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Tbpl1
Gene Detail
 Symbol
Name
ID
Tbpl1
TATA box binding protein-like 1
MGI:1339946
Synonyms TLF, Tlp, TRF2, TRP
Feature Type protein coding gene
Genetic Map
Chromosome 10
10.25 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:22703879-22731938 bp, - strand
From VEGA annotation of GRCm38

  28060 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3577  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: TATA-box binding protein
Gene Tree: Tbpl1

Human
homologs
Human Homolog TBPL1, TBP-like 1
NCBI Gene ID 9519
neXtProt AC  NX_P62380
Human Synonyms  MGC:8389, MGC:9620, STUD, TLF, TLP, TRF2
Human Chr (Location)  6q22.1-q22.3; chr6:133952170-133987500 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Males homozygous for targeted null mutations are sterile due to a block in spermiogenesis. Spermatids exhibit defective acrosome formation, fragmentation of the chromocenter, and develop at most to step 7 of differentiation.
 
Interactions
Tbpl1 interacts with 301 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process acrosome assembly, DNA-templated transcription, initiation, ...
Component cytoplasm, nucleus, ...
Function DNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (149)    Tissues (76)    Images (32)
Theiler Stages: 1, 2, 3, 4, 5, 17, 21, 23, 27, 28
Assay TypeResults
RNA in situ 112
RT-PCR 30
RNase protection 7
cDNA source data(79)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(83) cDNA(79) Primer pair(3) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000028051 (Evidence)
Ensembl Gene ModelENSMUSG00000071359 (Evidence)
Entrez Gene237336 (Evidence)
UniGene86670
DFCITC1574285, TC1596186, TC1626329
NIA Mouse Gene IndexU031604
Consensus CDS ProjectCCDS23730.1
International Mouse Knockout Project StatusTbpl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028051 VEGA Gene Model | MGI Sequence Detail 28060 C57BL/6J ±  kb
transcript OTTMUST00000069470 VEGA | MGI Sequence Detail 2873 Not Applicable 
polypeptide OTTMUSP00000035282 VEGA | MGI Sequence Detail 186 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012295 Beta2-adaptin/TBP, C-terminal domain
InterPro IPR000814 TATA-box binding protein
Protein Ontology PR:000016138 TATA box-binding protein-like protein 1
References (Earliest) J:52876 Ohbayashi T, et al., Identification of a mouse TBP-like protein (TLP) distantly related to the drosophila TBP-related factor. Nucleic Acids Res. 1999 Feb 1;27(3):750-5
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(56)
Other
accession IDs
MGI:2143790, MGI:2143841, MGI:2143952

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory