S100a10
Gene Detail

Symbol Name ID

S100a10 S100 calcium binding protein A10 (calpactin) MGI:1339468

Synonyms

42C, CAL12, Cal1l, CLP11, p10

Feature Type

protein coding gene

Genetic Map

Chromosome 3

40.51 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr3:93555080-93564643 bp, + strand From VEGA annotation of GRCm38   9564 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2228  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: S-100 protein
Gene Tree: S100a10

Human homologs

Human Homolog		S100A10, S100 calcium binding protein A10
NCBI Gene ID		6281
neXtProt AC		NX_P60903
Human Synonyms		42C, ANX2L, ANX2LG, Ca[1], CAL1L, CLP11, GP11, p10, P11
Human Chr (Location)		1q21; chr1:151955386-151966714 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(39) : Targeted(3) Gene trapped(36)
 

Mice homozygous for a knock-out allele display a depression-like phenotype, decreased responsiveness to 5-HT1B receptor agonists, and reduced behavioral reactions to an antidepressant.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	cellular response to acid, positive regulation of binding
Component	endoplasmic reticulum, extrinsic to plasma membrane
Function	calcium ion binding

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (567)    Tissues (171)    Images (86)
Theiler Stages: 17, 19, 22, 23, 28

Assay Type	Results
RNA in situ	565
RT-PCR	2

cDNA source data(148)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(153) cDNA(149) Primer pair(3) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000022124 (Evidence)
Ensembl Gene Model	ENSMUSG00000041959 (Evidence)
Entrez Gene	20194 (Evidence)
UniGene	1
DFCI	TC1574176, TC1610278
DoTS	DT.111050644, DT.536535, DT.55282592
NIA Mouse Gene Index	U003534
Consensus CDS Project	CCDS38526.1
International Mouse Knockout Project Status	S100a10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022124	VEGA Gene Model | MGI Sequence Detail	9564	C57BL/6J
transcript	OTTMUST00000090262	VEGA | MGI Sequence Detail	477	Not Applicable
polypeptide	OTTMUSP00000049477	VEGA | MGI Sequence Detail	97	Not Applicable

All sequences(36) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(67 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002048	EF-hand domain
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR013787	S100/CaBP-9k-type, calcium binding, subdomain
InterPro	IPR001751	S100/Calbindin-D9k, conserved site
Protein Ontology	PR:000014403	protein S100-A10

References

(Earliest) J:8809 Saris CJ, et al., cDNA sequence and tissue distribution of the mRNA for bovine and murine p11, the S100-related light chain of the protein-tyrosine kinase substrate p36 (calpactin I). J Biol Chem. 1987 Aug 5;262(22):10663-71
(Latest) J:186397 Warner-Schmidt JL, et al., Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11360-5
All references(62)

Other accession IDs

MGD-MRK-1728, MGI:2139574, MGI:2139857, MGI:88247