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Nfe2l3 Gene Detail
Summary
  • Symbol
    Nfe2l3
  • Name
    nuclear factor, erythroid derived 2, like 3
  • Synonyms
    Nrf3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339958
    NCBI Gene: 18025
  • Gene Overview
    MyGene.info: NFE2L3
Location & Maps
more
  • Sequence Map
    Chr6:51432670-51458768 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26099 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NFE2L3, nuclear factor, erythroid 2 like 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NFE2L3, nuclear factor, erythroid 2 like 3
    Orthology source: HomoloGene
  • Synonyms
    NRF3
  • Links
    NCBI Gene ID: 9603
    neXtProt AC: NX_Q9Y4A8

  • Chr Location
    7p15.2; chr7:26152227-26187137 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    5 phenotype references
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034271 VEGA Gene Model | MGI Sequence Detail 26099 C57BL/6J ±  kb
transcript OTTMUST00000087085 VEGA | MGI Sequence Detail 2544 Not Applicable  
polypeptide OTTMUSP00000047221 VEGA | MGI Sequence Detail 660 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    57 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000011171 nuclear factor erythroid 2-related factor 3
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR004826 Basic leucine zipper domain, Maf-type
    IPR029854 Nuclear factor erythroid 2-related factor 3
    IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
Molecular
Reagents
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  • All nucleic 41
    cDNA 39
    Primer pair 1
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:53336 Kobayashi A, et al., Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. J Biol Chem. 1999 Mar 5;274(10):6443-52
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory