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Nfe2l3
Gene Detail
 Symbol
Name
ID
Nfe2l3
nuclear factor, erythroid derived 2, like 3
MGI:1339958
Synonyms Nrf3
Feature Type protein coding gene
Genetic Map
Chromosome 6
24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:51432670-51458768 bp, + strand
From VEGA annotation of GRCm38

  26099 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3168  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: transcription factor TFC11
Gene Tree: Nfe2l3

Human
homologs
Human Homolog NFE2L3, nuclear factor, erythroid 2-like 3
NCBI Gene ID 9603
neXtProt AC  NX_Q9Y4A8
Human Synonyms  NRF3
Human Chr (Location)  7p15.2; chr7:26152227-26187137 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display a normal phenotype.
 
Interactions
Nfe2l3 interacts with 70 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process negative regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-templated, ...
Component nucleus
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (55)    Tissues (20)    Images (23)
Theiler Stages: 23, 24
Assay TypeResults
RNA in situ 50
RT-PCR 5
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(39) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000034271 (Evidence)
Ensembl Gene ModelENSMUSG00000029832 (Evidence)
Entrez Gene18025 (Evidence)
UniGene42138
DFCITC1580069, TC1594546
DoTSDT.110474308, DT.40146655, DT.50316706, DT.97397885
NIA Mouse Gene IndexU006856
Consensus CDS ProjectCCDS20134.1
International Mouse Knockout Project StatusNfe2l3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034271 VEGA Gene Model | MGI Sequence Detail 26099 C57BL/6J ±  kb
transcript OTTMUST00000087085 VEGA | MGI Sequence Detail 2544 Not Applicable 
polypeptide OTTMUSP00000047221 VEGA | MGI Sequence Detail 660 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(8)
Polymorphisms SNPs within 2kb(58 from dbSNP Build 137)    SNPs within 2kb including multiple locations(62)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
Protein Ontology PR:000011171 nuclear factor erythroid 2-related factor 3
References (Earliest) J:53336 Kobayashi A, et al., Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. J Biol Chem. 1999 Mar 5;274(10):6443-52
(Latest) J:169572 Chevillard G, et al., Nfe2l3 (Nrf3) deficiency predisposes mice to T-cell lymphoblastic lymphoma. Blood. 2011 Feb 10;117(6):2005-8
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory