Mice homozygous for a targeted mutation fail to suckle effectively and do not survive beyond 24 hrs after birth. Newborns exhibit reduced numbers of hematopoietic progenitor cells as well as a significant reduction in the number of motoneurons in the lumbar spinal cord and facial nucleus.
|Process||negative regulation of motor neuron apoptotic process, negative regulation of neuron apoptotic process, ...|
|Component||CRLF-CLCF1 complex, extracellular region|
|Function||ciliary neurotrophic factor receptor binding, cytokine activity, ...|
|VEGA Gene Model||OTTMUSG00000033461 (Evidence)|
|Ensembl Gene Model||ENSMUSG00000007888 (Evidence)|
|Entrez Gene||12931 (Evidence)|
|NIA Mouse Gene Index||U254710|
|Consensus CDS Project||CCDS22369.1|
|International Mouse Phenotyping Consortium Status||Crlf1|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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