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Sec22b Gene Detail
Summary
  • Symbol
    Sec22b
  • Name
    SEC22 homolog B, vesicle trafficking protein
  • Synonyms
    4930564D15Rik, ERS-24, Sec22l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338759
    NCBI Gene: 20333
  • Gene Overview
    MyGene.info: SEC22B
Location & Maps
more
  • Sequence Map
    Chr3:97901190-97923276 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22087 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SEC22B, SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEC22B, SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ERS-24, SEC22L1
  • Links
    NCBI Gene ID: 9554
    neXtProt AC: NX_O75396

  • Chr Location
    1q21.1; chr1:120155942-120176521 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Sec22b
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028867 VEGA Gene Model | MGI Sequence Detail 22087 C57BL/6J ±  kb
transcript OTTMUST00000071496 VEGA | MGI Sequence Detail 2810 Not Applicable  
polypeptide OTTMUSP00000036640 VEGA | MGI Sequence Detail 215 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    151 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 6
Other
Accession IDs
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MGI:1922615, MGI:2139737, MGI:2140084, MGI:3035211
References
more
  • Summaries
    All 37
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:46012 Hay JC, et al., Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell. 1997 Apr 4;89(1):149-58
  • Latest
    J:218865 Petkovic M, et al., The SNARE Sec22b has a non-fusogenic function in plasma membrane expansion. Nat Cell Biol. 2014 May;16(5):434-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory