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Myh1
Gene Detail
 Symbol
Name
ID
Myh1
myosin, heavy polypeptide 1, skeletal muscle, adult
MGI:1339711
Synonyms A530084A17Rik, IId, IId/x, MyHC-IId/x, MYHC-IIX, Myhs-f, Myhsf2, Myhs-f2, myosin heavy chain 2X
Feature Type protein coding gene
Genetic Map
Chromosome 11
40.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:67200052-67224575 bp, + strand
From VEGA annotation of GRCm38

  24524 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133718  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 6 western clawed frog

Gene Tree: Myh1

Human
homologs
Human Homolog MYH1, myosin, heavy chain 1, skeletal muscle, adult
NCBI Gene ID 4619
neXtProt AC  NX_P12882
Human Synonyms  HEL71, MYHa, MyHC-2x, MyHC-2X/D, MYHSA1
Human Chr (Location)  17p13.1; chr17:10492307-10518542 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit reduced growth, muscular weakness, kyphosis, and abnormal kinetics of muscle contraction and relaxation.
 
Phenotype Images(2)
Interactions
Myh1 interacts with 67 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process muscle contraction
Component A band, cytoplasm, ...
Function actin binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (63)    Tissues (58)    Images (3)
Theiler Stages: 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 1
RT-PCR 62
cDNA source data(15)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(34) Genomic(9) cDNA(18) Primer pair(7)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000005918 (Evidence)
Ensembl Gene ModelENSMUSG00000056328 (Evidence)
Entrez Gene17879 (Evidence)
UniGene477065
DoTSDT.110519816, DT.94307710
NIA Mouse Gene IndexU123650
Consensus CDS ProjectCCDS24855.1
International Mouse Knockout Project StatusMyh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005918 VEGA Gene Model | MGI Sequence Detail 24524 C57BL/6J ±  kb
transcript OTTMUST00000013178 VEGA | MGI Sequence Detail 6081 Not Applicable 
polypeptide OTTMUSP00000006115 VEGA | MGI Sequence Detail 1942 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(7)
Polymorphisms SNPs within 2kb(317 from dbSNP Build 137)    SNPs within 2kb including multiple locations(327)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027401 Myosin-like IQ motif-containing domain
InterPro IPR004009 Myosin, N-terminal, SH3-like
InterPro IPR008989 Myosin S1 fragment, N-terminal
InterPro IPR002928 Myosin tail
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010820 myosin-1
References (Earliest) J:7154 Leinwand LA, et al., Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome. Science. 1983 Aug 19;221(4612):766-9
(Latest) J:206594 Daou N, et al., A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis. Development. 2013 Dec;140(24):4914-25
All references(72)
Other
accession IDs
MGD-MRK-12755, MGD-MRK-12757, MGD-MRK-12761, MGI:2441807, MGI:97264

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory