Btrc
Gene Detail

Symbol Name ID

Btrc beta-transducin repeat containing protein MGI:1338871

Synonyms

beta-TrCP, Beta-Trcp1, Fbw1a, SCF b-TRCP, Slimb

Feature Type

protein coding gene

Genetic Map

Chromosome 19

38.75 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:45363734-45533341 bp, + strand From Ensembl annotation of GRCm38   169608 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:39330  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Btrc

Human homologs

Human Homolog		BTRC, beta-transducin repeat containing E3 ubiquitin protein ligase
NCBI Gene ID		8945
neXtProt AC		NX_Q9Y297
Human Synonyms		betaTrCP, BETA-TRCP, bTrCP, bTrCP1, FBW1A, FBXW1, FBXW1A, FWD1
Human Chr (Location)		10q24.32; chr10:103113790-103317078 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(26) : Targeted(4) Gene trapped(22)
 

Embryonic fibroblasts from homozygotes show an increase in polyploidy and apoptosis and decreased cell proliferation. In a second allele, homozygous mutation results in reduced male fertility and abnormal male meiosis with oligozoospermia.

 

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	branching involved in mammary gland duct morphogenesis, cellular response to organic cyclic compound, ...
Component	cytoplasm, nucleus, ...
Function	beta-catenin binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (201)    Tissues (137)    Images (30)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	201

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(19) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000025217 (Evidence)
Entrez Gene	12234 (Evidence)
DFCI	TC1574058, TC1602429, TC1613015, TC1630975, TC1631878, TC1676033, TC1690259
DoTS	DT.101212313, DT.101366784, DT.101368656, DT.40183134, DT.532668, DT.97340153, DT.97372748, DT.97398503, DT.97407422, DT.99851622, DT.99861261, DT.99861271
NIA Mouse Gene Index	U019505
Consensus CDS Project	CCDS29860.1, CCDS38002.1
International Mouse Knockout Project Status	Btrc

Sequences

Length	Strain/Species
genomic	ENSMUSG00000025217	Ensembl Gene Model | MGI Sequence Detail	169608	C57BL/6J
transcript	ENSMUST00000065601	Ensembl | MGI Sequence Detail	6323	Not Applicable
polypeptide	ENSMUSP00000070728	Ensembl | MGI Sequence Detail	605	Not Applicable

All sequences(61) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(778 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR021977	D domain of beta-TrCP
InterPro	IPR001810	F-box domain, cyclin-like
InterPro	IPR020472	G-protein beta WD-40 repeat
InterPro	IPR001680	WD40 repeat
InterPro	IPR019775	WD40 repeat, conserved site
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000004853	F-box/WD repeat-containing protein 1A

References

(Earliest) J:54317 Yaron A, et al., Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature. 1998 Dec 10;396(6711):590-4
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(63)