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Rgs9
Gene Detail
 Symbol
Name
ID
Rgs9
regulator of G-protein signaling 9
MGI:1338824
Synonyms RGS9-1, Rgs9-2
Feature Type protein coding gene
Genetic Map
Chromosome 11
71.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:109225355-109298129 bp, - strand
From VEGA annotation of GRCm38

  72775 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2845  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS7 type
Gene Tree: Rgs9

Human
homologs
Human Homolog RGS9, regulator of G-protein signaling 9
NCBI Gene ID 8787
neXtProt AC  NX_O75916
Human Synonyms  PERRS, RGS9L
Human Chr (Location)  17q24; chr17:65137338-65227703 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RGS9
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a targeted null mutation are viable and fertile; however, relative to wild-type, homozygous null photoreceptors display abnormally retarded recovery of their light responses, and slowed rates of GTP hydrolysis by transducin.
 
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process dopamine receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component cytoplasm, heterotrimeric G-protein complex, ...
Function GTPase activator activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (51)    Tissues (32)    Images (20)
Theiler Stages: 19, 23, 24, 28
Assay TypeResults
RNA in situ 51
cDNA source data(54)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(56) cDNA(56)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000003137 (Evidence)
Ensembl Gene ModelENSMUSG00000020599 (Evidence)
Entrez Gene19739 (Evidence)
UniGene38548
DFCITC1582988, TC1595411, TC1605384, TC1614307
DoTSDT.101341441, DT.60100966, DT.87057265, DT.97333344, DT.99716420
NIA Mouse Gene IndexU033569
PDB2PBI
Consensus CDS ProjectCCDS25576.1, CCDS48969.1
International Mouse Knockout Project StatusRgs9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003137 VEGA Gene Model | MGI Sequence Detail 72775 C57BL/6J ±  kb
transcript OTTMUST00000006459 VEGA | MGI Sequence Detail 2434 Not Applicable 
polypeptide OTTMUSP00000003041 VEGA | MGI Sequence Detail 675 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(10) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(364 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000591 DEP domain
InterPro IPR015898 G-protein gamma-like domain
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000013965 regulator of G-protein signaling 9
References (Earliest) J:53422 He W, et al., RGS9, a GTPase accelerator for phototransduction. Neuron. 1998 Jan;20(1):95-102
(Latest) J:208675 Wang N, et al., Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease. Nat Med. 2014 May;20(5):536-41
All references(63)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory