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Gtf2h4 Gene Detail
Summary
  • Symbol
    Gtf2h4
  • Name
    general transcription factor II H, polypeptide 4
  • Synonyms
    p52
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338799
    NCBI Gene: 14885
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35978624-35984607 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338799
 protein coding gene Chr17:35978622-35984631 (-)
129S1/SvImJ ENSMUSG00200049694
 protein coding gene Chr17:31609191-31615207 (-)
A/J ENSMUSG00195044808
 protein coding gene Chr17:32672301-32678324 (-)
AKR/J ENSMUSG00220038527
 protein coding gene Chr17:31472720-31478736 (-)
BALB/cJ ENSMUSG00180031868
 protein coding gene Chr17:32042085-32048107 (-)
C3H/HeJ ENSMUSG00175037695
 protein coding gene Chr17:31358531-31364547 (-)
C57BL/6NJ ENSMUSG00215052396
 protein coding gene Chr17:31429129-31435138 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021530
 protein coding gene Chr17:32444500-32450465 (-)
CAST/EiJ ENSTCUG00005039579
 protein coding gene Chr17:32494826-32501047 (-)
CBA/J ENSMUSG00210049088
 protein coding gene Chr17:31180606-31186622 (-)
DBA/2J ENSMUSG00185043240
 protein coding gene Chr17:34061265-34067287 (-)
FVB/NJ ENSMUSG00205053279
 protein coding gene Chr17:31722710-31728724 (-)
JF1/MsJ ENSUMUG00000015038
 protein coding gene Chr17:33002369-33008379 (-)
LP/J ENSMUSG00230054476
 protein coding gene Chr17:35097884-35103900 (-)
NOD/ShiLtJ ENSMUSG00190040567
 protein coding gene Chr17:31341865-31347880 (-)
NZO/HlLtJ ENSMUSG00225051209
 protein coding gene Chr17:37174602-37180618 (-)
PWK/PhJ ENSLUMG00010036021
 protein coding gene Chr17:30976506-30982522 (-)
SPRET/EiJ ENSMSPG00010049330
 protein coding gene Chr17:32185321-32191333 (-)
WSB/EiJ ENSIUOG00005051291
 protein coding gene Chr17:32164119-32170136 (-)



Homology
more
  • Human Ortholog
    GTF2H4, general transcription factor IIH subunit 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GTF2H4, general transcription factor IIH subunit 4
  • Synonyms
    P52, TFB2, TFIIH, XPJ
  • Links
    NCBI Gene ID: 2968
    UniProt: Q92759

  • Chr Location
    6p21.33; chr6:30907522-30914119 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    123
  • cDNA Data
    13
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14885 NCBI Gene Model | MGI Sequence Detail 5984 C57BL/6J ±  kb
transcript NM_001413326 RefSeq | MGI Sequence Detail 1694 C57BL/6  
polypeptide O70422 UniProt | EBI | MGI Sequence Detail 463 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000008320 general transcription factor IIH subunit 4
    (term hierarchy)
  • InterPro Domains
    IPR040662 Transcription factor Tfb2, C-terminal domain
    IPR004598 Transcription factor TFIIH subunit p52/Tfb2
Molecular
Reagents
less
  • All nucleic 17
    Genomic 2
    cDNA 15

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147074
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 5
  • Earliest
    J:55120 Lanning D, et al., The mouse p52 subunit of the transcription/DNA repair factor TFIIH is located in the class III region of the H2 complex: cloning and sequence polymorphism. Immunogenetics. 1999 Jun;49(6):498-504
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory