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Padi2 Gene Detail
Summary
  • Symbol
    Padi2
  • Name
    peptidyl arginine deiminase, type II
  • Synonyms
    mKIAA0994, PAD type II, Pdi, Pdi2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338892
    NCBI Gene: 18600
  • Gene Overview
    MyGene.info: PADI2
Location & Maps
more
  • Sequence Map
    Chr4:140906344-140952586 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46243 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 73.01 cM, cytoband E1
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    PADI2, peptidyl arginine deiminase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PADI2, peptidyl arginine deiminase 2
    Orthology source: HomoloGene
  • Synonyms
    PAD2, PAD-H19, PDI2
  • Links
    NCBI Gene ID: 11240
    neXtProt AC: NX_Q9Y2J8

  • Chr Location
    1p36.13; chr1:17066761-17119453 (-)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Chemically induced (other)
    2
  • Gene trapped
    15
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    3 involving Padi2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit impaired ATP- or calcium ionophore ionomycin-induced citrullination of mast cells or of proteins following induction of EAE.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010085 VEGA Gene Model | MGI Sequence Detail 46243 C57BL/6J ±  kb
transcript OTTMUST00000023446 VEGA | MGI Sequence Detail 4774 Not Applicable  
polypeptide OTTMUSP00000010714 VEGA | MGI Sequence Detail 673 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    439 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012220 protein-arginine deiminase type-2
  • EC
  • InterPro Domains
    IPR008972 Cupredoxin
    IPR004303 Protein-arginine deiminase
    IPR013530 Protein-arginine deiminase, C-terminal
    IPR013733 Protein-arginine deiminase (PAD), central domain
    IPR013732 Protein-arginine deiminase (PAD) N-terminal
Molecular
Reagents
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  • All nucleic 17
    cDNA 15
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13221, MGI:97534
References
more
  • Summaries
    All 46
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:22129 Takahara H, et al., Peptidylarginine deiminase of the mouse. Distribution, properties, and immunocytochemical localization. J Biol Chem. 1989 Aug 5;264(22):13361-8
  • Latest
    J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory