About   Help   FAQ
Rtn3 Gene Detail
Summary
  • Symbol
    Rtn3
  • Name
    reticulon 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339970
    NCBI Gene: 20168
  • Gene Overview
    MyGene.info: RTN3
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr19:7425901-7483289 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      57389 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.32 cM, cytoband A
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    RTN3, reticulon 3
  • Vertebrate Orthologs
    5
  • Human Ortholog
    RTN3, reticulon 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASYIP, HAP, NSPL2, NSPLII, RTN3-A1
  • Links
    NCBI Gene ID: 10313
    neXtProt AC: NX_O95197
    UniProt: O95197

  • Chr Location
    11q13.1; chr11:63681315-63759891 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from multigenic genotypes
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    220
  • Tissues
    97
  • cDNA Data
    22
  • Literature Summary
    6
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024758 Ensembl Gene Model | MGI Sequence Detail 57389 C57BL/6J ±  kb
transcript ENSMUST00000065304 Ensembl | MGI Sequence Detail 5030 Not Applicable  
polypeptide ENSMUSP00000065810 Ensembl | MGI Sequence Detail 964 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    208 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 22
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2147752
References
more
  • Summaries
    All 43
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:55487 Moreira EF, et al., Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13. Genomics. 1999 May 15;58(1):73-81
  • Latest
    J:240007 Sharoar MG, et al., Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease. Mol Psychiatry. 2016 Sep;21(9):1263-71
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory