Csf2rb
Gene Detail

Symbol Name ID

Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) MGI:1339759

Synonyms

AIC2B, Bc, beta c, CDw131, common beta chain, Csf2rb1, Il3r, Il3rb1, Il5rb

Feature Type

protein coding gene

Genetic Map

Chromosome 15

37.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr15:78325990-78351000 bp, + strand From Ensembl annotation of GRCm38   25011 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:339  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: cytokine IL-3/IL-5/GM-CSF receptor common beta chain
Gene Tree: Csf2rb

Human homologs

Human Homolog		CSF2RB, colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
NCBI Gene ID		1439
neXtProt AC		NX_P32927
Human Synonyms		CD131, CDw131, IL3RB, IL5RB, SMDP5
Human Chr (Location)		22q13.1; chr22:37309675-37336481 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CSF2RB

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homozygotes for targeted null mutations exhibit lung pathology including lymphocytic infiltration, alveolar proteinosis-like areas, and increased saturated phosphatidylcholine pool sizes. Mutants also have low peripheral eosinophil numbers.

 
Human Diseases Modeled Using Mouse Csf2rb (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	cytokine-mediated signaling pathway
Component	integral to membrane, membrane
Function	cytokine receptor activity, protein binding

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (19)    Tissues (17)    Images (1)
Theiler Stages: 1, 2, 3, 4, 5, 12, 13, 14, 26, 28

Assay Type	Results
Northern blot	3
RT-PCR	16

cDNA source data(46)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(57) Genomic(3) cDNA(49) Primer pair(5)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000071713 (Evidence)
Entrez Gene	12983 (Evidence)
UniGene	235324
DFCI	TC1573248, TC1664465
DoTS	DT.101345225, DT.101345646, DT.101387479, DT.101387480, DT.99859351, DT.99866533
NIA Mouse Gene Index	U016403
Consensus CDS Project	CCDS27612.1
International Mouse Knockout Project Status	Csf2rb

Sequences

Length	Strain/Species
genomic	ENSMUSG00000071713	Ensembl Gene Model | MGI Sequence Detail	25011	C57BL/6J
transcript	ENSMUST00000096355	Ensembl | MGI Sequence Detail	4764	Not Applicable
polypeptide	ENSMUSP00000094082	Ensembl | MGI Sequence Detail	896	Not Applicable

All sequences(59) RefSeq(2) UniProt(9)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(147 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011365	Cytokine IL-3/IL-5/GM-CSF receptor common beta chain
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR015373	Interferon alpha/beta receptor, beta chain
InterPro	IPR015321	Interleukin-6 receptor alpha chain, binding
InterPro	IPR003531	Short hematopoietin receptor, family 1, conserved site
Protein Ontology	PR:000001339	cytokine receptor common beta chain

References

(Earliest) J:10638 Gorman DM, et al., Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family. Proc Natl Acad Sci U S A. 1990 Jul;87(14):5459-63
(Latest) J:190604 Giacomin PR, et al., Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection. J Immunol. 2012 Nov 1;189(9):4371-8
All references(89)

Other accession IDs

MGD-MRK-11380, MGD-MRK-11382, MGD-MRK-11383, MGD-MRK-11390, MGD-MRK-2189, MGI:2146084, MGI:96554