al., Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family. J Immunol. 1998 Aug 1;161(3):1371-9
(Latest) J:183382 Kass DJ, et al., Cytokine-Like Factor 1 Gene Expression Is Enriched in Idiopathic Pulmonary Fibrosis and Drives the Accumulation of CD4(+) T Cells in Murine Lungs: Evidence for an Antifibrotic Role in Bleomycin Injury. Am J Pathol. 2012 May;180(5):1963-78
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory