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Cacna2d3 Gene Detail
Summary
  • Symbol
    Cacna2d3
  • Name
    calcium channel, voltage-dependent, alpha2/delta subunit 3
  • Synonyms
    alpha2delta3, alpha 2 delta-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338890
    NCBI Gene: 12294
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:28904943-29721864 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      816922 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 16.80 cM, cytoband B
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CACNA2D3, calcium voltage-gated channel auxiliary subunit alpha2delta 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CACNA2D3, calcium voltage-gated channel auxiliary subunit alpha2delta 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSA272268
  • Links
    NCBI Gene ID: 55799
    neXtProt AC: NX_Q8IZS8
    UniProt: Q8IZS8

  • Chr Location
    3p21.1-p14.3; chr3:54122594-55074557 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a decreased startle reflex and occasional animals show increased aggression and hyperactivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    • UniGene
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000046735 VEGA Gene Model | MGI Sequence Detail 816922 C57BL/6J ±  kb
    transcript OTTMUST00000121364 VEGA | MGI Sequence Detail 3695 Not Applicable  
    polypeptide OTTMUSP00000066907 VEGA | MGI Sequence Detail 1091 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      5512 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000004944 voltage-dependent calcium channel subunit alpha-2/delta-3
    • InterPro Domains
      IPR013680 Voltage-dependent calcium channel, alpha-2/delta subunit, conserved region
      IPR036465 von Willebrand factor A-like domain superfamily
      IPR002035 von Willebrand factor, type A
      IPR013608 VWA N-terminal
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 14
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:52012 Klugbauer N, et al., Molecular diversity of the calcium channel alpha2delta subunit. J Neurosci. 1999 Jan 15;19(2):684-91
    • Latest
      J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory