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Itsn2 Gene Detail
Summary
  • Symbol
    Itsn2
  • Name
    intersectin 2
  • Synonyms
    Eh domain, SH3 domain regulator of endocytosis 2, Ese2, mKIAA1256, Sh3d1B, Sh3p18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338049
    NCBI Gene: 20403
  • Gene Overview
    MyGene.info: ITSN2
Location & Maps
more
  • Sequence Map
    Chr12:4592638-4713962 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      121325 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 2.09 cM, cytoband A1.1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ITSN2, intersectin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ITSN2, intersectin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRO2015, SH3D1B, SH3P18, SWA, SWAP
  • Links
    NCBI Gene ID: 50618
    neXtProt AC: NX_Q9NZM3
    UniProt: Q9NZM3

  • Chr Location
    2p23.3; chr2:24202866-24360528 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 22627
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ITSN2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal brain morphology and function and behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020640 Ensembl Gene Model | MGI Sequence Detail 121325 C57BL/6J ±  kb
transcript ENSMUST00000220311 Ensembl | MGI Sequence Detail 6080 Not Applicable  
polypeptide ENSMUSP00000151896 Ensembl | MGI Sequence Detail 1685 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    922 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 130
    cDNA 130

    Microarray probesets 9
Other
Accession IDs
less
MGI:2144799
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:53505 Sengar AS, et al., The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15. EMBO J. 1999 Mar 1;18(5):1159-71
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory