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Mthfd2
Gene Detail
Symbol

Name
ID
Mthfd2
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
MGI:1338850
Synonyms
NMDMC
Feature Type
protein coding gene
Genetic Map
Chromosome 6
35.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:83305691-83317606 bp, - strand
From VEGA annotation of GRCm38

  11916 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21321  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase
Gene Tree: Mthfd2

Human
homologs
Human Homolog MTHFD2, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NCBI Gene ID 10797
neXtProt AC  NX_P13995
Human Synonyms  NMDMC
Human Chr (Location)  2p13.1; chr2:74198563-74215298 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die as embryos before E15.5.
 
Interactions
Mthfd2 interacts with 143 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process folic acid-containing compound biosynthetic process, metabolic process, ...
Component extracellular space, mitochondrion
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (109)    Tissues (106)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 105
Northern blot 4
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(6) cDNA(17) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023127 (Evidence)
Ensembl Gene ModelENSMUSG00000005667 (Evidence)
Entrez Gene17768 (Evidence)
DFCITC1572912
DoTSDT.494300
NIA Mouse Gene IndexU027524
EC1.5.1.5, 3.5.4.9, 1.5.1.15
Consensus CDS ProjectCCDS20277.1
International Mouse Knockout Project StatusMthfd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023127 VEGA Gene Model | MGI Sequence Detail 11916 C57BL/6J ±  kb
transcript OTTMUST00000055880 VEGA | MGI Sequence Detail 2085 Not Applicable 
polypeptide OTTMUSP00000026807 VEGA | MGI Sequence Detail 350 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
InterPro IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
InterPro IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
InterPro IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
Protein Ontology PR:000010724 bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
References
(Earliest) J:9668 Belanger C, et al., Isolation and characterization of cDNA clones encoding the murine NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase. J Biol Chem. 1989 Mar 25;264(9):4837-43
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)
Other
accession IDs
MGI:2141716

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory