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Bpnt1 Gene Detail
Summary
  • Symbol
    Bpnt1
  • Name
    bisphosphate 3'-nucleotidase 1
  • Synonyms
    BPntase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338800
    NCBI Gene: 23827
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:185332149-185357777 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 89.49 cM, cytoband H4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    448 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338800
protein coding gene Chr1:185329524-185357777 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016915
protein coding gene Chr1:192053674-192087984 (+)
A/J MGP_AJ_G0016894
protein coding gene Chr1:184206904-184233302 (+)
AKR/J MGP_AKRJ_G0016859
protein coding gene Chr1:189626825-189652605 (+)
BALB/cJ MGP_BALBcJ_G0016852
protein coding gene Chr1:184846807-184875061 (+)
C3H/HeJ MGP_C3HHeJ_G0016676
protein coding gene Chr1:190500887-190531742 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017315
protein coding gene Chr1:198190434-198217932 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015022
protein coding gene Chr1:175192094-175218291 (+)
CAST/EiJ MGP_CASTEiJ_G0016259
protein coding gene Chr1:189928368-189957502 (+)
CBA/J MGP_CBAJ_G0016650
protein coding gene Chr1:205586203-205614386 (+)
DBA/2J MGP_DBA2J_G0016756
protein coding gene Chr1:182966901-182993128 (+)
FVB/NJ MGP_FVBNJ_G0016752
protein coding gene Chr1:181063308-181093263 (+)
LP/J MGP_LPJ_G0016831
protein coding gene Chr1:193210697-193237713 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016784
protein coding gene Chr1:212457499-212490014 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017352
protein coding gene Chr1:189509488-189535096 (+)
PWK/PhJ MGP_PWKPhJ_G0016046
protein coding gene Chr1:182175219-182201285 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015822
protein coding gene Chr1:188461011-188487716 (+)
WSB/EiJ MGP_WSBEiJ_G0016321
protein coding gene Chr1:189673646-189699782 (+)



Homology
more
  • Human Ortholog
    BPNT1, 3'(2'), 5'-bisphosphate nucleotidase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BPNT1, 3'(2'), 5'-bisphosphate nucleotidase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HEL20, PIP
  • Links
    NCBI Gene ID: 10380
    neXtProt AC: NX_O95861
    UniProt: O95861

  • Chr Location
    1q41; chr1:220057482-220089916 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele develop severe liver pathologies, including hypoproteinemia, abnormal hepatocellular morphology and damage, and in severe cases, whole body edema and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026617 Ensembl Gene Model | MGI Sequence Detail 25629 C57BL/6J ±  kb
    transcript ENSMUST00000210277 Ensembl | MGI Sequence Detail 1226 Not Applicable  
    polypeptide ENSMUSP00000147674 Ensembl | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • EC
    • InterPro Domains
      IPR020550 Inositol monophosphatase, conserved site
      IPR000760 Inositol monophosphatase-like
      IPR020583 Inositol monophosphatase, metal-binding site
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 65

      Microarray probesets 4
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:54522 Spiegelberg BD, et al., Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. J Biol Chem. 1999 May 7;274(19):13619-28
    • Latest
      J:259846 Hudson BH, et al., Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3000-3005

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory