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Myh4 Gene Detail
Summary
  • Symbol
    Myh4
  • Name
    myosin, heavy polypeptide 4, skeletal muscle
  • Synonyms
    MHC2B, Minimsc, Minmus, MM, MYH-2B, MyHC-IIb, Myhsf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339713
    NCBI Gene: 17884
  • Gene Overview
    MyGene.info: MYH4
Location & Maps
more
  • Sequence Map
    Chr11:67238029-67260446 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22418 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MYH4, myosin, heavy chain 4, skeletal muscle
  • Vertebrate Orthologs
    20
  • Human Ortholog
    MYH4, myosin, heavy chain 4, skeletal muscle
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MYH2B, MyHC-2B, MyHC-IIb
  • Links
    NCBI Gene ID: 4622
    neXtProt AC: NX_Q9Y623

  • Chr Location
    17p13.1; chr17:10443290-10469559 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 123880
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;4 western clawed frog;9 zebrafish
  • HCOP
    human homology predictions: MYH4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • QTL
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Myh4
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit decreased growth and muscle defects including reduced muscle mass, muscle fiber loss, compensatory fiber hypertrophy, and impaired strength.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005921 VEGA Gene Model | MGI Sequence Detail 22418 C57BL/6J ±  kb
transcript OTTMUST00000013183 VEGA | MGI Sequence Detail 6016 Not Applicable  
polypeptide OTTMUSP00000006119 VEGA | MGI Sequence Detail 1939 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    339 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 31
    Genomic 9
    cDNA 14
    Primer pair 6
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1261431, MGI:2144213, MGI:4420408
References
more
  • Summaries
    All 78
    Developmental Gene Expression 30
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:7242 Weydert A, et al., Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle. J Biol Chem. 1983 Nov 25;258(22):13867-74
  • Latest
    J:228946 Wei N, et al., SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing. Cell Rep. 2015 Nov 24;13(8):1647-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory