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S100a1
Gene Detail
 Symbol
Name
ID
S100a1
S100 calcium binding protein A1
MGI:1338917
Synonyms S100, S100a
Feature Type protein coding gene
Genetic Map
Chromosome 3
39.24 cM, cytoband F1-F2
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:90511034-90514392 bp, - strand
From VEGA annotation of GRCm38

  3359 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4566  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: S-100 protein
Gene Tree: S100a1

Human
homologs
Human Homolog S100A1, S100 calcium binding protein A1
NCBI Gene ID 6271
neXtProt AC  NX_P23297
Human Synonyms  S100, S100A, S100-alpha
Human Chr (Location)  1q21; chr1:153628397-153632037 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(15) Targeted(4)
Incidental mutations (data from Mutagenetix )
 
Homozygous and heterozygous mice exhibit a reduced cardiac contractility in response to chronic hemodynamic stress.
 
Interactions
S100a1 interacts with 60 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process negative regulation of transcription from RNA polymerase II promoter, positive regulation of voltage-gated calcium channel activity, ...
Component A band, cytoplasm, ...
Function ATPase binding, calcium-dependent protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (25)    Tissues (4)    Images (22)
Theiler Stages: 21, 23, 24
Assay TypeResults
RNA in situ 23
RT-PCR 2
cDNA source data(111)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(114) Genomic(1) cDNA(112) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000022107 (Evidence)
Ensembl Gene ModelENSMUSG00000044080 (Evidence)
Entrez Gene20193 (Evidence)
UniGene24662
DFCITC1575391
DoTSDT.536365, DT.99846420
NIA Mouse Gene IndexU024302
Consensus CDS ProjectCCDS38503.1
International Mouse Knockout Project StatusS100a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022107 VEGA Gene Model | MGI Sequence Detail 3359 C57BL/6J ±  kb
transcript OTTMUST00000052482 VEGA | MGI Sequence Detail 677 Not Applicable 
polypeptide OTTMUSP00000024891 VEGA | MGI Sequence Detail 94 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR013787 S100/CaBP-9k-type, calcium binding, subdomain
InterPro IPR001751 S100/Calbindin-D9k, conserved site
Protein Ontology PR:000014402 protein S100-A1
References (Earliest) J:52324 Ridinger K, et al., Clustered organization of S100 genes in human and mouse. Biochim Biophys Acta. 1998 Dec 10;1448(2):254-63
(Latest) J:207851 Li S, et al., Expression analysis of ATAD3 isoforms in rodent and human cell lines and tissues. Gene. 2014 Feb 1;535(1):60-9
All references(68)
Other
accession IDs
MGI:2139656

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory