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Ftcd Gene Detail
Summary
  • Symbol
    Ftcd
  • Name
    formiminotransferase cyclodeaminase
  • Synonyms
    glutamate formiminotransferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339962
    NCBI Gene: 14317
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:76575648-76590338 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.25 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339962
protein coding gene Chr10:76575648-76590340 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017387
protein coding gene Chr10:76829175-76845363 (+)
A/J MGP_AJ_G0017364
protein coding gene Chr10:74169745-74184260 (+)
AKR/J MGP_AKRJ_G0017325
protein coding gene Chr10:76168470-76184394 (+)
BALB/cJ MGP_BALBcJ_G0017324
protein coding gene Chr10:74372895-74388807 (+)
C3H/HeJ MGP_C3HHeJ_G0017148
protein coding gene Chr10:76247130-76264267 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017782
protein coding gene Chr10:79531805-79548775 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015472
protein coding gene Chr10:70614267-70628998 (+)
CAST/EiJ MGP_CASTEiJ_G0016718
protein coding gene Chr10:76566125-76582060 (+)
CBA/J MGP_CBAJ_G0017120
protein coding gene Chr10:82647766-82666222 (+)
DBA/2J MGP_DBA2J_G0017225
protein coding gene Chr10:73471283-73486392 (+)
FVB/NJ MGP_FVBNJ_G0017217
protein coding gene Chr10:72629371-72645443 (+)
LP/J MGP_LPJ_G0017298
protein coding gene Chr10:77309689-77328430 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017246
protein coding gene Chr10:84700263-84719145 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017821
protein coding gene Chr10:76230321-76245970 (+)
PWK/PhJ MGP_PWKPhJ_G0016502
protein coding gene Chr10:73319173-73334531 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016285
protein coding gene Chr10:75454682-75469085 (+)
WSB/EiJ MGP_WSBEiJ_G0016781
protein coding gene Chr10:76205399-76221041 (+)



Homology
more
  • Human Ortholog
    FTCD, formimidoyltransferase cyclodeaminase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FTCD, formimidoyltransferase cyclodeaminase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LCHC1
  • Links
    NCBI Gene ID: 10841
    neXtProt AC: NX_O95954
    UniProt: O95954

  • Chr Location
    21q22.3; chr21:46135981-46156481 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4848
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: FTCD
  • Gene Tree
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001155 Ensembl Gene Model | MGI Sequence Detail 14691 C57BL/6J ±  kb
transcript ENSMUST00000001183 Ensembl | MGI Sequence Detail 1933 Not Applicable  
polypeptide ENSMUSP00000001183 Ensembl | MGI Sequence Detail 541 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007689 formimidoyltransferase-cyclodeaminase
  • EC
  • InterPro Domains
    IPR007044 Cyclodeaminase/cyclohydrolase
    IPR036178 Formimidoyltransferase-cyclodeaminase-like superfamily
    IPR004227 Formiminotransferase catalytic domain
    IPR022384 Formiminotransferase catalytic domain superfamily
    IPR013802 Formiminotransferase, C-terminal subdomain
    IPR037070 Formiminotransferase, C-terminal subdomain superfamily
    IPR012886 Formiminotransferase, N-terminal subdomain
    IPR037064 Formiminotransferase, N-terminal subdomain superfamily
Molecular
Reagents
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  • All nucleic 45
    Genomic 1
    cDNA 41
    Primer pair 3

    Microarray probesets 3
References
more
  • Summaries
    All 59
    Developmental Gene Expression 8
    Diseases 2
    Gene Ontology 6
    Phenotypes 23
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory