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Btrc Gene Detail
Summary
  • Symbol
    Btrc
  • Name
    beta-transducin repeat containing protein
  • Synonyms
    beta-TrCP, Beta-Trcp1, Fbw1a, SCF b-TRCP, Slimb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338871
    NCBI Gene: 12234
  • Gene Overview
    MyGene.info: BTRC
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:45363734-45530013 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 38.75 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    851 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338871
protein coding gene Chr19:45363734-45533343 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025187
protein coding gene Chr19:44952244-45138201 (+)
A/J MGP_AJ_G0025164
protein coding gene Chr19:42762886-42934932 (+)
AKR/J MGP_AKRJ_G0025132
protein coding gene Chr19:44137059-44315789 (+)
BALB/cJ MGP_BALBcJ_G0025158
protein coding gene Chr19:42812388-42986624 (+)
C3H/HeJ MGP_C3HHeJ_G0024918
protein coding gene Chr19:44323794-44495039 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025601
protein coding gene Chr19:46090453-46268501 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023015
protein coding gene Chr19:42017219-42187671 (+)
CAST/EiJ MGP_CASTEiJ_G0024383
protein coding gene Chr19:44051756-44234672 (+)
CBA/J MGP_CBAJ_G0024898
protein coding gene Chr19:48394796-48583957 (+)
DBA/2J MGP_DBA2J_G0025030
protein coding gene Chr19:42575615-42746148 (+)
FVB/NJ MGP_FVBNJ_G0024991
protein coding gene Chr19:42356450-42528254 (+)
LP/J MGP_LPJ_G0025116
protein coding gene Chr19:44877456-45054320 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025022
protein coding gene Chr19:47733713-47929506 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025659
protein coding gene Chr19:44216355-44390159 (+)
PWK/PhJ MGP_PWKPhJ_G0024132
protein coding gene Chr19:42494717-42668995 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023936
protein coding gene Chr19:42892633-43077497 (+)
WSB/EiJ MGP_WSBEiJ_G0024453
protein coding gene Chr19:44372965-44546907 (+)



Homology
more
  • Human Ortholog
    BTRC, beta-transducin repeat containing E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    8
  • Human Ortholog
    BTRC, beta-transducin repeat containing E3 ubiquitin protein ligase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    betaTrCP, BETA-TRCP, bTrCP, bTrCP1, FBW1A, FBXW1, FBXW1A, FWD1
  • Links
    NCBI Gene ID: 8945
    neXtProt AC: NX_Q9Y297
    UniProt: Q9Y297

  • Chr Location
    10q24.32; chr10:101353808-101557321 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryonic fibroblasts from homozygotes show an increase in polyploidy and apoptosis and decreased cell proliferation. In a second allele, homozygous mutation results in reduced male fertility and abnormal male meiosis with oligozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025217 Ensembl Gene Model | MGI Sequence Detail 166280 C57BL/6J ±  kb
    transcript ENSMUST00000065601 Ensembl | MGI Sequence Detail 2978 Not Applicable  
    polypeptide ENSMUSP00000070728 Ensembl | MGI Sequence Detail 605 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 20
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 13
      Gene Ontology 16
      Phenotypes 22
    • Earliest
      J:54317 Yaron A, et al., Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature. 1998 Dec 10;396(6711):590-4
    • Latest
      J:259501 Shimizu K, et al., The SCFbeta-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Sci Signal. 2017 Jan 3;10(460)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory