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Cacna2d3
Gene Detail
Symbol

Name
ID
Cacna2d3
calcium channel, voltage-dependent, alpha2/delta subunit 3
MGI:1338890
Synonyms
alpha2delta3, alpha 2 delta-3
Feature Type
protein coding gene
Genetic Map
Chromosome 14
16.80 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:28904943-29721864 bp, - strand
From VEGA annotation of GRCm38

  816922 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74929  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: voltage-dependent calcium channel fused subunit
Gene Tree: Cacna2d3

Human
homologs
Human Homolog CACNA2D3, calcium channel, voltage-dependent, alpha 2/delta subunit 3
NCBI Gene ID 55799
neXtProt AC  NX_Q8IZS8
Human Synonyms  HSA272268
Human Chr (Location)  3p21.1; chr3:54122593-55074557 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have a decreased startle reflex and occasional animals show increased aggression and hyperactivity.
 
Interactions
Cacna2d3 interacts with 122 markers (Mir17, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component integral component of membrane, membrane
Function calcium channel activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (257)    Tissues (72)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 151
In situ reporter (knock in) 54
RT-PCR 52
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(13) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000046735 (Evidence)
Ensembl Gene ModelENSMUSG00000021991 (Evidence)
Entrez Gene12294 (Evidence)
UniGene386754
DFCITC1585796
DoTSDT.87068382
NIA Mouse Gene IndexU035350
International Mouse Knockout Project StatusCacna2d3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046735 VEGA Gene Model | MGI Sequence Detail 816922 C57BL/6J ±  kb
transcript OTTMUST00000121364 VEGA | MGI Sequence Detail 3695 Not Applicable 
polypeptide OTTMUSP00000066907 VEGA | MGI Sequence Detail 1091 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(5565 from dbSNP Build 137)    SNPs within 2kb including multiple locations(5567)
Protein-related
information
ResourceIDDescription
InterPro IPR004010 Cache domain
InterPro IPR002035 von Willebrand factor, type A
InterPro IPR013608 VWA N-terminal
Protein Ontology PR:000004944 voltage-dependent calcium channel subunit alpha-2/delta-3
References
(Earliest) J:52012 Klugbauer N, et al., Molecular diversity of the calcium channel alpha2delta subunit. J Neurosci. 1999 Jan 15;19(2):684-91
(Latest) J:206966 Etemad S, et al., Differential neuronal targeting of a new and two known calcium channel beta4 subunit splice variants correlates with their regulation of gene expression. J Neurosci. 2014 Jan 22;34(4):1446-61
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory