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S100a9
Gene Detail
 Symbol
Name
ID
S100a9
S100 calcium binding protein A9 (calgranulin B)
MGI:1338947
Synonyms 60B8Ag, BEE22, Cagb, GAGB, L1Ag, MRP14, p14
Feature Type protein coding gene
Genetic Map
Chromosome 3
39.91 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:90692632-90695721 bp, - strand
From VEGA annotation of GRCm38

  3090 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2227  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: S-100 protein
Gene Tree: S100a9

Human
homologs
Human Homolog S100A9, S100 calcium binding protein A9
NCBI Gene ID 6280
neXtProt AC  NX_P06702
Human Synonyms  60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14
Human Chr (Location)  1q21; chr1:153357854-153361027 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one null allele exhibit abnormal immune physiology.
 
Interactions
S100a9 interacts with 21 markers (Mir15a, Mir92-1, Mir184, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process actin cytoskeleton reorganization, activation of cysteine-type endopeptidase activity involved in apoptotic process, ...
Component cytoplasm, cytoskeleton, ...
Function antioxidant activity, arachidonic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (138)    Tissues (21)    Images (31)
Theiler Stages: 9, 10, 11, 12, 19, 21, 23, 28
Assay TypeResults
RNA in situ 124
Western blot 4
RT-PCR 10
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(2) cDNA(24) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026669 (Evidence)
Ensembl Gene ModelENSMUSG00000056071 (Evidence)
Entrez Gene20202 (Evidence)
UniGene2128
DFCITC1578387
DoTSDT.103588551, DT.87069147
NIA Mouse Gene IndexU024303
Consensus CDS ProjectCCDS17543.1
International Mouse Knockout Project StatusS100a9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026669 VEGA Gene Model | MGI Sequence Detail 3090 C57BL/6J ±  kb
transcript OTTMUST00000065991 VEGA | MGI Sequence Detail 512 Not Applicable 
polypeptide OTTMUSP00000032972 VEGA | MGI Sequence Detail 113 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR013787 S100/CaBP-9k-type, calcium binding, subdomain
InterPro IPR001751 S100/Calbindin-D9k, conserved site
Protein Ontology PR:000014418 protein S100-A9
References (Earliest) J:1255 Lagasse E, et al., Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage. Blood. 1992 Apr 15;79(8):1907-15
(Latest) J:209808 Yano J, et al., Vaginal epithelial cell-derived S100 alarmins induced by Candida albicans via pattern recognition receptor interactions are sufficient but not necessary for the acute neutrophil response during experimental vaginal candidiasis. Infect Immun. 2014 Feb;82(2):783-92
All references(84)
Other
accession IDs
MGD-MRK-1726, MGI:2139998, MGI:88245

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory