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Gtf2h4 Gene Detail
Summary
  • Symbol
    Gtf2h4
  • Name
    general transcription factor II H, polypeptide 4
  • Synonyms
    p52
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338799
    NCBI Gene: 14885
  • Gene Overview
    MyGene.info: GTF2H4
Location & Maps
more
  • Sequence Map
    Chr17:35667730-35673739 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6010 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.70 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    GTF2H4, general transcription factor IIH subunit 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GTF2H4, general transcription factor IIH subunit 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    P52, TFB2, TFIIH
  • Links
    NCBI Gene ID: 2968
    neXtProt AC: NX_Q92759

  • Chr Location
    6p21.3; chr6:30908200-30914103 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
  • All Mutations and Alleles
    8
  • Gene trapped
    5
  • Targeted
    3
  • Genomic Mutations
    1 involving Gtf2h4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034602 VEGA Gene Model | MGI Sequence Detail 6010 C57BL/6J ±  kb
transcript OTTMUST00000087787 VEGA | MGI Sequence Detail 1679 Not Applicable  
polypeptide OTTMUSP00000047801 VEGA | MGI Sequence Detail 463 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000008320 general transcription factor IIH subunit 4
  • InterPro Domains
    IPR004598 Transcription factor TFIIH subunit p52/Tfb2
Molecular
Reagents
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  • All nucleic 16
    Genomic 2
    cDNA 14

    Microarray probesets 5
Other
Accession IDs
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MGI:2147074
References
more
  • Summaries
    All 30
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:55120 Lanning D, et al., The mouse p52 subunit of the transcription/DNA repair factor TFIIH is located in the class III region of the H2 complex: cloning and sequence polymorphism. Immunogenetics. 1999 Jun;49(6):498-504
  • Latest
    J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory