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Gtf2h4 Gene Detail
Summary
  • Symbol
    Gtf2h4
  • Name
    general transcription factor II H, polypeptide 4
  • Synonyms
    p52
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338799
    NCBI Gene: 14885
  • Gene Overview
    MyGene.info: GTF2H4
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35667730-35673739 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338799
protein coding gene Chr17:35667728-35673750 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023650
protein coding gene Chr17:35852414-35858423 (-)
A/J MGP_AJ_G0023605
protein coding gene Chr17:34746373-34752463 (-)
AKR/J MGP_AKRJ_G0023575
protein coding gene Chr17:35173825-35179841 (-)
BALB/cJ MGP_BALBcJ_G0023610
protein coding gene Chr17:34885734-34891746 (-)
C3H/HeJ MGP_C3HHeJ_G0023376
protein coding gene Chr17:35633417-35639433 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024052
protein coding gene Chr17:37322070-37328079 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021530
protein coding gene Chr17:32444500-32450465 (-)
CAST/EiJ MGP_CASTEiJ_G0022867
protein coding gene Chr17:35735084-35741135 (-)
CBA/J MGP_CBAJ_G0023354
protein coding gene Chr17:38888631-38894647 (-)
DBA/2J MGP_DBA2J_G0023478
protein coding gene Chr17:34057674-34063696 (-)
FVB/NJ MGP_FVBNJ_G0023449
protein coding gene Chr17:33851242-33857257 (-)
LP/J MGP_LPJ_G0023558
protein coding gene Chr17:36234841-36240857 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023470
protein coding gene Chr17:37665373-37671387 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024095
protein coding gene Chr17:35486400-35492416 (-)
PWK/PhJ MGP_PWKPhJ_G0022618
protein coding gene Chr17:32911101-32917153 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022437
protein coding gene Chr17:33521538-33527549 (-)
WSB/EiJ MGP_WSBEiJ_G0022933
protein coding gene Chr17:35631606-35637623 (-)



Homology
more
  • Human Ortholog
    GTF2H4, general transcription factor IIH subunit 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GTF2H4, general transcription factor IIH subunit 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    P52, TFB2, TFIIH
  • Links
    NCBI Gene ID: 2968
    neXtProt AC: NX_Q92759
    UniProt: Q92759

  • Chr Location
    6p21.33; chr6:30908200-30914103 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001524 Ensembl Gene Model | MGI Sequence Detail 6010 C57BL/6J ±  kb
transcript ENSMUST00000001565 Ensembl | MGI Sequence Detail 1679 Not Applicable  
polypeptide ENSMUSP00000001565 Ensembl | MGI Sequence Detail 463 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 2
    cDNA 15

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147074
References
more
  • Summaries
    All 32
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:55120 Lanning D, et al., The mouse p52 subunit of the transcription/DNA repair factor TFIIH is located in the class III region of the H2 complex: cloning and sequence polymorphism. Immunogenetics. 1999 Jun;49(6):498-504
  • Latest
    J:190754 Ermakova O, et al., Construction and phenotypic analysis of mice carrying a duplication of the major histocompatibility class I (MHC-I) locus. Mamm Genome. 2012 Aug;23(7-8):443-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory