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Csf2rb2 Gene Detail
Summary
  • Symbol
    Csf2rb2
  • Name
    colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
  • Synonyms
    AIC2A, BetaIl3, Bil3, Il3r, Il3rb2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339760
    NCBI Gene: 12984
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:78282507-78305721 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.22 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    272 from dbSNP Build 142
  • Strain Annotations
    6
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339760
protein coding gene Chr15:78282507-78305721 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0021999
protein coding gene Chr15:75716240-75742306 (-)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0019978
protein coding gene Chr15:72279547-72305435 (-)
CAST/EiJ MGP_CASTEiJ_G0021298
protein coding gene Chr15:78493462-78528943 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0021040
protein coding gene Chr15:75298532-75328749 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020877
protein coding gene Chr15:77725545-77743090 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CSF2RB, colony stimulating factor 2 receptor beta common subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CSF2RB, colony stimulating factor 2 receptor beta common subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    betaGMR, CD131, CDw131, IL3RB, IL5RB, SMDP5
  • Links
    NCBI Gene ID: 1439
    neXtProt AC: NX_P32927
    UniProt: P32927

  • Chr Location
    22q12.3; chr22:36913574-36940449 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CSF2RB associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation are apparently normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12984 NCBI Gene Model | MGI Sequence Detail 23215 C57BL/6J ±  kb
transcript NM_007781 RefSeq | MGI Sequence Detail 4740 C57BL/6  
polypeptide P26954 UniProt | EBI | MGI Sequence Detail 878 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000006203 interleukin-3 receptor class 2 beta chain
  • PDB
  • InterPro Domains
    IPR011365 Cytokine IL-3/IL-5/GM-CSF receptor common beta chain
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR013783 Immunoglobulin-like fold
    IPR015373 Interferon/interleukin receptor domain
    IPR003531 Short hematopoietin receptor, family 1, conserved site
    IPR015321 Type I cytokine receptor, cytokine-binding domain
Molecular
Reagents
less
  • All nucleic 63
    Genomic 3
    cDNA 57
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11380, MGD-MRK-11382, MGD-MRK-11384, MGD-MRK-2189, MGI:96555
References
more
  • Summaries
    All 76
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 3
    Phenotypes 35
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:258170 Kreslavsky T, et al., Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells. Nat Immunol. 2017 Apr;18(4):442-455

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory