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Bpnt1 Gene Detail
Summary
  • Symbol
    Bpnt1
  • Name
    bisphosphate 3'-nucleotidase 1
  • Synonyms
    BPntase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338800
    NCBI Gene: 23827
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:185332149-185357777 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25629 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 89.49 cM, cytoband H4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BPNT1, 3'(2'), 5'-bisphosphate nucleotidase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BPNT1, 3'(2'), 5'-bisphosphate nucleotidase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL20, PIP
  • Links
    NCBI Gene ID: 10380
    neXtProt AC: NX_O95861
    UniProt: O95861

  • Chr Location
    1q41; chr1:220057482-220089916 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele develop severe liver pathologies, including hypoproteinemia, abnormal hepatocellular morphology and damage, and in severe cases, whole body edema and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021435 VEGA Gene Model | MGI Sequence Detail 25629 C57BL/6J ±  kb
    transcript OTTMUST00000147309 VEGA | MGI Sequence Detail 1226 Not Applicable  
    polypeptide OTTMUSP00000076669 VEGA | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      448 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • EC
    • InterPro Domains
      IPR020550 Inositol monophosphatase, conserved site
      IPR000760 Inositol monophosphatase-like
      IPR020583 Inositol monophosphatase, metal-binding site
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 64

      Microarray probesets 4
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:54522 Spiegelberg BD, et al., Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. J Biol Chem. 1999 May 7;274(19):13619-28
    • Latest
      J:259846 Hudson BH, et al., Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3000-3005

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory