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Myh4
Gene Detail
Symbol

Name
ID
Myh4
myosin, heavy polypeptide 4, skeletal muscle
MGI:1339713
Synonyms
MHC2B, Minimsc, Minmus, MM, MYH-2B, MyHC-IIb, Myhsf
Feature Type
protein coding gene
Genetic Map
Chromosome 11
40.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr11:67238029-67260446 bp, + strand
From VEGA annotation of GRCm38

  22418 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:123880  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 4 western clawed frog; 9 zebrafish

HCOP human homology predictions: MYH4
Gene Tree: Myh4

Human
homologs
MYH4, myosin, heavy chain 4, skeletal muscle
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4622
neXtProt AC: NX_Q9Y623

Human Synonyms: MYH2B, MyHC-2B, MyHC-IIb

Human Chr (Location): 17p13.1; chr17:10443290-10469559 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) QTL(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit decreased growth and muscle defects including reduced muscle mass, muscle fiber loss, compensatory fiber hypertrophy, and impaired strength.
 
Phenotype Images(1)
Interactions
Myh4 interacts with 91 markers (Mir17, Mir20b, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process muscle contraction, response to activity
Component cytoplasm, myofibril, ...
Function actin binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (208)    Tissues (38)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 168
RT-PCR 32
RNase protection 6
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MYH1C ; Xenbase myh4    NEW 
Molecular
reagents
All nucleic(31) Genomic(9) cDNA(14) Primer pair(6) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005921 (Evidence)
Ensembl Gene Model ENSMUSG00000057003 (Evidence)
Entrez Gene 17884 (Evidence)
DoTS DT.55214348, DT.87051250, DT.110541088, DT.110519834, DT.110519827, DT.103572666, DT.110519846, DT.110519913, DT.101358645, DT.97353527, DT.94349211, DT.94359223
Consensus CDS Project CCDS24856.1
International Mouse Phenotyping Consortium Status Myh4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005921 VEGA Gene Model | MGI Sequence Detail 22418 C57BL/6J ±  kb
transcript OTTMUST00000013183 VEGA | MGI Sequence Detail 6016 Not Applicable 
polypeptide OTTMUSP00000006119 VEGA | MGI Sequence Detail 1939 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(2) UniProt(9)
Polymorphisms
RFLP(6) : SNPs within 2kb(336 from dbSNP Build 137)    SNPs within 2kb including multiple locations(338)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027401 Myosin-like IQ motif-containing domain
InterPro IPR004009 Myosin, N-terminal, SH3-like
InterPro IPR008989 Myosin S1 fragment, N-terminal
InterPro IPR002928 Myosin tail
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010828 myosin-4
References
(Earliest) J:7242 Weydert A, et al., Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle. J Biol Chem. 1983 Nov 25;258(22):13867-74
(Latest) J:212185 Petchey LK, et al., Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9515-20
All references(77)
Other
accession IDs
MGI:1261431, MGI:2144213, MGI:4420408

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory