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Theg Gene Detail
Summary
  • Symbol
    Theg
  • Name
    testicular haploid expressed gene
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338756
    NCBI Gene: 21830
Location & Maps
more
  • Sequence Map
    Chr10:79576379-79587331 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10953 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband B5-C1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    THEG, theg spermatid protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    THEG, theg spermatid protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT56, THEG1
  • Links
    NCBI Gene ID: 51298
    neXtProt AC: NX_Q9P2T0

  • Chr Location
    19p13.3; chr19:362057-376703 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    1 involving Theg
  • Incidental Mutations
Males homozygotes for a transgenic insertional mutation are sterile due to a block in spermiogenesis. Testis weights are reduced, and mutants exhibit multiple abnormalities in elongated spermatids in the seminiferous tubule lumen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034744 VEGA Gene Model | MGI Sequence Detail 10953 C57BL/6J ±  kb
transcript OTTMUST00000088301 VEGA | MGI Sequence Detail 1444 Not Applicable  
polypeptide OTTMUSP00000048106 VEGA | MGI Sequence Detail 375 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    31 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016306 testicular haploid expressed gene protein
  • InterPro Domains
    IPR006623 Testicular haploid expressed repeat
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 3
References
more
  • Summaries
    All 24
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:55117 Nayernia K, et al., A novel testicular haploid expressed gene (THEG) involved in mouse spermatid-sertoli cell interaction. Biol Reprod. 1999 Jun;60(6):1488-95
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory