Adamts4
Gene Detail

Symbol Name ID

Adamts4 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 MGI:1339949

Synonyms

ADAM-TS4, aggrecanase-1

Feature Type

protein coding gene

Genetic Map

Chromosome 1

79.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:171250421-171260637 bp, + strand From VEGA annotation of GRCm38   10217 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Adamts4 ± 2 cM)

Gene Tree: Adamts4

Human ortholog

ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 NCBI Gene ID 9507
Human Synonyms: ADAMTS-2, ADAMTS-4, ADMP-1
Human Chr1:161159538-161168845 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(20) : Targeted(10) Gene trapped(10)
 

Homozygous mutant mice do not exhibit any morphological abnormalities. However, they do display impaired coordination and an increased susceptibility to pharmacologically induced seizures.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	proteolysis
Component	extracellular matrix, extracellular region, ...
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (130)    Tissues (85)    Images (45)
Theiler Stages: 11, 23, 25, 28

Assay Type	Results
RNA in situ	16
In situ reporter (knock in)	75
RT-PCR	39

cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(43) cDNA(41) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021528 (Evidence)
Ensembl Gene Model	ENSMUSG00000006403 (Evidence)
Entrez Gene	240913 (Evidence)
UniGene	485813
DFCI	TC1578134, TC1631971, TC1640871
DoTS	DT.40142777, DT.97339683
NIA Mouse Gene Index	U001081
EC	3.4.24.82
Consensus CDS Project	CCDS15485.1
International Mouse Knockout Project Status	Adamts4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021528	VEGA Gene Model | MGI Sequence Detail	10217	C57BL/6J
transcript	OTTMUST00000051062	VEGA | MGI Sequence Detail	4389	Not Applicable
polypeptide	OTTMUSP00000023975	VEGA | MGI Sequence Detail	833	Not Applicable

All sequences(44) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(64 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR010294	ADAM-TS Spacer 1
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR001590	Peptidase M12B, ADAM/reprolysin
InterPro	IPR013273	Peptidase M12B, ADAM-TS
InterPro	IPR002870	Peptidase M12B, propeptide
InterPro	IPR000884	Thrombospondin, type 1 repeat
Protein Ontology	PR:000003733	A disintegrin and metalloproteinase with thrombospondin motifs 4

References

(Earliest) J:55481 Tortorella MD, et al., Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins [see comments]. Science. 1999 Jun 4;284(5420):1664-6
(Latest) J:188497 Hisanaga A, et al., A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves Reelin in an isoform-dependent manner. FEBS Lett. 2012 Sep 21;586(19):3349-53
All references(53)