St3gal5
Gene Detail

Symbol Name ID

St3gal5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 MGI:1339963

Synonyms

3S-T, [a]2, GM3-specific sialytransferase, GM3 synthase, mST3Gal V, Siat9, ST3Gal V

Feature Type

protein coding gene

Genetic Map

Chromosome 6

32.24 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:72097613-72154570 bp, + strand From NCBI annotation of GRCm38   56958 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2893  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: sialyltransferase
Gene Tree: St3gal5

Human homologs

Human Homolog		ST3GAL5, ST3 beta-galactoside alpha-2,3-sialyltransferase 5
NCBI Gene ID		8869
neXtProt AC		NX_Q9UNP4
Human Synonyms		SATI, SIAT9, SIATGM3S, ST3GalV
Human Chr (Location)		2p11.2; chr2:86066271-86116157 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ST3GAL5

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous null mice are unable to synthesize GM3 ganglioside resulting in an enhanced sensitivity to insulin.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	protein glycosylation
Component	Golgi apparatus, integral to Golgi membrane, ...
Function	lactosylceramide alpha-2,3-sialyltransferase activity, sialyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (114)    Tissues (111)    Images (2)
Theiler Stages: 12, 20, 22, 24, 26, 28

Assay Type	Results
RNA in situ	94
RT-PCR	20

cDNA source data(45)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(48) cDNA(45) Primer pair(3)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000056091 (Evidence)
Entrez Gene	20454 (Evidence)
UniGene	38248
DFCI	TC1578737, TC1646807
DoTS	DT.87069493, DT.94334151, DT.97363349
NIA Mouse Gene Index	U007029, U233650
EC	2.4.99.9
Consensus CDS Project	CCDS20237.1, CCDS39510.1
International Mouse Knockout Project Status	St3gal5

Sequences

Length	Strain/Species
genomic	20454	NCBI Gene Model | MGI Sequence Detail	56958	C57BL/6J
transcript	NM_011375	RefSeq | MGI Sequence Detail	2448	C57BL/6
polypeptide	O88829	UniProt | EBI | MGI Sequence Detail	414	Not Applicable

All sequences(37) RefSeq(4) UniProt(1)

Polymorphisms

PCR(1) : SNPs(255 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001675	Glycosyl transferase, family 29
InterPro	IPR012163	Sialyltransferase
Protein Ontology	PR:000015682	lactosylceramide alpha-2,3-sialyltransferase

Graphical View of Protein Domain Structure

References

(Earliest) J:55319 Kono M, et al., Molecular cloning and functional expression of a fifth-type alpha 2,3-sialyltransferase (mST3Gal V: GM3 synthase). Biochem Biophys Res Commun. 1998 Dec 9;253(1):170-5
(Latest) J:193325 Boj SF, et al., Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607
All references(53)