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Gtf2h4
Gene Detail
 Symbol
Name
ID
Gtf2h4
general transcription factor II H, polypeptide 4
MGI:1338799
Synonyms p52
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:35667730-35673739 bp, - strand
From VEGA annotation of GRCm38

  6010 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7090  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: TFIIH basal transcription factor complex p52 subunit
Gene Tree: Gtf2h4

Human
homologs
Human Homolog GTF2H4, general transcription factor IIH, polypeptide 4, 52kDa
NCBI Gene ID 2968
neXtProt AC  NX_Q92759
Human Synonyms  P52, TFB2, TFIIH
Human Chr (Location)  6p21.3; chr6:30908200-30914103 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Genomic Mutations involving Gtf2h4 (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Gtf2h4 interacts with 174 markers (Mir7-1, Mir7b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process ATP catabolic process, cellular response to DNA damage stimulus, ...
Component core TFIIH complex, holo TFIIH complex, ...
Function ATP-dependent DNA helicase activity, DNA-dependent ATPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (122)    Tissues (122)    Images (2)
Theiler Stages: 17, 21, 22, 23
Assay TypeResults
RNA in situ 122
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(14)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000034602 (Evidence)
Ensembl Gene ModelENSMUSG00000001524 (Evidence)
Entrez Gene14885 (Evidence)
DFCITC1575961, TC1604340, TC1733240
DoTSDT.101703244, DT.101720756, DT.110558171, DT.491946
NIA Mouse Gene IndexU037754
Consensus CDS ProjectCCDS28702.1
International Mouse Knockout Project StatusGtf2h4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034602 VEGA Gene Model | MGI Sequence Detail 6010 C57BL/6J ±  kb
transcript OTTMUST00000087787 VEGA | MGI Sequence Detail 1679 Not Applicable 
polypeptide OTTMUSP00000047801 VEGA | MGI Sequence Detail 463 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(12) UniProt(7)
Polymorphisms SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004598 Transcription factor TFIIH subunit p52/Tfb2
Protein Ontology PR:000008320 general transcription factor IIH subunit 4
References (Earliest) J:55120 Lanning D, et al., The mouse p52 subunit of the transcription/DNA repair factor TFIIH is located in the class III region of the H2 complex: cloning and sequence polymorphism. Immunogenetics. 1999 Jun;49(6):498-504
(Latest) J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000
All references(33)
Other
accession IDs
MGI:2147074

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory