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Padi2
Gene Detail
 Symbol
Name
ID
Padi2
peptidyl arginine deiminase, type II
MGI:1338892
Synonyms mKIAA0994, PAD type II, Pdi, Pdi2
Feature Type protein coding gene
Genetic Map
Chromosome 4
73.01 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:140906344-140952586 bp, + strand
From VEGA annotation of GRCm38

  46243 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7214  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: protein-arginine deiminase
Gene Tree: Padi2

Human
homologs
Human Homolog PADI2, peptidyl arginine deiminase, type II
NCBI Gene ID 11240
neXtProt AC  NX_Q9Y2J8
Human Synonyms  PAD2, PAD-H19, PDI2
Human Chr (Location)  1p36.13; chr1:17066761-17119453 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(15) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired ATP- or calcium ionophore ionomycin-induced citrullination of mast cells or of proteins following induction of EAE.
 
Interactions
Padi2 interacts with 290 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cellular protein modification process, chromatin-mediated maintenance of transcription, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function calcium ion binding, estrogen receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (154)    Tissues (110)   
Theiler Stages: 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 94
Western blot 19
RT-PCR 35
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000010085 (Evidence)
Ensembl Gene ModelENSMUSG00000028927 (Evidence)
Entrez Gene18600 (Evidence)
NIA Mouse Gene IndexU005028
EC3.5.3.15
Consensus CDS ProjectCCDS18857.1
International Mouse Knockout Project StatusPadi2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010085 VEGA Gene Model | MGI Sequence Detail 46243 C57BL/6J ±  kb
transcript OTTMUST00000023446 VEGA | MGI Sequence Detail 4774 Not Applicable 
polypeptide OTTMUSP00000010714 VEGA | MGI Sequence Detail 673 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(6) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(445 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008972 Cupredoxin
InterPro IPR004303 Protein-arginine deiminase
InterPro IPR013530 Protein-arginine deiminase, C-terminal
InterPro IPR013733 Protein-arginine deiminase (PAD), central domain
InterPro IPR013732 Protein-arginine deiminase (PAD) N-terminal
InterPro IPR016296 Protein-arginine deiminase, subgroup
Protein Ontology PR:000012220 protein-arginine deiminase type-2
References (Earliest) J:22129 Takahara H, et al., Peptidylarginine deiminase of the mouse. Distribution, properties, and immunocytochemical localization. J Biol Chem. 1989 Aug 5;264(22):13361-8
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(48)
Other
accession IDs
MGD-MRK-13221, MGI:97534

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory