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Btrc
Gene Detail
Symbol

Name
ID
Btrc
beta-transducin repeat containing protein
MGI:1338871
Synonyms
beta-TrCP, Beta-Trcp1, Fbw1a, SCF b-TRCP, Slimb
Feature Type
protein coding gene
Genetic Map
Chromosome 19
38.75 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:45363734-45533341 bp, + strand
From Ensembl annotation of GRCm38

  169608 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:39330  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Btrc

Human
homologs
Human Homolog BTRC, beta-transducin repeat containing E3 ubiquitin protein ligase
NCBI Gene ID 8945
neXtProt AC  NX_Q9Y297
Human Synonyms  betaTrCP, BETA-TRCP, bTrCP, bTrCP1, FBW1A, FBXW1, FBXW1A, FWD1
Human Chr (Location)  10q24.32; chr10:101354033-101557321 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(22) Targeted(8)
Genomic Mutations involving Btrc (3)
Incidental mutations (data from Mutagenetix , APF )
 
Embryonic fibroblasts from homozygotes show an increase in polyploidy and apoptosis and decreased cell proliferation. In a second allele, homozygous mutation results in reduced male fertility and abnormal male meiosis with oligozoospermia.
 
Interactions
Btrc interacts with 366 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process branching involved in mammary gland duct morphogenesis, cellular response to organic cyclic compound, ...
Component cytoplasm, nucleus, ...
Function beta-catenin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (250)    Tissues (186)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 250
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(19) Primer pair(2)
Microarray probesets(4)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025217 Ensembl Gene Model | MGI Sequence Detail 169608 C57BL/6J ±  kb
transcript ENSMUST00000065601 Ensembl | MGI Sequence Detail 6323 Not Applicable 
polypeptide ENSMUSP00000070728 Ensembl | MGI Sequence Detail 605 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(26) UniProt(1)
Polymorphisms
SNPs within 2kb(870 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021977 D domain of beta-TrCP
InterPro IPR001810 F-box domain, cyclin-like
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000004853 F-box/WD repeat-containing protein 1A
References
(Earliest) J:54317 Yaron A, et al., Identification of the receptor component of the IkappaBalpha-ubiquitin ligase. Nature. 1998 Dec 10;396(6711):590-4
(Latest) J:206654 Kanarek N, et al., Critical role for IL-1beta in DNA damage-induced mucositis. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E702-11
All references(69)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory