S100a9
Gene Detail

Symbol Name ID

S100a9 S100 calcium binding protein A9 (calgranulin B) MGI:1338947

Synonyms

60B8Ag, BEE22, Cagb, GAGB, L1Ag, MRP14, p14

Feature Type

protein coding gene

Genetic Map

Chromosome 3

39.91 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr3:90692632-90695721 bp, - strand From VEGA annotation of GRCm38   3090 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2227  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: S-100 protein
Gene Tree: S100a9

Human homologs

Human Homolog		S100A9, S100 calcium binding protein A9
NCBI Gene ID		6280
neXtProt AC		NX_P06702
Human Synonyms		60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14
Human Chr (Location)		1q21; chr1:153330330-153333503 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for one null allele exhibit abnormal immune physiology.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	actin cytoskeleton reorganization, activation of cysteine-type endopeptidase activity involved in apoptotic process, ...
Component	cytoplasm, cytoskeleton, ...
Function	antioxidant activity, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (121)    Tissues (14)    Images (24)
Theiler Stages: 19, 21, 23, 28

Assay Type	Results
RNA in situ	118
RT-PCR	3

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(2) cDNA(23) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026669 (Evidence)
Ensembl Gene Model	ENSMUSG00000056071 (Evidence)
Entrez Gene	20202 (Evidence)
UniGene	2128
DFCI	TC1578387
DoTS	DT.103588551, DT.87069147
NIA Mouse Gene Index	U024303
Consensus CDS Project	CCDS17543.1
International Mouse Knockout Project Status	S100a9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026669	VEGA Gene Model | MGI Sequence Detail	3090	C57BL/6J
transcript	OTTMUST00000065991	VEGA | MGI Sequence Detail	512	Not Applicable
polypeptide	OTTMUSP00000032972	VEGA | MGI Sequence Detail	113	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(5 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018249	EF-HAND 2
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR013787	S100/CaBP-9k-type, calcium binding, subdomain
InterPro	IPR001751	S100/Calbindin-D9k, conserved site
Protein Ontology	PR:000014418	protein S100-A9

References

(Earliest) J:1255 Lagasse E, et al., Mouse MRP8 and MRP14, two intracellular calcium-binding proteins associated with the development of the myeloid lineage. Blood. 1992 Apr 15;79(8):1907-15
(Latest) J:194114 Hibino T, et al., S100A9 is a novel ligand of EMMPRIN that promotes melanoma metastasis. Cancer Res. 2013 Jan 1;73(1):172-83
All references(72)

Other accession IDs

MGD-MRK-1726, MGI:2139998, MGI:88245