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Klf5 Gene Detail
Summary
  • Symbol
    Klf5
  • Name
    Kruppel-like factor 5
  • Synonyms
    4930520J07Rik, Bteb2, CKLF, IKLF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338056
    NCBI Gene: 12224
  • Gene Overview
    MyGene.info: KLF5
Location & Maps
more
  • Sequence Map
    Chr14:99298691-99313405 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14715 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 49.43 cM, cytoband E2.1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    KLF5, Kruppel like factor 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KLF5, Kruppel like factor 5
    Orthology source: HomoloGene
  • Synonyms
    BTEB2, CKLF, IKLF
  • Links
    NCBI Gene ID: 688
    neXtProt AC: NX_Q13887

  • Chr Location
    13q22.1; chr13:73054976-73077542 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 37520
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: KLF5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    89 phenotypes from 7 alleles in 10 genetic backgrounds
    6 phenotypes from multigenic genotypes
    6 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    37
  • Chemically induced (other)
    1
  • Gene trapped
    28
  • Targeted
    8
  • Genomic Mutations
    1 involving Klf5
  • Incidental Mutations
Homozygous null mice die during gestation, while heterozygotes exhibit abnormal cardiovascular remodeling after external stress. Mice homozygous for a floxed allele activated in the prostate exhibit increased cell proliferation and hyperplasia in the prostate without neoplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005148 Ensembl Gene Model | MGI Sequence Detail 14715 C57BL/6J ±  kb
transcript ENSMUST00000005279 Ensembl | MGI Sequence Detail 1721 Not Applicable  
polypeptide ENSMUSP00000005279 Ensembl | MGI Sequence Detail 446 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    127 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009365 krueppel-like factor 5
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 21
    cDNA 19
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:1922343
References
more
  • Summaries
    All 82
    Developmental Gene Expression 29
    Gene Ontology 10
    Phenotypes 30
  • Earliest
    J:53826 Conkright MD, et al., A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells. Nucleic Acids Res. 1999 Mar 1;27(5):1263-70
  • Latest
    J:230892 Sun X, et al., Uterine inactivation of muscle segment homeobox (Msx) genes alters epithelial cell junction proteins during embryo implantation. FASEB J. 2016 Apr;30(4):1425-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory