About   Help   FAQ
Klf5 Gene Detail
Summary
  • Symbol
    Klf5
  • Name
    Kruppel-like factor 5
  • Synonyms
    4930520J07Rik, Bteb2, CKLF, IKLF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338056
    NCBI Gene: 12224
  • Gene Overview
    MyGene.info: KLF5
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:99298691-99313412 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14722 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 49.43 cM, cytoband E2.1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    KLF5, Kruppel like factor 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KLF5, Kruppel like factor 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BTEB2, CKLF, IKLF
  • Links
    NCBI Gene ID: 688
    neXtProt AC: NX_Q13887
    UniProt: Q13887

  • Chr Location
    13q22.1; chr13:73054976-73077542 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37520
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KLF5
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    89 phenotypes from 7 alleles in 10 genetic backgrounds
    6 phenotypes from multigenic genotypes
    6 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die during gestation, while heterozygotes exhibit abnormal cardiovascular remodeling after external stress. Mice homozygous for a floxed allele activated in the prostate exhibit increased cell proliferation and hyperplasia in the prostate without neoplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12224 NCBI Gene Model | MGI Sequence Detail 14722 C57BL/6J ±  kb
    transcript NM_009769 RefSeq | MGI Sequence Detail 1728 C57BL/6  
    polypeptide Q9Z0Z7 UniProt | EBI | MGI Sequence Detail 446 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      127 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 22
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1922343
    References
    more
    • Summaries
      All 106
      Developmental Gene Expression 34
      Gene Ontology 12
      Phenotypes 34
    • Earliest
      J:51610 Imhof A, et al., Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/ egr-related zinc finger repressor. Mol Cell Biol. 1999 Jan;19(1):194-204
    • Latest
      J:254799 Fujiu K, et al., A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation. Nat Med. 2017 May;23(5):611-622

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory