About   Help   FAQ
Pex11b
Gene Detail
Symbol

Name
ID
Pex11b
peroxisomal biogenesis factor 11 beta
MGI:1338882
Feature Type
protein coding gene
Genetic Map
Chromosome 3
41.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:96635376-96653101 bp, + strand
From VEGA annotation of GRCm38

  17726 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2852  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Pex11b

Human
homologs
Human Homolog PEX11B, peroxisomal biogenesis factor 11 beta
NCBI Gene ID 8799
neXtProt AC  NX_O96011
Human Synonyms  PEX11-BETA, PEX14B
Human Chr (Location)  1q21.1; chr1:145911348-145918924 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PEX11B
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Targeted(3)
 
Mice homozygous for disruptions in this gene die within the first day of life. Various abnormalities develop as a result of peroxisomal abnormalities. The condition is similar to Zellweger Syndrome.
 
Interactions
Pex11b interacts with 275 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process peroxisome fission, peroxisome organization, ...
Component extracellular vesicular exosome, integral component of membrane, ...
Function protein homodimerization activity
External Resources: FuncBase
Expression
cDNA source data(62)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(65) Genomic(1) cDNA(63) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000029574 (Evidence)
Ensembl Gene ModelENSMUSG00000028102 (Evidence)
Entrez Gene18632 (Evidence)
UniGene20901
DFCITC1575732, TC1620135, TC1611685, TC1592729, TC1688821
DoTSDT.55232459, DT.101346891, DT.101226263, DT.101321390
Consensus CDS ProjectCCDS17643.1, CCDS51006.1
International Mouse Knockout Project StatusPex11b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029574 VEGA Gene Model | MGI Sequence Detail 17726 C57BL/6J ±  kb
transcript OTTMUST00000073364 VEGA | MGI Sequence Detail 3624 Not Applicable 
polypeptide OTTMUSP00000037955 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(8) UniProt(9)
Polymorphisms
SNPs within 2kb(95 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013519 Integrin alpha beta-propellor
InterPro IPR008733 Peroxisomal biogenesis factor 11
Protein Ontology PR:000012556 peroxisomal membrane protein 11B
References
(Earliest) J:50862 Schrader M, et al., Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli. J Biol Chem. 1998 Nov 6;273(45):29607-14
(Latest) J:180632 Ahlemeyer B, et al., Deletion of a single allele of the Pex11beta gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain. Dis Model Mech. 2012 Jan;5(1):125-40
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory