S100a1
Gene Detail

Symbol Name ID

S100a1 S100 calcium binding protein A1 MGI:1338917

Synonyms

S100, S100a

Feature Type

protein coding gene

Genetic Map

Chromosome 3

39.24 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr3:90511034-90514392 bp, - strand From VEGA annotation of GRCm38   3359 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4566  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: S-100 protein
Gene Tree: S100a1

Human homologs

Human Homolog		S100A1, S100 calcium binding protein A1
NCBI Gene ID		6271
neXtProt AC		NX_P23297
Human Synonyms		S100, S100A, S100-alpha
Human Chr (Location)		1q21; chr1:153600873-153604512 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(19) : Targeted(4) Gene trapped(15)
 

Homozygous and heterozygous mice exhibit a reduced cardiac contractility in response to chronic hemodynamic stress.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	negative regulation of transcription from RNA polymerase II promoter, positive regulation of voltage-gated calcium channel activity
Component	A band, cytoplasm, ...
Function	ATPase binding, calcium-dependent protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (25)    Tissues (4)    Images (22)
Theiler Stages: 21, 23, 24

Assay Type	Results
RNA in situ	23
RT-PCR	2

cDNA source data(110)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(113) Genomic(1) cDNA(111) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000022107 (Evidence)
Ensembl Gene Model	ENSMUSG00000044080 (Evidence)
Entrez Gene	20193 (Evidence)
UniGene	24662
DFCI	TC1575391
DoTS	DT.536365, DT.99846420
NIA Mouse Gene Index	U024302
Consensus CDS Project	CCDS38503.1
International Mouse Knockout Project Status	S100a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022107	VEGA Gene Model | MGI Sequence Detail	3359	C57BL/6J
transcript	OTTMUST00000052482	VEGA | MGI Sequence Detail	677	Not Applicable
polypeptide	OTTMUSP00000024891	VEGA | MGI Sequence Detail	94	Not Applicable

All sequences(31) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR002048	EF-hand domain
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR013787	S100/CaBP-9k-type, calcium binding, subdomain
InterPro	IPR001751	S100/Calbindin-D9k, conserved site
Protein Ontology	PR:000014402	protein S100-A1

References

(Earliest) J:52324 Ridinger K, et al., Clustered organization of S100 genes in human and mouse. Biochim Biophys Acta. 1998 Dec 10;1448(2):254-63
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(66)

Other accession IDs

MGI:2139656