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Cacna2d3 Gene Detail
Summary
  • Symbol
    Cacna2d3
  • Name
    calcium channel, voltage-dependent, alpha2/delta subunit 3
  • Synonyms
    alpha2delta3, alpha 2 delta-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338890
    NCBI Gene: 12294
Location & Maps
more
  • Sequence Map
    Chr14:28904943-29721864 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      816922 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 16.80 cM, cytoband B
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CACNA2D3, calcium voltage-gated channel auxiliary subunit alpha2delta 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CACNA2D3, calcium voltage-gated channel auxiliary subunit alpha2delta 3
    Orthology source: HomoloGene
  • Synonyms
    HSA272268
  • Links
    NCBI Gene ID: 55799
    neXtProt AC: NX_Q8IZS8

  • Chr Location
    3p21.1; chr3:54122593-55074557 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a decreased startle reflex and occasional animals show increased aggression and hyperactivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046735 VEGA Gene Model | MGI Sequence Detail 816922 C57BL/6J ±  kb
transcript OTTMUST00000121364 VEGA | MGI Sequence Detail 3695 Not Applicable  
polypeptide OTTMUSP00000066907 VEGA | MGI Sequence Detail 1091 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    5512 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004944 voltage-dependent calcium channel subunit alpha-2/delta-3
  • InterPro Domains
    IPR013680 Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region
    IPR002035 von Willebrand factor, type A
    IPR013608 VWA N-terminal
Molecular
Reagents
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  • All nucleic 18
    cDNA 13
    Primer pair 3
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 11
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:52012 Klugbauer N, et al., Molecular diversity of the calcium channel alpha2delta subunit. J Neurosci. 1999 Jan 15;19(2):684-91
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory