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S100a10 Gene Detail
Summary
  • Symbol
    S100a10
  • Name
    S100 calcium binding protein A10 (calpactin)
  • Synonyms
    42C, CAL12, Cal1l, CLP11, p10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339468
    NCBI Gene: 20194
  • Gene Overview
    MyGene.info: S100A10
Location & Maps
more
  • Sequence Map
    Chr3:93555080-93564643 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9564 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.51 cM, cytoband F1-F2
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    S100A10, S100 calcium binding protein A10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    S100A10, S100 calcium binding protein A10
    Orthology source: HomoloGene
  • Synonyms
    42C, ANX2L, ANX2LG, Ca[1], CAL1L, CLP11, GP11, p10, P11
  • Links
    NCBI Gene ID: 6281
    neXtProt AC: NX_P60903

  • Chr Location
    1q21; chr1:151982910-151994238 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    43
  • Chemically induced (other)
    1
  • Gene trapped
    36
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving S100a10
Mice homozygous for a knock-out allele display a depression-like phenotype, decreased responsiveness to 5-HT1B receptor agonists, and reduced behavioral reactions to an antidepressant.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022124 VEGA Gene Model | MGI Sequence Detail 9564 C57BL/6J ±  kb
transcript OTTMUST00000052509 VEGA | MGI Sequence Detail 685 Not Applicable  
polypeptide OTTMUSP00000024909 VEGA | MGI Sequence Detail 97 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    132 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 152
    cDNA 148
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1728, MGI:2139574, MGI:2139857, MGI:88247
References
more
  • Summaries
    All 66
    Developmental Gene Expression 12
    Gene Ontology 5
    Phenotypes 20
  • Earliest
    J:8809 Saris CJ, et al., cDNA sequence and tissue distribution of the mRNA for bovine and murine p11, the S100-related light chain of the protein-tyrosine kinase substrate p36 (calpactin I). J Biol Chem. 1987 Aug 5;262(22):10663-71
  • Latest
    J:229971 Schintu N, et al., p11 modulates L-DOPA therapeutic effects and dyskinesia via distinct cell types in experimental Parkinsonism. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1429-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory