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Aldh1l1 Gene Detail
Summary
  • Symbol
    Aldh1l1
  • Name
    aldehyde dehydrogenase 1 family, member L1
  • Synonyms
    1810048F20Rik, Fthfd
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340024
    NCBI Gene: 107747
  • Gene Overview
    MyGene.info: ALDH1L1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:90550793-90599171 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 40.16 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    405 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1340024
protein coding gene Chr6:90486427-90600203 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031039
protein coding gene Chr6:92018786-92146711 (+)
A/J MGP_AJ_G0031007
protein coding gene Chr6:88518416-88636231 (+)
AKR/J MGP_AKRJ_G0030939
protein coding gene Chr6:90996671-91109493 (+)
BALB/cJ MGP_BALBcJ_G0031019
protein coding gene Chr6:88464632-88585974 (+)
C3H/HeJ MGP_C3HHeJ_G0030689
protein coding gene Chr6:93336684-93452357 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031478
protein coding gene Chr6:94443921-94566158 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028647
protein coding gene Chr6:86573750-86621578 (+)
CAST/EiJ MGP_CASTEiJ_G0030126
protein coding gene Chr6:91101731-91219506 (+)
CBA/J MGP_CBAJ_G0030705
protein coding gene Chr6:97971926-98098936 (+)
DBA/2J MGP_DBA2J_G0030858
protein coding gene Chr6:87711908-87827662 (+)
FVB/NJ MGP_FVBNJ_G0030812
protein coding gene Chr6:86912869-87026580 (+)
LP/J MGP_LPJ_G0030938
protein coding gene Chr6:91995129-92114971 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030846
protein coding gene Chr6:102056234-102175776 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031505
protein coding gene Chr6:90831124-90948634 (+)
PWK/PhJ MGP_PWKPhJ_G0029842
protein coding gene Chr6:86656691-86772335 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029671
protein coding gene Chr6:89728612-89851973 (+)
WSB/EiJ MGP_WSBEiJ_G0030210
protein coding gene Chr6:91297868-91412812 (+)



Homology
more
  • Human Ortholog
    ALDH1L1, aldehyde dehydrogenase 1 family member L1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ALDH1L1, aldehyde dehydrogenase 1 family member L1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    10-fTHF, 10-FTHFDH, FDH, FTHFD
  • Links
    NCBI Gene ID: 10840
    neXtProt AC: NX_O75891
    UniProt: O75891

  • Chr Location
    3q21.3; chr3:126103561-126181526 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 107747 NCBI Gene Model | MGI Sequence Detail 48379 C57BL/6J ±  kb
transcript NM_027406 RefSeq | MGI Sequence Detail 3139 C57BL/6  
polypeptide Q8R0Y6 UniProt | EBI | MGI Sequence Detail 902 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000003924 10-formyltetrahydrofolate dehydrogenase
  • EC
  • InterPro Domains
    IPR011407 10-formyltetrahydrofolate dehydrogenase
    IPR036736 ACP-like superfamily
    IPR016163 Aldehyde dehydrogenase, C-terminal
    IPR016160 Aldehyde dehydrogenase, cysteine active site
    IPR015590 Aldehyde dehydrogenase domain
    IPR029510 Aldehyde dehydrogenase, glutamic acid active site
    IPR016162 Aldehyde dehydrogenase, N-terminal
    IPR016161 Aldehyde/histidinol dehydrogenase
    IPR005793 Formyl transferase, C-terminal
    IPR037022 Formyl transferase, C-terminal domain superfamily
    IPR011034 Formyl transferase-like, C-terminal domain superfamily
    IPR002376 Formyl transferase, N-terminal
    IPR036477 Formyl transferase, N-terminal domain superfamily
    IPR009081 Phosphopantetheine binding ACP domain
    IPR001555 Phosphoribosylglycinamide formyltransferase, active site
Molecular
Reagents
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  • All nucleic 151
    cDNA 150
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1917624
References
more
  • Summaries
    All 67
    Developmental Gene Expression 23
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:21726 Champion KM, et al., Identification of a heritable deficiency of the folate-dependent enzyme 10-formyltetrahydrofolate dehydrogenase in mice. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11338-42
  • Latest
    J:262410 Tanabe S, et al., B-1a lymphocytes promote oligodendrogenesis during brain development. Nat Neurosci. 2018 Apr;21(4):506-516

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory