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Defb2
Gene Detail
Symbol

Name
ID
Defb2
defensin beta 2
MGI:1338754
Feature Type
protein coding gene
Genetic Map
Chromosome 8
10.45 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:21839926-21843482 bp, + strand
From VEGA annotation of GRCm38

  3557 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: beta-defensin
Gene Tree: Defb2
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Interactions
Defb2 interacts with 12 markers (Mir215, Mir218-1, Mir325, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process defense response, defense response to bacterium
Component extracellular region
External Resources: FuncBase
Expression
cDNA source data(3)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(3) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020785 (Evidence)
Ensembl Gene ModelENSMUSG00000006570 (Evidence)
Entrez Gene13215 (Evidence)
DFCITC1593185
NIA Mouse Gene IndexU009148
Consensus CDS ProjectCCDS40284.1
International Mouse Knockout Project StatusDefb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020785 VEGA Gene Model | MGI Sequence Detail 3557 C57BL/6J ±  kb
transcript OTTMUST00000049141 VEGA | MGI Sequence Detail 305 Not Applicable 
polypeptide OTTMUSP00000022725 VEGA | MGI Sequence Detail 71 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(9 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001855 Beta defensin type
Protein Ontology PR:000025893 beta-defensin 2
References
(Earliest) J:52008 Morrison GM, et al., A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide. FEBS Lett. 1999 Jan 8;442(1):112-6
(Latest) J:157484 Wu M, et al., Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis. J Immunol. 2009 Dec 15;183(12):8054-60
All references(25)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory