Cacna2d3
Gene Detail

Symbol Name ID

Cacna2d3 calcium channel, voltage-dependent, alpha2/delta subunit 3 MGI:1338890

Synonyms

alpha2delta3, alpha 2 delta-3

Feature Type

protein coding gene

Genetic Map

Chromosome 14

16.80 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr14:28904947-29721864 bp, - strand From Ensembl annotation of GRCm38   816918 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74929  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: voltage-dependent calcium channel fused subunit
Gene Tree: Cacna2d3

Human homologs

Human Homolog		CACNA2D3, calcium channel, voltage-dependent, alpha 2/delta subunit 3
NCBI Gene ID		55799
neXtProt AC		NX_Q8IZS8
Human Synonyms		HSA272268
Human Chr (Location)		3p21.1; chr3:54156693-55108584 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for disruptions in this gene have a decreased startle reflex and occasional animals show increased aggression and hyperactivity.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	integral to membrane, membrane
Function	calcium channel activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (257)    Tissues (69)    Images (34)
Theiler Stages: 23, 24, 25, 28

Assay Type	Results
RNA in situ	151
In situ reporter (knock in)	54
RT-PCR	52

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(15) Primer pair(3) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000021991 (Evidence)
Entrez Gene	12294 (Evidence)
UniGene	386754
DFCI	TC1585796
DoTS	DT.87068382
NIA Mouse Gene Index	U035350
International Mouse Knockout Project Status	Cacna2d3

Sequences

Length	Strain/Species
genomic	ENSMUSG00000021991	Ensembl Gene Model | MGI Sequence Detail	816918	C57BL/6J
transcript	ENSMUST00000022567	Ensembl | MGI Sequence Detail	3691	Not Applicable
polypeptide	ENSMUSP00000022567	Ensembl | MGI Sequence Detail	1091	Not Applicable

All sequences(13) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(4699 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004010	Cache domain
InterPro	IPR002035	von Willebrand factor, type A
InterPro	IPR013608	VWA N-terminal
Protein Ontology	PR:000004944	voltage-dependent calcium channel subunit alpha-2/delta-3

References

(Earliest) J:52012 Klugbauer N, et al., Molecular diversity of the calcium channel alpha2delta subunit. J Neurosci. 1999 Jan 15;19(2):684-91
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(35)