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Myh1 Gene Detail
Summary
  • Symbol
    Myh1
  • Name
    myosin, heavy polypeptide 1, skeletal muscle, adult
  • Synonyms
    A530084A17Rik, IId, IId/x, MyHC-IId/x, MYHC-IIX, Myhs-f, Myhsf2, Myhs-f2, myosin heavy chain 2X
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339711
    NCBI Gene: 17879
  • Gene Overview
    MyGene.info: MYH1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:67200052-67224575 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24524 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 40.59 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MYH1, myosin heavy chain 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    MYH1, myosin heavy chain 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL71, MYHa, MyHC-2x, MyHC-2X/D, MYHSA1
  • Links
    NCBI Gene ID: 4619
    neXtProt AC: NX_P12882
    UniProt: P12882

  • Chr Location
    17p13.1; chr17:10492307-10518719 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced growth, muscular weakness, kyphosis, and abnormal kinetics of muscle contraction and relaxation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005918 VEGA Gene Model | MGI Sequence Detail 24524 C57BL/6J ±  kb
    transcript OTTMUST00000013178 VEGA | MGI Sequence Detail 6081 Not Applicable  
    polypeptide OTTMUSP00000006115 VEGA | MGI Sequence Detail 1942 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      312 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 9
      cDNA 18
      Primer pair 8

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12755, MGD-MRK-12757, MGD-MRK-12761, MGI:2441807, MGI:97264
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 42
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:260151 Ito K, et al., Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters. Sci Rep. 2018 Jan 11;8(1):434

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory