About   Help   FAQ
Pex11b Gene Detail
Summary
  • Symbol
    Pex11b
  • Name
    peroxisomal biogenesis factor 11 beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338882
    NCBI Gene: 18632
  • Gene Overview
    MyGene.info: PEX11B
Location & Maps
more
  • Sequence Map
    Chr3:96635376-96645366 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9991 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 41.93 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PEX11B, peroxisomal biogenesis factor 11 beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PEX11B, peroxisomal biogenesis factor 11 beta
    Orthology source: HomoloGene
  • Synonyms
    PEX11-BETA, PEX14B
  • Links
    NCBI Gene ID: 8799
    neXtProt AC: NX_O96011

  • Chr Location
    1q21.1; chr1:145911348-145918924 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PEX11B associations

Human Disease Mouse Models
       Peroxisome Biogenesis Disorder 14b; PEX14B   OMIM: 614920
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Pex11b
Mice homozygous for disruptions in this gene die within the first day of life. Various abnormalities develop as a result of peroxisomal abnormalities. The condition is similar to Zellweger Syndrome.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029574 VEGA Gene Model | MGI Sequence Detail 9991 C57BL/6J ±  kb
transcript OTTMUST00000073341 VEGA | MGI Sequence Detail 2424 Not Applicable  
polypeptide OTTMUSP00000037940 VEGA | MGI Sequence Detail 259 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    67 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012556 peroxisomal membrane protein 11B
  • InterPro Domains
    IPR008733 Peroxisomal biogenesis factor 11
Molecular
Reagents
less
  • All nucleic 65
    Genomic 1
    cDNA 63
    Other 1

    Microarray probesets 6
References
more
  • Summaries
    All 30
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:50862 Schrader M, et al., Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli. J Biol Chem. 1998 Nov 6;273(45):29607-14
  • Latest
    J:180632 Ahlemeyer B, et al., Deletion of a single allele of the Pex11beta gene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain. Dis Model Mech. 2012 Jan;5(1):125-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory