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Krt27 Gene Detail
Summary
  • Symbol
    Krt27
  • Name
    keratin 27
  • Synonyms
    Krt1-c29, mIRSa3.1, stpm
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339999
    NCBI Gene: 16675
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:99345565-99351104 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 62.92 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339999
protein coding gene Chr11:99345565-99351118 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019089
protein coding gene Chr11:102006078-102013131 (-)
A/J MGP_AJ_G0019057
protein coding gene Chr11:97712494-97718027 (-)
AKR/J MGP_AKRJ_G0019027
protein coding gene Chr11:100744684-100752633 (-)
BALB/cJ MGP_BALBcJ_G0019031
protein coding gene Chr11:98215641-98221189 (-)
C3H/HeJ MGP_C3HHeJ_G0018844
protein coding gene Chr11:100897078-100902604 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019482
protein coding gene Chr11:105141168-105149080 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017114
protein coding gene Chr11:95275216-95280792 (-)
CAST/EiJ MGP_CASTEiJ_G0018399
protein coding gene Chr11:101889095-101894645 (-)
CBA/J MGP_CBAJ_G0018815
protein coding gene Chr11:109526845-109532395 (-)
DBA/2J MGP_DBA2J_G0018923
protein coding gene Chr11:97274739-97280267 (-)
FVB/NJ MGP_FVBNJ_G0018912
protein coding gene Chr11:96790467-96795984 (-)
LP/J MGP_LPJ_G0018993
protein coding gene Chr11:102472821-102478345 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018939
protein coding gene Chr11:109194461-109199997 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019522
protein coding gene Chr11:101102594-101108145 (-)
PWK/PhJ MGP_PWKPhJ_G0018170
protein coding gene Chr11:98352012-98357550 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017958
protein coding gene Chr11:100860007-100865530 (-)
WSB/EiJ MGP_WSBEiJ_G0018447
protein coding gene Chr11:101076569-101083832 (-)



Homology
more
  • Human Ortholog
    KRT27, keratin 27
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KRT27, keratin 27
    Orthology source: HomoloGene, HGNC
  • Synonyms
    K25IRS3, KRT25C
  • Links
    NCBI Gene ID: 342574
    neXtProt AC: NX_Q7Z3Y8
    UniProt: Q7Z3Y8

  • Chr Location
    17q21.2; chr17:40776808-40782534 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Newborn heterozygotes show a slight bending of the whiskers. At ~P12, the coat develops a loose wave pattern. Whiskers of homozygotes are more curly and irregular while coat waviness occurs earlier and is more prominent. Adult coats are not waved but remains rough in texture.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017588 Ensembl Gene Model | MGI Sequence Detail 5540 C57BL/6J ±  kb
    transcript ENSMUST00000017732 Ensembl | MGI Sequence Detail 1550 Not Applicable  
    polypeptide ENSMUSP00000017732 Ensembl | MGI Sequence Detail 448 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 1
      cDNA 60
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:3521999
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 16
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:230728 Kumar V, et al., A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. J Cell Biol. 2015 Dec 7;211(5):1057-75

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    05/14/2019
    MGI 6.14
    The Jackson Laboratory