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Gfpt2 Gene Detail
Summary
  • Symbol
    Gfpt2
  • Name
    glutamine fructose-6-phosphate transaminase 2
  • Synonyms
    GFAT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338883
    NCBI Gene: 14584
Location & Maps
more
  • Sequence Map
    Chr11:49794178-49838613 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      44436 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 29.90 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GFPT2, glutamine-fructose-6-phosphate transaminase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GFPT2, glutamine-fructose-6-phosphate transaminase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GFAT, GFAT2, GFAT 2
  • Links
    NCBI Gene ID: 9945
    neXtProt AC: NX_O94808

  • Chr Location
    5q35.3; chr5:180300698-180353336 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    74
  • Chemically induced (other)
    1
  • Gene trapped
    69
  • Targeted
    4
  • Genomic Mutations
    1 involving Gfpt2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005570 VEGA Gene Model | MGI Sequence Detail 44436 C57BL/6J ±  kb
transcript OTTMUST00000012376 VEGA | MGI Sequence Detail 2947 Not Applicable  
polypeptide OTTMUSP00000005729 VEGA | MGI Sequence Detail 682 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    134 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007947 glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2
  • EC
  • InterPro Domains
    IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising
    IPR017932 Glutamine amidotransferase type 2 domain
    IPR029055 Nucleophile aminohydrolases, N-terminal
    IPR001347 Sugar isomerase (SIS)
Molecular
Reagents
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  • All nucleic 39
    Genomic 2
    cDNA 35
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144189
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:39516 Sayeski PP, et al., Cloning and partial characterization of the mouse glutamine:fructose-6-phosphate amidotransferase (GFAT) gene promoter. Nucleic Acids Res. 1997 Apr 1;25(7):1458-66
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory