About   Help   FAQ
Defb2 Gene Detail
Summary
  • Symbol
    Defb2
  • Name
    defensin beta 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338754
    NCBI Gene: 13215
Location & Maps
more
  • Sequence Map
    Chr8:21839926-21843482 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3557 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 10.45 cM, cytoband A4
  • Mapping Data
    4 experiments
Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Genomic Mutations
    1 involving Defb2
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020785 VEGA Gene Model | MGI Sequence Detail 3557 C57BL/6J ±  kb
transcript OTTMUST00000049141 VEGA | MGI Sequence Detail 305 Not Applicable  
polypeptide OTTMUSP00000022725 VEGA | MGI Sequence Detail 71 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    9 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 3
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 22
    Gene Ontology 3
    Phenotypes 2
  • Earliest
    J:52008 Morrison GM, et al., A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide. FEBS Lett. 1999 Jan 8;442(1):112-6
  • Latest
    J:157484 Wu M, et al., Beta-defensins 2 and 3 together promote resistance to Pseudomonas aeruginosa keratitis. J Immunol. 2009 Dec 15;183(12):8054-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory