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Csf2rb2 Gene Detail
Summary
  • Symbol
    Csf2rb2
  • Name
    colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
  • Synonyms
    AIC2A, BetaIl3, Bil3, Il3r, Il3rb2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339760
    NCBI Gene: 12984
Location & Maps
more
  • Sequence Map
    Chr15:78282517-78305603 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23087 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CSF2RB, colony stimulating factor 2 receptor beta common subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CSF2RB, colony stimulating factor 2 receptor beta common subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD131, CDw131, IL3RB, IL5RB, SMDP5
  • Links
    NCBI Gene ID: 1439
    neXtProt AC: NX_P32927

  • Chr Location
    22q13.1; chr22:36913575-36940449 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CSF2RB associations

Human Disease Mouse Models
       Surfactant Metabolism Dysfunction, Pulmonary, 5; SMDP5   OMIM: 614370
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Csf2rb2
  • Incidental Mutations
Homozygotes for a targeted null mutation are apparently normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071714 Ensembl Gene Model | MGI Sequence Detail 23087 C57BL/6J ±  kb
transcript ENSMUST00000096356 Ensembl | MGI Sequence Detail 4612 Not Applicable  
polypeptide ENSMUSP00000094083 Ensembl | MGI Sequence Detail 878 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    272 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000006203 interleukin-3 receptor class 2 beta chain
  • PDB
  • InterPro Domains
    IPR011365 Cytokine IL-3/IL-5/GM-CSF receptor common beta chain
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR015373 Interferon/interleukin receptor domain
    IPR003531 Short hematopoietin receptor, family 1, conserved site
    IPR015321 Type I cytokine receptor, cytokine-binding domain
Molecular
Reagents
less
  • All nucleic 62
    Genomic 3
    cDNA 56
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11380, MGD-MRK-11382, MGD-MRK-11384, MGD-MRK-2189, MGI:96555
References
more
  • Summaries
    All 50
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 3
    Phenotypes 32
  • Earliest
    J:2991 Itoh N, et al., Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family. Science. 1990 Jan 19;247(4940):324-7
  • Latest
    J:209599 Mortha A, et al., Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science. 2014 Mar 28;343(6178):1249288

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory