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Btrc Gene Detail
Summary
  • Symbol
    Btrc
  • Name
    beta-transducin repeat containing protein
  • Synonyms
    beta-TrCP, Beta-Trcp1, Fbw1a, SCF b-TRCP, Slimb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338871
    NCBI Gene: 12234
  • Gene Overview
    MyGene.info: BTRC
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:45363734-45530013 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      166280 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 38.75 cM, cytoband D1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BTRC, beta-transducin repeat containing E3 ubiquitin protein ligase
  • Vertebrate Orthologs
    8
  • Human Ortholog
    BTRC, beta-transducin repeat containing E3 ubiquitin protein ligase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    betaTrCP, BETA-TRCP, bTrCP, bTrCP1, FBW1A, FBXW1, FBXW1A, FWD1
  • Links
    NCBI Gene ID: 8945
    neXtProt AC: NX_Q9Y297
    UniProt: Q9Y297

  • Chr Location
    10q24.32; chr10:101353808-101557321 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryonic fibroblasts from homozygotes show an increase in polyploidy and apoptosis and decreased cell proliferation. In a second allele, homozygous mutation results in reduced male fertility and abnormal male meiosis with oligozoospermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025217 Ensembl Gene Model | MGI Sequence Detail 166280 C57BL/6J ±  kb
    transcript ENSMUST00000065601 Ensembl | MGI Sequence Detail 2978 Not Applicable  
    polypeptide ENSMUSP00000070728 Ensembl | MGI Sequence Detail 605 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      851 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 19
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 12
      Gene Ontology 17
      Phenotypes 22
    • Earliest
      J:54317 Yaron A, et al., Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature. 1998 Dec 10;396(6711):590-4
    • Latest
      J:259501 Shimizu K, et al., The SCFbeta-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Sci Signal. 2017 Jan 3;10(460):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory