S100a5 Gene Detail

Summary

• Symbol
  S100a5
• Name
  S100 calcium binding protein A5
• Synonyms
  S100D9

• Feature Type
  protein coding gene
• IDs
  MGI:1338915
  NCBI Gene: 20199
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr3:90515830-90519087 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 39.27 cM, cytoband F1-F2
• Mapping Data
  5 experiments

Strain
Comparison

• SNPs within 2kb
  54 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338915	protein coding gene	Chr3:90513787-90519091 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027476	protein coding gene	Chr3:90941517-90944772 (+)
A/J	MGP_AJ_G0027440	protein coding gene	Chr3:87905108-87908421 (+)
AKR/J	MGP_AKRJ_G0027405	protein coding gene	Chr3:90071139-90074394 (+)
BALB/cJ	MGP_BALBcJ_G0027449	protein coding gene	Chr3:87862167-87865418 (+)
C3H/HeJ	MGP_C3HHeJ_G0027191	protein coding gene	Chr3:90232871-90236110 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027895	protein coding gene	Chr3:94345091-94348344 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025248	protein coding gene	Chr3:83407171-83410424 (+)
CAST/EiJ	MGP_CASTEiJ_G0026637	protein coding gene	Chr3:90630159-90633388 (+)
CBA/J	MGP_CBAJ_G0027166	protein coding gene	Chr3:97551437-97554692 (+)
DBA/2J	MGP_DBA2J_G0027303	protein coding gene	Chr3:87270448-87273687 (+)
FVB/NJ	MGP_FVBNJ_G0027271	protein coding gene	Chr3:85600859-85604116 (+)
LP/J	MGP_LPJ_G0027412	protein coding gene	Chr3:91997474-92000731 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027292	protein coding gene	Chr3:103794332-103797583 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027954	protein coding gene	Chr3:89818677-89821918 (+)
PWK/PhJ	MGP_PWKPhJ_G0026371	protein coding gene	Chr3:87170014-87173261 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026191	protein coding gene	Chr3:88999440-89002687 (+)
WSB/EiJ	MGP_WSBEiJ_G0026719	protein coding gene	Chr3:90224558-90227783 (+)

Homology

• Human Ortholog
  S100A5, S100 calcium binding protein A5

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  S100A5, S100 calcium binding protein A5
  
• Synonyms
  S100D
• Links
  HGNC:10495

  NCBI Gene ID: 6276

  neXtProt AC: NX_P33763

  UniProt: P33763

  
  
• Chr Location
  1q21.3; chr1:153537147-153543685 (-)  GRCh38

---

• MGI Vertebrate Homology
  S100a5 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: S100A5
• Gene Tree
  S100a5
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype from multigenic genotypes
  9 phenotype references
  

• All Mutations and Alleles
  10
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Gene trapped
  1
• Radiation induced
  1
• Targeted
  6
• Genomic Mutations
  2 involving S100a5
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  7 strains or lines available

Mice homozygous for a null allele are indistinguishable from wild-type littermates.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  13
• GO References
  5

Expression

• Assay Results
  706
• cDNA Data
  4
• Literature Summary
  1

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  44
• RefSeq
  14
• UniProt
  2
• CCDS
  CCDS38505.1

• Ensembl
  ENSMUSG00000001023 (Evidence)
• NCBI Gene
  20199

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000001023	Ensembl Gene Model | MGI Sequence Detail	3258	C57BL/6J
transcript	ENSMUST00000001049	Ensembl | MGI Sequence Detail	422	Not Applicable
polypeptide	ENSMUSP00000001049	Ensembl | MGI Sequence Detail	93	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000014412 protein S100-A5
  (term hierarchy)
• InterPro Domains
  IPR018247 EF-Hand 1, calcium-binding site
  IPR002048 EF-hand domain
  IPR011992 EF-hand domain pair
  IPR034325 S-100
  IPR013787 S100/CaBP-9k-type, calcium binding, subdomain
  IPR001751 S100/Calcium binding protein 7/8-like, conserved site

Molecular
Reagents

• All nucleic 5

  Genomic 1

  cDNA 4

  
  

  Microarray probesets 3

References

• Summaries
  All 35

  Developmental Gene Expression 1

  Diseases 1

  Gene Ontology 5

  Phenotypes 9
• Earliest
  J:52324 Ridinger K, et al., Clustered organization of S100 genes in human and mouse. Biochim Biophys Acta. 1998 Dec 10;1448(2):254-63
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for S100a5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30240	Chr3:90515804-90515808 (+)	-24 bp
Tssr30241	Chr3:90516686-90516702 (+)	864 bp