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Pex16 Gene Detail
Summary
  • Symbol
    Pex16
  • Name
    peroxisomal biogenesis factor 16
  • Synonyms
    peroxisome biogenesis factor 16
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338829
    NCBI Gene: 18633
  • Gene Overview
    MyGene.info: PEX16
Location & Maps
more
  • Sequence Map
    Chr2:92374676-92381217 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6542 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.98 cM, cytoband E1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PEX16, peroxisomal biogenesis factor 16
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PEX16, peroxisomal biogenesis factor 16
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PBD8A, PBD8B
  • Links
    NCBI Gene ID: 9409
    neXtProt AC: NX_Q9Y5Y5

  • Chr Location
    11p11.2; chr11:45909669-45918123 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3537
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PEX16
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human PEX16 associations

Human Disease Mouse Models
       Peroxisome Biogenesis Disorder 8a (zellweger); PBD8A   OMIM: 614876
Peroxisome Biogenesis Disorder 8b; PBD8B   OMIM: 614877
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Pex16
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014473 VEGA Gene Model | MGI Sequence Detail 6542 C57BL/6J ±  kb
transcript OTTMUST00000034356 VEGA | MGI Sequence Detail 1392 Not Applicable  
polypeptide OTTMUSP00000015393 VEGA | MGI Sequence Detail 336 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    62 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 5
References
more
  • Summaries
    All 30
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:52366 South ST, et al., Peroxisome synthesis in the absence of preexisting peroxisomes. J Cell Biol. 1999 Jan 25;144(2):255-66
  • Latest
    J:162220 Magdaleno S, et al., BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory