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Nfe2l3 Gene Detail
Summary
  • Symbol
    Nfe2l3
  • Name
    nuclear factor, erythroid derived 2, like 3
  • Synonyms
    Nrf3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339958
    NCBI Gene: 18025
  • Gene Overview
    MyGene.info: NFE2L3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:51432670-51458768 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 24.84 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339958
protein coding gene Chr6:51432670-51458768 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030733
protein coding gene Chr6:50617686-50647406 (+)
A/J MGP_AJ_G0030703
protein coding gene Chr6:48249373-48281343 (+)
AKR/J MGP_AKRJ_G0030629
protein coding gene Chr6:49937057-49965729 (+)
BALB/cJ MGP_BALBcJ_G0030714
protein coding gene Chr6:48610840-48637044 (+)
C3H/HeJ MGP_C3HHeJ_G0030428
protein coding gene Chr6:49953037-49983253 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031169
protein coding gene Chr6:51738150-51769270 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028376
protein coding gene Chr6:45927687-45953205 (+)
CAST/EiJ MGP_CASTEiJ_G0029830
protein coding gene Chr6:49722163-49751330 (+)
CBA/J MGP_CBAJ_G0030401
protein coding gene Chr6:53910746-53939088 (+)
DBA/2J MGP_DBA2J_G0030551
protein coding gene Chr6:48179327-48206012 (+)
FVB/NJ MGP_FVBNJ_G0030503
protein coding gene Chr6:47797698-47825022 (+)
LP/J MGP_LPJ_G0030636
protein coding gene Chr6:50587283-50616117 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030537
protein coding gene Chr6:56568167-56597258 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031199
protein coding gene Chr6:49855003-49884598 (+)
PWK/PhJ MGP_PWKPhJ_G0029543
protein coding gene Chr6:47780819-47807988 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029378
protein coding gene Chr6:49191670-49224507 (+)
WSB/EiJ MGP_WSBEiJ_G0029907
protein coding gene Chr6:49843714-49871609 (+)



Homology
more
  • Human Ortholog
    NFE2L3, nuclear factor, erythroid 2 like 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NFE2L3, nuclear factor, erythroid 2 like 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NRF3
  • Links
    NCBI Gene ID: 9603
    neXtProt AC: NX_Q9Y4A8
    UniProt: Q9Y4A8

  • Chr Location
    7p15.2; chr7:26152227-26187137 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    5 phenotype references
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18025 NCBI Gene Model | MGI Sequence Detail 26099 C57BL/6J ±  kb
transcript NM_010903 RefSeq | MGI Sequence Detail 2549 C57BL/6  
polypeptide Q9WTM4 UniProt | EBI | MGI Sequence Detail 660 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000011171 nuclear factor erythroid 2-related factor 3
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR004826 Basic leucine zipper domain, Maf-type
    IPR029854 Nuclear factor erythroid 2-related factor 3
    IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily
Molecular
Reagents
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  • All nucleic 43
    cDNA 41
    Primer pair 1
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 39
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:53336 Kobayashi A, et al., Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. J Biol Chem. 1999 Mar 5;274(10):6443-52
  • Latest
    J:239715 Galazo MJ, et al., Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity. Neuron. 2016 Jul 06;91(1):90-106

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory