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Ilf3 Gene Detail
Summary
  • Symbol
    Ilf3
  • Name
    interleukin enhancer binding factor 3
  • Synonyms
    NF90
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339973
    NCBI Gene: 16201
  • Gene Overview
    MyGene.info: ILF3
Location & Maps
more
  • Sequence Map
    Chr9:21368019-21405361 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37343 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.78 cM, cytoband A4-A5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ILF3, interleukin enhancer binding factor 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ILF3, interleukin enhancer binding factor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CBTF, DRBF, DRBP76, MMP4, MPHOSPH4, MPP4, NF110, NF110b, NF90, NF90a, NF90b, NFAR, NFAR-1, NFAR2, NF-AT-90, TCP110, TCP80
  • Links
    NCBI Gene ID: 3609
    neXtProt AC: NX_Q12906

  • Chr Location
    19p13.2; chr19:10654261-10692419 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are born small and weak, show tachypnea and multi-organ apoptosis, and die neonatally due to neuromuscular respiratory failure. The diaphragm and other skeletal muscles show disorganization and paucity of myofibers,myocyte degeneration and elevated apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032178 Ensembl Gene Model | MGI Sequence Detail 37343 C57BL/6J ±  kb
transcript ENSMUST00000067646 Ensembl | MGI Sequence Detail 3402 Not Applicable  
polypeptide ENSMUSP00000065770 Ensembl | MGI Sequence Detail 898 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    64 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 213
    cDNA 211
    Primer pair 2

    Microarray probesets 7
References
more
  • Summaries
    All 41
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:54438 Buaas FW, et al., Cloning and characterization of the mouse interleukin enhancer binding factor 3 (Ilf3) homolog in a screen for RNA binding proteins. Mamm Genome. 1999 May;10(5):451-6
  • Latest
    J:210225 Wen X, et al., NF90 exerts antiviral activity through regulation of PKR phosphorylation and stress granules in infected cells. J Immunol. 2014 Apr 15;192(8):3753-64

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory