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Csf2rb
Gene Detail
 Symbol
Name
ID
Csf2rb
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
MGI:1339759
Synonyms AIC2B, Bc, beta c, CDw131, common beta chain, Csf2rb1, Il3r, Il3rb1, Il5rb
Feature Type protein coding gene
Genetic Map
Chromosome 15
37.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:78325990-78351000 bp, + strand
From Ensembl annotation of GRCm38

  25011 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:339  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken

Protein SuperFamily: cytokine IL-3/IL-5/GM-CSF receptor common beta chain
Gene Tree: Csf2rb

Human
homologs
Human Homolog CSF2RB, colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
NCBI Gene ID 1439
neXtProt AC  NX_P32927
Human Synonyms  CD131, CDw131, IL3RB, IL5RB, SMDP5
Human Chr (Location)  22q13.1; chr22:36913597-36940449 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CSF2RB
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Radiation induced(1) Targeted(7)
Genomic Mutations involving Csf2rb (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit lung pathology including lymphocytic infiltration, alveolar proteinosis-like areas, and increased saturated phosphatidylcholine pool sizes. Mutants also have low peripheral eosinophil numbers.
 
Human Diseases Modeled Using Mouse Csf2rb (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Csf2rb interacts with 243 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cytokine-mediated signaling pathway
Component integral component of membrane, membrane
Function cytokine receptor activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (16)    Tissues (14)    Images (1)
Theiler Stages: 1, 2, 3, 4, 5, 12, 13, 14, 26, 28
Assay TypeResults
Northern blot 3
RT-PCR 13
cDNA source data(46)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(57) Genomic(3) cDNA(49) Primer pair(5)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000071713 (Evidence)
Entrez Gene12983 (Evidence)
UniGene235324
DoTSDT.101345225, DT.101345646, DT.101387479, DT.101387480, DT.99859351, DT.99866533
Consensus CDS ProjectCCDS27612.1
International Mouse Knockout Project StatusCsf2rb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071713 Ensembl Gene Model | MGI Sequence Detail 25011 C57BL/6J ±  kb
transcript ENSMUST00000096355 Ensembl | MGI Sequence Detail 4764 Not Applicable 
polypeptide ENSMUSP00000094082 Ensembl | MGI Sequence Detail 896 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(10) UniProt(9)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(220 from dbSNP Build 137)    SNPs within 2kb including multiple locations(304)
Protein-related
information
ResourceIDDescription
InterPro IPR011365 Cytokine IL-3/IL-5/GM-CSF receptor common beta chain
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015373 Interferon alpha/beta receptor, beta chain
InterPro IPR015321 Interleukin-6 receptor alpha chain, binding
InterPro IPR003531 Short hematopoietin receptor, family 1, conserved site
Protein Ontology PR:000001339 cytokine receptor common subunit beta
References (Earliest) J:10638 Gorman DM, et al., Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family. Proc Natl Acad Sci U S A. 1990 Jul;87(14):5459-63
(Latest) J:211681 Yao H, et al., Corepressor Rcor1 is essential for murine erythropoiesis. Blood. 2014 May 15;123(20):3175-84
All references(98)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11380, MGD-MRK-11382, MGD-MRK-11383, MGD-MRK-11390, MGD-MRK-2189, MGI:2146084, MGI:96554

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory