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Btrc
Gene Detail
Symbol

Name
ID
Btrc
beta-transducin repeat containing protein
MGI:1338871
Synonyms
beta-TrCP, Beta-Trcp1, Fbw1a, SCF b-TRCP, Slimb
Feature Type
protein coding gene
Genetic Map
Chromosome 19
38.75 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:45363734-45533341 bp, + strand
From Ensembl annotation of GRCm38

  169608 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:39330  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: BTRC
Gene Tree: Btrc

Human
homologs
BTRC, beta-transducin repeat containing E3 ubiquitin protein ligase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8945
neXtProt AC: NX_Q9Y297

Human Synonyms: betaTrCP, BETA-TRCP, bTrCP, bTrCP1, FBW1A, FBXW1, FBXW1A, FWD1

Human Chr (Location): 10q24.32; chr10:101354033-101557321 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(22) Targeted(8) Transgenic(1)
Genomic Mutations involving Btrc (3)
Incidental mutations (data from Mutagenetix , APF )
 
Embryonic fibroblasts from homozygotes show an increase in polyploidy and apoptosis and decreased cell proliferation. In a second allele, homozygous mutation results in reduced male fertility and abnormal male meiosis with oligozoospermia.
 
Interactions
Btrc interacts with 365 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process branching involved in mammary gland duct morphogenesis, cellular response to organic cyclic compound, ...
Component cytoplasm, nucleus, ...
Function beta-catenin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (250)    Tissues (186)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 250
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase btrc    NEW 
Molecular
reagents
All nucleic(21) cDNA(19) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000025217 (Evidence)
Entrez Gene 12234 (Evidence)
DFCI TC1574058, TC1602429, TC1613015, TC1630975, TC1631878, TC1676033, TC1690259
DoTS DT.101212313, DT.101366784, DT.101368656, DT.40183134, DT.532668, DT.97340153, DT.97372748, DT.97398503, DT.97407422, DT.99851622, DT.99861261, DT.99861271
NIA Mouse Gene Index U019505
Consensus CDS Project CCDS29860.1, CCDS38002.1
International Mouse Phenotyping Consortium Status Btrc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025217 Ensembl Gene Model | MGI Sequence Detail 169608 C57BL/6J ±  kb
transcript ENSMUST00000065601 Ensembl | MGI Sequence Detail 6323 Not Applicable 
polypeptide ENSMUSP00000070728 Ensembl | MGI Sequence Detail 605 Not Applicable 

For the selected sequences
All sequences(99) RefSeq(42) UniProt(1)
Polymorphisms
SNPs within 2kb(870 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021977 D domain of beta-TrCP
InterPro IPR001810 F-box domain
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000004853 F-box/WD repeat-containing protein 1A
References
(Earliest) J:54317 Yaron A, et al., Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature. 1998 Dec 10;396(6711):590-4
(Latest) J:206654 Kanarek N, et al., Critical role for IL-1beta in DNA damage-induced mucositis. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E702-11
All references(69)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory