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Sec22b Gene Detail
Summary
  • Symbol
    Sec22b
  • Name
    SEC22 homolog B, vesicle trafficking protein
  • Synonyms
    4930564D15Rik, ERS-24, Sec22l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338759
    NCBI Gene: 20333
  • Gene Overview
    MyGene.info: SEC22B
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:97901227-97922318 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 42.35 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338759
protein coding gene Chr3:97901190-97923276 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027646
protein coding gene Chr3:98873490-98897029 (+)
A/J MGP_AJ_G0027608
protein coding gene Chr3:95703748-95725835 (+)
AKR/J MGP_AKRJ_G0027575
protein coding gene Chr3:97997084-98019164 (+)
BALB/cJ MGP_BALBcJ_G0027618
protein coding gene Chr3:95507382-95529463 (+)
C3H/HeJ MGP_C3HHeJ_G0027350
protein coding gene Chr3:98267764-98289854 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028064
protein coding gene Chr3:102546848-102568922 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025406
protein coding gene Chr3:91961941-91984019 (+)
CAST/EiJ MGP_CASTEiJ_G0026805
protein coding gene Chr3:97564450-97586646 (+)
CBA/J MGP_CBAJ_G0027325
protein coding gene Chr3:106200239-106222325 (+)
DBA/2J MGP_DBA2J_G0027468
protein coding gene Chr3:95016033-95038866 (+)
FVB/NJ MGP_FVBNJ_G0027437
protein coding gene Chr3:93009126-93031188 (+)
LP/J MGP_LPJ_G0027573
protein coding gene Chr3:100131380-100154385 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027463
protein coding gene Chr3:112282186-112304315 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028118
protein coding gene Chr3:97622195-97644271 (+)
PWK/PhJ MGP_PWKPhJ_G0026530
protein coding gene Chr3:94905313-94927598 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026352
protein coding gene Chr3:95901533-95923589 (+)
WSB/EiJ MGP_WSBEiJ_G0026883
protein coding gene Chr3:98061519-98083606 (+)



Homology
more
  • Human Ortholog
    SEC22B, SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEC22B, SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ERS-24, SEC22L1
  • Links
    NCBI Gene ID: 9554
    neXtProt AC: NX_O75396
    UniProt: O75396

  • Chr Location
    1p12; chr1:120152520-120176534 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout has no effect on the development or function of lymphoid cells, nor on the process of antigen cross-presentation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20333 NCBI Gene Model | MGI Sequence Detail 21092 C57BL/6J ±  kb
transcript NM_011342 RefSeq | MGI Sequence Detail 1815 C57BL/6  
polypeptide O08547 UniProt | EBI | MGI Sequence Detail 215 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 6
Other
Accession IDs
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MGI:1922615, MGI:2139737, MGI:2140084, MGI:3035211
References
more
  • Summaries
    All 44
    Diseases 1
    Gene Ontology 10
    Phenotypes 10
  • Earliest
    J:46012 Hay JC, et al., Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell. 1997 Apr 4;89(1):149-58
  • Latest
    J:255769 Wu SJ, et al., A Critical Analysis of the Role of SNARE Protein SEC22B in Antigen Cross-Presentation. Cell Rep. 2017 Jun 27;19(13):2645-2656

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory