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Csf2rb Gene Detail
Summary
  • Symbol
    Csf2rb
  • Name
    colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
  • Synonyms
    AIC2B, Bc, beta c, CDw131, common beta chain, Csf2rb1, Il3r, Il3rb1, Il5rb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339759
    NCBI Gene: 12983
Location & Maps
more
  • Sequence Map
    Chr15:78325990-78351000 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25011 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.36 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CSF2RB, colony stimulating factor 2 receptor beta common subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CSF2RB, colony stimulating factor 2 receptor beta common subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD131, CDw131, IL3RB, IL5RB, SMDP5
  • Links
    NCBI Gene ID: 1439
    neXtProt AC: NX_P32927

  • Chr Location
    22q13.1; chr22:36913575-36940449 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Csf2rb mouse models; 1 with human CSF2RB associations

Human Disease Mouse Models
       Surfactant Metabolism Dysfunction, Pulmonary, 1; SMDP1   OMIM: 265120 View 2 models
       Surfactant Metabolism Dysfunction, Pulmonary, 5; SMDP5   OMIM: 614370
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    20 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    8
  • Genomic Mutations
    3 involving Csf2rb
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit lung pathology including lymphocytic infiltration, alveolar proteinosis-like areas, and increased saturated phosphatidylcholine pool sizes. Mutants also have low peripheral eosinophil numbers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071713 Ensembl Gene Model | MGI Sequence Detail 25011 C57BL/6J ±  kb
transcript ENSMUST00000096355 Ensembl | MGI Sequence Detail 4764 Not Applicable  
polypeptide ENSMUSP00000094082 Ensembl | MGI Sequence Detail 896 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    178 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    9 Sequences
  • InterPro Domains
    IPR011365 Cytokine IL-3/IL-5/GM-CSF receptor common beta chain
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR015373 Interferon/interleukin receptor domain
    IPR003531 Short hematopoietin receptor, family 1, conserved site
    IPR015321 Type I cytokine receptor, cytokine-binding domain
Molecular
Reagents
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  • All nucleic 57
    Genomic 3
    cDNA 49
    Primer pair 5

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-11380, MGD-MRK-11382, MGD-MRK-11383, MGD-MRK-11390, MGD-MRK-2189, MGI:2146084, MGI:96554
References
more
  • Summaries
    All 105
    Developmental Gene Expression 7
    Diseases 4
    Gene Ontology 4
    Phenotypes 73
  • Earliest
    J:10638 Gorman DM, et al., Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family. Proc Natl Acad Sci U S A. 1990 Jul;87(14):5459-63
  • Latest
    J:230585 Van Overmeire E, et al., M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment. Cancer Res. 2016 Jan 1;76(1):35-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory