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Pex11b
Gene Detail
Symbol

Name
ID
Pex11b
peroxisomal biogenesis factor 11 beta
MGI:1338882
Feature Type
protein coding gene
Genetic Map
Chromosome 3
41.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:96635376-96653101 bp, + strand
From VEGA annotation of GRCm38

  17726 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2852  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PEX11B
Gene Tree: Pex11b

Human
homologs
PEX11B, peroxisomal biogenesis factor 11 beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8799
neXtProt AC: NX_O96011

Human Synonyms: PEX11-BETA, PEX14B

Human Chr (Location): 1q21.1; chr1:145911348-145918924 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PEX11B

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Targeted(3)
 
Mice homozygous for disruptions in this gene die within the first day of life. Various abnormalities develop as a result of peroxisomal abnormalities. The condition is similar to Zellweger Syndrome.
 
Interactions
Pex11b interacts with 275 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process peroxisome fission, peroxisome organization, ...
Component extracellular exosome, integral component of membrane, ...
Function protein homodimerization activity
External Resources: FuncBase
Expression
cDNA source data(62)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pex11b    NEW 
Molecular
reagents
All nucleic(65) Genomic(1) cDNA(63) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000029574 (Evidence)
Ensembl Gene Model ENSMUSG00000028102 (Evidence)
Entrez Gene 18632 (Evidence)
UniGene 20901
DFCI TC1620135, TC1592729, TC1575732, TC1611685, TC1688821
DoTS DT.101226263, DT.101321390, DT.55232459, DT.101346891
Consensus CDS Project CCDS17643.1, CCDS51006.1
International Mouse Phenotyping Consortium Status Pex11b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029574 VEGA Gene Model | MGI Sequence Detail 17726 C57BL/6J ±  kb
transcript OTTMUST00000073364 VEGA | MGI Sequence Detail 3624 Not Applicable 
polypeptide OTTMUSP00000037955 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(95 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR008733 Peroxisomal biogenesis factor 11
Protein Ontology PR:000012556 peroxisomal membrane protein 11B
References
(Earliest) J:50862 Schrader M, et al., Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli. J Biol Chem. 1998 Nov 6;273(45):29607-14
(Latest) J:180632 Ahlemeyer B, et al., Deletion of a single allele of the Pex11beta gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain. Dis Model Mech. 2012 Jan;5(1):125-40
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory