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Rgs9 Gene Detail
Summary
  • Symbol
    Rgs9
  • Name
    regulator of G-protein signaling 9
  • Synonyms
    RGS9-1, Rgs9-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338824
    NCBI Gene: 19739
  • Gene Overview
    MyGene.info: RGS9
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:109225355-109298129 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 71.86 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    356 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338824
protein coding gene Chr11:109225348-109298181 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019330
protein coding gene Chr11:112759257-112838964 (-)
A/J MGP_AJ_G0019298
protein coding gene Chr11:107889377-107962448 (-)
AKR/J MGP_AKRJ_G0019267
protein coding gene Chr11:111118054-111194271 (-)
BALB/cJ MGP_BALBcJ_G0019272
protein coding gene Chr11:108322822-108395870 (-)
C3H/HeJ MGP_C3HHeJ_G0019081
protein coding gene Chr11:111426039-111504752 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019722
protein coding gene Chr11:116176362-116259279 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017346
protein coding gene Chr11:105119684-105189837 (-)
CAST/EiJ MGP_CASTEiJ_G0018635
protein coding gene Chr11:112543874-112623686 (-)
CBA/J MGP_CBAJ_G0019050
protein coding gene Chr11:120974559-121059276 (-)
DBA/2J MGP_DBA2J_G0019162
protein coding gene Chr11:107367388-107442959 (-)
FVB/NJ MGP_FVBNJ_G0019153
protein coding gene Chr11:106857982-106930072 (-)
LP/J MGP_LPJ_G0019232
protein coding gene Chr11:113176605-113252863 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019184
protein coding gene Chr11:120132606-120213436 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019759
protein coding gene Chr11:111677727-111759399 (-)
PWK/PhJ MGP_PWKPhJ_G0018400
protein coding gene Chr11:108525868-108602707 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018190
protein coding gene Chr11:111463104-111538359 (-)
WSB/EiJ MGP_WSBEiJ_G0018686
protein coding gene Chr11:111606650-111683807 (-)



Homology
more
  • Human Ortholog
    RGS9, regulator of G protein signaling 9
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RGS9, regulator of G protein signaling 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PERRS, RGS9L
  • Links
    NCBI Gene ID: 8787
    neXtProt AC: NX_O75916
    UniProt: O75916

  • Chr Location
    17q24.1; chr17:65137338-65227703 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human RGS9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    18 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable and fertile; however, relative to wild-type, homozygous null photoreceptors display abnormally retarded recovery of their light responses, and slowed rates of GTP hydrolysis by transducin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020599 Ensembl Gene Model | MGI Sequence Detail 72775 C57BL/6J ±  kb
    transcript ENSMUST00000020920 Ensembl | MGI Sequence Detail 2434 Not Applicable  
    polypeptide ENSMUSP00000020920 Ensembl | MGI Sequence Detail 675 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 57

      Microarray probesets 5
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 33
    • Earliest
      J:53422 He W, et al., RGS9, a GTPase accelerator for phototransduction. Neuron. 1998 Jan;20(1):95-102
    • Latest
      J:264337 Song C, et al., Selective Role of RGS9-2 in Regulating Retrograde Synaptic Signaling of Indirect Pathway Medium Spiny Neurons in Dorsal Striatum. J Neurosci. 2018 Aug 8;38(32):7120-7131

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory