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Rgs9 Gene Detail
Summary
  • Symbol
    Rgs9
  • Name
    regulator of G-protein signaling 9
  • Synonyms
    RGS9-1, Rgs9-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338824
    NCBI Gene: 19739
  • Gene Overview
    MyGene.info: RGS9
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:109225355-109298129 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      72775 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 71.86 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    RGS9, regulator of G protein signaling 9
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RGS9, regulator of G protein signaling 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PERRS, RGS9L
  • Links
    NCBI Gene ID: 8787
    neXtProt AC: NX_O75916
    UniProt: O75916

  • Chr Location
    17q24.1; chr17:65137338-65227703 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human RGS9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    18 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable and fertile; however, relative to wild-type, homozygous null photoreceptors display abnormally retarded recovery of their light responses, and slowed rates of GTP hydrolysis by transducin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000003137 VEGA Gene Model | MGI Sequence Detail 72775 C57BL/6J ±  kb
    transcript OTTMUST00000006459 VEGA | MGI Sequence Detail 2434 Not Applicable  
    polypeptide OTTMUSP00000003041 VEGA | MGI Sequence Detail 675 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      356 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 57

      Microarray probesets 5
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 31
    • Earliest
      J:53422 He W, et al., RGS9, a GTPase accelerator for phototransduction. Neuron. 1998 Jan;20(1):95-102
    • Latest
      J:257433 Davis MI, et al., The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra. PLoS One. 2018;13(2):e0191436

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory