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St3gal5
Gene Detail
 Symbol
Name
ID
St3gal5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
MGI:1339963
Synonyms 3S-T, [a]2, GM3-specific sialytransferase, GM3 synthase, mST3Gal V, Siat9, ST3Gal V
Feature Type protein coding gene
Genetic Map
Chromosome 6
32.24 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:72097613-72154570 bp, + strand
From NCBI annotation of GRCm38

  56958 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2893  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: sialyltransferase
Gene Tree: St3gal5

Human
homologs
Human Homolog ST3GAL5, ST3 beta-galactoside alpha-2,3-sialyltransferase 5
NCBI Gene ID 8869
neXtProt AC  NX_Q9UNP4
Human Synonyms  SATI, SIAT9, SIATGM3S, ST3GalV
Human Chr (Location)  2p11.2; chr2:85839147-85889034 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ST3GAL5
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are unable to synthesize GM3 ganglioside resulting in an enhanced sensitivity to insulin.
 
Interactions
St3gal5 interacts with 141 markers (Mir7-1, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process protein glycosylation, sialylation
Component Golgi apparatus, integral component of Golgi membrane, ...
Function lactosylceramide alpha-2,3-sialyltransferase activity, sialyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (114)    Tissues (111)    Images (2)
Theiler Stages: 12, 20, 22, 24, 26, 28
Assay TypeResults
RNA in situ 94
RT-PCR 20
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(45) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000056091 (Evidence)
Entrez Gene20454 (Evidence)
UniGene38248
DFCITC1578737, TC1646807
DoTSDT.87069493, DT.94334151, DT.97363349
NIA Mouse Gene IndexU007029, U233650
EC2.4.99.9
Consensus CDS ProjectCCDS20237.1, CCDS39510.1
International Mouse Knockout Project StatusSt3gal5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20454 NCBI Gene Model | MGI Sequence Detail 56958 C57BL/6J ±  kb
transcript NM_011375 RefSeq | MGI Sequence Detail 2453 C57BL/6 
polypeptide O88829 UniProt | EBI | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(16) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(310 from dbSNP Build 137)    SNPs within 2kb including multiple locations(318)
Protein-related
information
ResourceIDDescription
InterPro IPR001675 Glycosyl transferase, family 29
InterPro IPR012163 Sialyltransferase
Protein Ontology PR:000015682 lactosylceramide alpha-2,3-sialyltransferase
Graphical View of Protein Domain Structure
References (Earliest) J:55319 Kono M, et al., Molecular cloning and functional expression of a fifth-type alpha 2,3-sialyltransferase (mST3Gal V: GM3 synthase). Biochem Biophys Res Commun. 1998 Dec 9;253(1):170-5
(Latest) J:208060 Wang XQ, et al., Ganglioside GM3 Depletion Reverses Impaired Wound Healing in Diabetic Mice by Activating IGF-1 and Insulin Receptors. J Invest Dermatol. 2014 May;134(5):1446-55
All references(55)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory