Tbpl1
Gene Detail

Symbol Name ID

Tbpl1 TATA box binding protein-like 1 MGI:1339946

Synonyms

TLF, Tlp, TRF2, TRP

Feature Type

protein coding gene

Genetic Map

Chromosome 10

10.25 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:22703879-22731938 bp, - strand From VEGA annotation of GRCm38   28060 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3577  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: TATA-box binding protein
Gene Tree: Tbpl1

Human homologs

Human Homolog		TBPL1, TBP-like 1
NCBI Gene ID		9519
neXtProt AC		NX_P62380
Human Synonyms		MGC:8389, MGC:9620, STUD, TLF, TLP, TRF2
Human Chr (Location)		6q22.1-q22.3; chr6:134273308-134308638 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(4) Gene trapped(3)
 

Males homozygous for targeted null mutations are sterile due to a block in spermiogenesis. Spermatids exhibit defective acrosome formation, fragmentation of the chromocenter, and develop at most to step 7 of differentiation.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	acrosome assembly, DNA-dependent transcription, initiation, ...
Component	cytoplasm, nucleus, ...
Function	DNA binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (156)    Tissues (81)    Images (32)
Theiler Stages: 1, 2, 3, 4, 5, 17, 21, 23, 28

Assay Type	Results
RNA in situ	112
RT-PCR	37
RNase protection	7

cDNA source data(78)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(82) cDNA(78) Primer pair(3) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000028051 (Evidence)
Ensembl Gene Model	ENSMUSG00000071359 (Evidence)
Entrez Gene	237336 (Evidence)
UniGene	86670
DFCI	TC1574285, TC1596186, TC1626329
NIA Mouse Gene Index	U031604
Consensus CDS Project	CCDS23730.1
International Mouse Knockout Project Status	Tbpl1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028051	VEGA Gene Model | MGI Sequence Detail	28060	C57BL/6J
transcript	OTTMUST00000069470	VEGA | MGI Sequence Detail	2873	Not Applicable
polypeptide	OTTMUSP00000035282	VEGA | MGI Sequence Detail	186	Not Applicable

All sequences(40) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(69 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012295	Beta2-adaptin/TBP, C-terminal domain
InterPro	IPR000814	TATA-box binding protein
Protein Ontology	PR:000016138	TATA box-binding protein-like protein 1

References

(Earliest) J:52876 Ohbayashi T, et al., Identification of a mouse TBP-like protein (TLP) distantly related to the drosophila TBP-related factor. Nucleic Acids Res. 1999 Feb 1;27(3):750-5
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(56)

Other accession IDs

MGI:2143790, MGI:2143841, MGI:2143952