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Crlf1 Gene Detail
Summary
  • Symbol
    Crlf1
  • Name
    cytokine receptor-like factor 1
  • Synonyms
    CLF-1, CRLM3, cytokine receptor like molecule 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340030
    NCBI Gene: 12931
  • Gene Overview
    MyGene.info: CRLF1
Location & Maps
more
  • Sequence Map
    Chr8:70493158-70504081 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10924 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CRLF1, cytokine receptor-like factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRLF1, cytokine receptor-like factor 1
    Orthology source: HomoloGene
  • Synonyms
    CISS, CISS1, CLF, CLF-1, NR6, zcytor5
  • Links
    NCBI Gene ID: 9244
    neXtProt AC: NX_O75462

  • Chr Location
    19p12; chr19:18593225-18606850 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3489
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CRLF1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CRLF1 associations

Human Disease Mouse Models
       Cold-Induced Sweating Syndrome 1; CISS1   OMIM: 272430
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    2
  • Genomic Mutations
    1 involving Crlf1
  • Incidental Mutations
Mice homozygous for a targeted mutation fail to suckle effectively and do not survive beyond 24 hrs after birth. Newborns exhibit reduced numbers of hematopoietic progenitor cells as well as a significant reduction in the number of motoneurons in the lumbar spinal cord and facial nucleus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033461 VEGA Gene Model | MGI Sequence Detail 10924 C57BL/6J ±  kb
transcript OTTMUST00000084076 VEGA | MGI Sequence Detail 1644 Not Applicable  
polypeptide OTTMUSP00000045254 VEGA | MGI Sequence Detail 425 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    32 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000005885 cytokine receptor-like factor 1
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR015152 Growth hormone/erythropoietin receptor, ligand binding
    IPR010457 Immunoglobulin C2-set-like, ligand-binding
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
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  • All nucleic 35
    cDNA 31
    Primer pair 3
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 41
    Developmental Gene Expression 12
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:61516 Elson GC, et al., Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family. J Immunol. 1998 Aug 1;161(3):1371-9
  • Latest
    J:224142 Reginensi A, et al., Yap and Taz are required for Ret-dependent urinary tract morphogenesis. Development. 2015 Aug 1;142(15):2696-703

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory