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Rtn3 Gene Detail
Summary
  • Symbol
    Rtn3
  • Name
    reticulon 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339970
    NCBI Gene: 20168
  • Gene Overview
    MyGene.info: RTN3
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:7425901-7483281 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.32 cM, cytoband A
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    208 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339970
 protein coding gene Chr19:7425895-7483291 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024792
 protein coding gene Chr19:4562534-4622684 (-)
A/J MGP_AJ_G0024759
 protein coding gene Chr19:4200765-4261479 (-)
AKR/J MGP_AKRJ_G0024732
 protein coding gene Chr19:4335832-4395728 (-)
BALB/cJ MGP_BALBcJ_G0024759
 protein coding gene Chr19:4315715-4375267 (-)
C3H/HeJ MGP_C3HHeJ_G0024526
 protein coding gene Chr19:4470724-4530729 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025205
 protein coding gene Chr19:4650906-4722772 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022639
 protein coding gene Chr19:4109089-4171398 (-)
CAST/EiJ MGP_CASTEiJ_G0023999
 protein coding gene Chr19:4377141-4444128 (-)
CBA/J MGP_CBAJ_G0024499
 protein coding gene Chr19:4726517-4783533 (-)
DBA/2J MGP_DBA2J_G0024626
 protein coding gene Chr19:4167249-4224753 (-)
FVB/NJ MGP_FVBNJ_G0024591
 protein coding gene Chr19:4209553-4268396 (-)
LP/J MGP_LPJ_G0024712
 protein coding gene Chr19:4410150-4475372 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024621
 protein coding gene Chr19:4625176-4688571 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025253
 protein coding gene Chr19:4491511-4563350 (-)
PWK/PhJ MGP_PWKPhJ_G0023745
 protein coding gene Chr19:4229268-4291017 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023549
 protein coding gene Chr19:4300827-4363403 (-)
WSB/EiJ MGP_WSBEiJ_G0024061
 protein coding gene Chr19:4396430-4458579 (-)



Homology
more
  • Human Ortholog
    RTN3, reticulon 3
  • Vertebrate Orthologs
    5
  • Human Ortholog
    RTN3, reticulon 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASYIP, HAP, NSPL2, NSPLII, RTN3-A1
  • Links
    NCBI Gene ID: 10313
    neXtProt AC: NX_O95197
    UniProt: O95197

  • Chr Location
    11q13.1; chr11:63681315-63759891 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from multigenic genotypes
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    851
  • Tissues
    97
  • cDNA Data
    24
  • Literature Summary
    6
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024758 Ensembl Gene Model | MGI Sequence Detail 57381 C57BL/6J ±  kb
transcript ENSMUST00000065304 Ensembl | MGI Sequence Detail 5013 Not Applicable  
polypeptide ENSMUSP00000065810 Ensembl | MGI Sequence Detail 964 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 24
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2147752
References
more
  • Summaries
    All 47
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:55487 Moreira EF, et al., Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13. Genomics. 1999 May 15;58(1):73-81
  • Latest
    J:288812 Wang T, et al., BAP31 deficiency contributes to the formation of amyloid-beta plaques in Alzheimer's disease by reducing the stability of RTN3. FASEB J. 2019 Apr;33(4):4936-4946
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
02/23/2021
MGI 6.16 		The Jackson Laboratory