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Aldh1l1 Gene Detail
Summary
  • Symbol
    Aldh1l1
  • Name
    aldehyde dehydrogenase 1 family, member L1
  • Synonyms
    1810048F20Rik, Fthfd
  • Feature Type
    protein coding gene
  • IDs
    MGI:1340024
    NCBI Gene: 107747
  • Gene Overview
    MyGene.info: ALDH1L1
Location & Maps
more
  • Sequence Map
    Chr6:90486427-90600203 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      113777 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 40.16 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ALDH1L1, aldehyde dehydrogenase 1 family member L1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ALDH1L1, aldehyde dehydrogenase 1 family member L1
    Orthology source: HomoloGene
  • Synonyms
    10-fTHF, 10-FTHFDH, FDH, FTHFD
  • Links
    NCBI Gene ID: 10840
    neXtProt AC: NX_O75891

  • Chr Location
    3q21.3; chr3:126103561-126181526 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    4
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Aldh1l1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025984 VEGA Gene Model | MGI Sequence Detail 113777 C57BL/6J ±  kb
transcript OTTMUST00000064097 VEGA | MGI Sequence Detail 3052 Not Applicable  
polypeptide OTTMUSP00000031788 VEGA | MGI Sequence Detail 902 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    605 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000003924 10-formyltetrahydrofolate dehydrogenase
  • EC
  • InterPro Domains
    IPR011407 10-formyltetrahydrofolate dehydrogenase
    IPR016163 Aldehyde dehydrogenase, C-terminal
    IPR016160 Aldehyde dehydrogenase, cysteine active site
    IPR015590 Aldehyde dehydrogenase domain
    IPR029510 Aldehyde dehydrogenase, glutamic acid active site
    IPR016162 Aldehyde dehydrogenase N-terminal domain
    IPR016161 Aldehyde/histidinol dehydrogenase
    IPR005793 Formyl transferase, C-terminal
    IPR011034 Formyl transferase, C-terminal-like
    IPR002376 Formyl transferase, N-terminal
    IPR009081 Phosphopantetheine binding ACP domain
    IPR001555 Phosphoribosylglycinamide formyltransferase, active site
Molecular
Reagents
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  • All nucleic 150
    cDNA 149
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1917624
References
more
  • Summaries
    All 49
    Developmental Gene Expression 16
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228503 Altieri SC, et al., En1 directs superior olivary complex neuron positioning, survival, and expression of FoxP1. Dev Biol. 2015 Dec 1;408(1):99-108

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory