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Gnb1l Gene Detail
Summary
  • Symbol
    Gnb1l
  • Name
    guanine nucleotide binding protein (G protein), beta polypeptide 1-like
  • Synonyms
    ESTM55, Me49f07, Wdr14, Wdvcf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338057
    NCBI Gene: 13972
  • Gene Overview
    MyGene.info: GNB1L
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:18498823-18566679 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67857 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.46 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    GNB1L, G protein subunit beta 1 like
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GNB1L, G protein subunit beta 1 like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DGCRK3, FKSG1, GY2, WDR14, WDVCF
  • Links
    NCBI Gene ID: 54584
    neXtProt AC: NX_Q9BYB4
    UniProt: Q9BYB4

  • Chr Location
    22q11.21; chr22:19788411-19854939 (-)  GRCh38.p7

Human Diseases
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  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a gene trapped allele exhibit significantly reduced prepulse inhibition. Homozygotes die during early gestation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021511 VEGA Gene Model | MGI Sequence Detail 67857 C57BL/6J ±  kb
transcript OTTMUST00000050990 VEGA | MGI Sequence Detail 3549 Not Applicable  
polypeptide OTTMUSP00000023936 VEGA | MGI Sequence Detail 326 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    127 from dbSNP Build 142
Protein
Information
less
  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000008096 guanine nucleotide-binding protein subunit beta-like protein 1
  • InterPro Domains
    IPR020472 G-protein beta WD-40 repeat
    IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
    IPR011042 Six-bladed beta-propeller, TolB-like
    IPR001680 WD40 repeat
    IPR019775 WD40 repeat, conserved site
    IPR017986 WD40-repeat-containing domain
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Molecular
Reagents
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  • All nucleic 25
    Genomic 10
    cDNA 12
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1927906
References
more
  • Summaries
    All 81
    Developmental Gene Expression 9
    Diseases 5
    Gene Ontology 2
    Phenotypes 53
  • Earliest
    J:54501 Lund J, et al., Sequence-ready physical map of the mouse chromosome 16 region with conserved synteny to the human velocardiofacial syndrome region on 22q11.2. Mamm Genome. 1999 May;10(5):438-43
  • Latest
    J:242227 Antoine MW, et al., The Severity of Vestibular Dysfunction in Deafness as a Determinant of Comorbid Hyperactivity or Anxiety. J Neurosci. 2017 May 17;37(20):5144-5154

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory