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Adamts4 Gene Detail
Summary
  • Symbol
    Adamts4
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
  • Synonyms
    ADAM-TS4, aggrecanase-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339949
    NCBI Gene: 240913
  • Gene Overview
    MyGene.info: ADAMTS4
Location & Maps
more
  • Sequence Map
    Chr1:171250421-171260637 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10217 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ADAMTS4, ADAM metallopeptidase with thrombospondin type 1 motif 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ADAMTS4, ADAM metallopeptidase with thrombospondin type 1 motif 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADAMTS-2, ADAMTS-4, ADMP-1
  • Links
    NCBI Gene ID: 9507
    neXtProt AC: NX_O75173

  • Chr Location
    1q21-q23; chr1:161189748-161199055 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 6 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    2 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    2
  • Gene trapped
    10
  • Targeted
    11
  • Genomic Mutations
    2 involving Adamts4
  • Incidental Mutations
Homozygous mutant mice do not exhibit any morphological abnormalities. However, they do display impaired coordination and an increased susceptibility to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021528 VEGA Gene Model | MGI Sequence Detail 10217 C57BL/6J ±  kb
transcript OTTMUST00000051062 VEGA | MGI Sequence Detail 4389 Not Applicable  
polypeptide OTTMUSP00000023975 VEGA | MGI Sequence Detail 845 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    137 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 43
    cDNA 39
    Primer pair 4

    Microarray probesets 3
References
more
  • Summaries
    All 54
    Developmental Gene Expression 14
    Gene Ontology 7
    Phenotypes 20
  • Earliest
    J:55481 Tortorella MD, et al., Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins [see comments]. Science. 1999 Jun 4;284(5420):1664-6
  • Latest
    J:224408 Dubail J, et al., Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics. Matrix Biol. 2015 May-Jul;44-46:24-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory