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St3gal5
Gene Detail
Symbol

Name
ID
St3gal5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
MGI:1339963
Synonyms
3S-T, [a]2, GM3-specific sialytransferase, GM3 synthase, mST3Gal V, Siat9, ST3Gal V
Feature Type
protein coding gene
Genetic Map
Chromosome 6
32.24 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:72097592-72154571 bp, + strand
From VEGA annotation of GRCm38

  56980 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2893  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ST3GAL5
Protein SuperFamily: sialyltransferase
Gene Tree: St3gal5

Human
homologs
ST3GAL5, ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8869
neXtProt AC: NX_Q9UNP4

Human Synonyms: SATI, SIAT9, SIATGM3S, ST3GalV

Human Chr (Location): 2p11.2; chr2:85839147-85889034 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ST3GAL5

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(1) Targeted(3)
Genomic Mutations involving St3gal5 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are unable to synthesize GM3 ganglioside resulting in an enhanced sensitivity to insulin.
 
Interactions
St3gal5 interacts with 140 markers (Mir7-1, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (114)    Tissues (112)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 20
cDNA source data(45)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN st3gal5    NEW 
Molecular
reagents
All nucleic(48) cDNA(45) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000048445 (Evidence)
Ensembl Gene Model ENSMUSG00000056091 (Evidence)
Entrez Gene 20454 (Evidence)
UniGene 38248
DFCI TC1578737, TC1646807
DoTS DT.87069493, DT.94334151, DT.97363349
NIA Mouse Gene Index U007029, U233650
EC 2.4.99.9
Consensus CDS Project CCDS20237.1, CCDS39510.1
International Mouse Phenotyping Consortium Status St3gal5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048445 VEGA Gene Model | MGI Sequence Detail 56980 C57BL/6J ±  kb
transcript OTTMUST00000124165 VEGA | MGI Sequence Detail 2258 Not Applicable 
polypeptide OTTMUSP00000067606 VEGA | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(18) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(310 from dbSNP Build 137)    SNPs within 2kb including multiple locations(318)
Protein-related
information
ResourceIDDescription
InterPro IPR001675 Glycosyl transferase, family 29
Protein Ontology PR:000015682 lactosylceramide alpha-2,3-sialyltransferase
References
(Earliest) J:55319 Kono M, et al., Molecular cloning and functional expression of a fifth-type alpha 2,3-sialyltransferase (mST3Gal V: GM3 synthase). Biochem Biophys Res Commun. 1998 Dec 9;253(1):170-5
(Latest) J:221328 Randeria PS, et al., siRNA-based spherical nucleic acids reverse impaired wound healing in diabetic mice by ganglioside GM3 synthase knockdown. Proc Natl Acad Sci U S A. 2015 May 5;112(18):5573-8
All references(57)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory