Cxcl15 MGI Mouse Gene Detail - MGI:1339941 - C-X-C motif chemokine ligand 15

Symbol

Cxcl15
Name

C-X-C motif chemokine ligand 15
Synonyms

Il8, lungkine, Scyb15, weche

Feature Type

protein coding gene
IDs

MGI:1339941
NCBI Gene: 20309
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr5:90942393-90950926 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 44.78 cM
Mapping Data

3 experiments

SNPs within 2kb

39 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1339941	protein coding gene	Chr5:90942393-90950926 (+)
129S1/SvImJ	ENSMUSG00200007746	protein coding gene	Chr5:86676417-86684932 (+)
A/J	ENSMUSG00195024489	protein coding gene	Chr5:85845159-85853676 (+)
AKR/J	ENSMUSG00220011984	protein coding gene	Chr5:85990801-85999321 (+)
BALB/cJ	ENSMUSG00180022024	protein coding gene	Chr5:85704759-85713271 (+)
C3H/HeJ	ENSMUSG00175037854	protein coding gene	Chr5:87800374-87808889 (+)
C57BL/6NJ	ENSMUSG00215023125	protein coding gene	Chr5:86538130-86546656 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027396	protein coding gene	Chr5:83963763-83975439 (+)
CAST/EiJ	ENSTCUG00005033533	protein coding gene	Chr5:85449557-85457913 (+)
CBA/J	ENSMUSG00210005597	protein coding gene	Chr5:86600153-86608665 (+)
DBA/2J	ENSMUSG00185039001	protein coding gene	Chr5:88521110-88529622 (+)
FVB/NJ	ENSMUSG00205024904	protein coding gene	Chr5:85420945-85429453 (+)
JF1/MsJ	ENSUMUG00000040740	protein coding gene	Chr5:92799790-92808437 (+)
LP/J	ENSMUSG00230024109	protein coding gene	Chr5:93202765-93211281 (+)
NOD/ShiLtJ	ENSMUSG00190030266	protein coding gene	Chr5:85482645-85491157 (+)
NZO/HlLtJ	ENSMUSG00225008523	protein coding gene	Chr5:98350284-98358794 (+)
PWK/PhJ	ENSLUMG00010025934	protein coding gene	Chr5:85469849-85478467 (+)
SPRET/EiJ	ENSMSPG00010034453	protein coding gene	Chr5:87871807-87879215 (+)
WSB/EiJ	ENSIUOG00005027594	protein coding gene	Chr5:88484413-88492936 (+)

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Gene Tree

Cxcl15

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

6
Radiation induced

1
Spontaneous

1
Targeted

2
Genomic Mutations

4 involving Cxcl15
Incidental Mutations

APF
Find Mice (IMSR)

18 strains or lines available

Mice homozygous for a targeted null mutation are viable and fertile but display reduced host defense against the pulmonary pathogen Klebsiella pneumoniae.

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All GO Annotations

19
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

688
Tissues

61
cDNA Data

12
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS19418.1

Ensembl

ENSMUSG00000029375 (Evidence)
NCBI Gene

20309

			Length	Strain/Species	Flank
genomic	20309	NCBI Gene Model \| MGI Sequence Detail	8534	C57BL/6J	± kb
transcript	NM_011339	RefSeq \| MGI Sequence Detail	2127	ZRU/MplStud
polypeptide	Q9WVL7	UniProt \| EBI \| MGI Sequence Detail	167	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006217 C-X-C motif chemokine 15

(term hierarchy)
InterPro Domains

IPR039809 Chemokine beta/gamma/delta

IPR001811 Chemokine interleukin-8-like domain

IPR036048 Chemokine interleukin-8-like superfamily

IPR001089 CXC chemokine

IPR018048 CXC chemokine, conserved site

IPR033899 CXC Chemokine domain

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All nucleic 17

cDNA 12

Primer pair 5

Antibodies 1

Microarray probesets 4

Summaries

All 55

Developmental Gene Expression 12

Gene Ontology 5

Phenotypes 11
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:369666 Guo J, et al., Single-cell transcriptome analysis reveals abnormal angiogenesis and placentation by loss of imprinted glutaminyl-peptide cyclotransferase. J Zhejiang Univ Sci B. 2025 Jun 15;26(6):589-608

TSS for Cxcl15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47208	Chr5:90942389-90942405 (+)	4 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29