About   Help   FAQ
Klf5
Gene Detail
Symbol

Name
ID
Klf5
Kruppel-like factor 5
MGI:1338056
Synonyms
4930520J07Rik, Bteb2, CKLF, IKLF
Feature Type
protein coding gene
Genetic Map
Chromosome 14
49.43 cM, cytoband E2.1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:99298691-99313405 bp, + strand
From Ensembl annotation of GRCm38

  14715 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37520  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Klf5

Human
homologs
Human Homolog KLF5, Kruppel-like factor 5 (intestinal)
NCBI Gene ID 688
neXtProt AC  NX_Q13887
Human Synonyms  BTEB2, CKLF, IKLF
Human Chr (Location)  13q22.1; chr13:73054976-73077542 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(28) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die during gestation, while heterozygotes exhibit abnormal cardiovascular remodeling after external stress. Mice homozygous for a floxed allele activated in the prostate exhibit increased cell proliferation and hyperplasia in the prostate without neoplasia.
 
Phenotype Images(4)
Interactions
Klf5 interacts with 13 markers (Mir124a-1, Mir124a-2, Mir124a-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process angiogenesis, intestinal epithelial cell development, ...
Component cytoplasm, Golgi apparatus, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (141)    Tissues (50)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 97
RT-PCR 44
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(19) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000005148 (Evidence)
Entrez Gene12224 (Evidence)
DFCITC1576263, TC1589112, TC1601335, TC1732664
DoTSDT.101201408, DT.101228089, DT.101232751, DT.534920, DT.55272441, DT.97361330
NIA Mouse Gene IndexU015915
Consensus CDS ProjectCCDS27311.1
International Mouse Knockout Project StatusKlf5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005148 Ensembl Gene Model | MGI Sequence Detail 14715 C57BL/6J ±  kb
transcript ENSMUST00000005279 Ensembl | MGI Sequence Detail 1721 Not Applicable 
polypeptide ENSMUSP00000005279 Ensembl | MGI Sequence Detail 446 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009365 krueppel-like factor 5
References
(Earliest) J:53826 Conkright MD, et al., A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells. Nucleic Acids Res. 1999 Mar 1;27(5):1263-70
(Latest) J:211557 Nakaya T, et al., KLF5 regulates the integrity and oncogenicity of intestinal stem cells. Cancer Res. 2014 May 15;74(10):2882-91
All references(78)
Other
accession IDs
MGI:1922343

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/21/2014
MGI 5.20
The Jackson Laboratory