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Ctsw Gene Detail
Summary
  • Symbol
    Ctsw
  • Name
    cathepsin W
  • Synonyms
    lymphopain
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338045
    NCBI Gene: 13041
  • Gene Overview
    MyGene.info: CTSW
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5465240-5468498 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.33 cM, cytoband A
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338045
protein coding gene Chr19:5465043-5470389 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024709
protein coding gene Chr19:2434477-2437735 (-)
A/J MGP_AJ_G0024675
protein coding gene Chr19:2299885-2303142 (-)
AKR/J MGP_AKRJ_G0024648
protein coding gene Chr19:2357795-2361052 (-)
BALB/cJ MGP_BALBcJ_G0024675
protein coding gene Chr19:2293640-2296897 (-)
C3H/HeJ MGP_C3HHeJ_G0024443
protein coding gene Chr19:2367358-2370615 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025122
protein coding gene Chr19:2490069-2493327 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022552
protein coding gene Chr19:2202485-2205766 (-)
CAST/EiJ MGP_CASTEiJ_G0023915
protein coding gene Chr19:2394801-2398071 (-)
CBA/J MGP_CBAJ_G0024415
protein coding gene Chr19:2599463-2602721 (-)
DBA/2J MGP_DBA2J_G0024542
protein coding gene Chr19:2279270-2282528 (-)
FVB/NJ MGP_FVBNJ_G0024509
protein coding gene Chr19:2286041-2289298 (-)
LP/J MGP_LPJ_G0024628
protein coding gene Chr19:2413942-2417200 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024539
protein coding gene Chr19:2454133-2457390 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025170
protein coding gene Chr19:2375615-2378873 (-)
PWK/PhJ MGP_PWKPhJ_G0023661
protein coding gene Chr19:2316351-2319621 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023466
protein coding gene Chr19:2360279-2363551 (-)
WSB/EiJ MGP_WSBEiJ_G0023977
protein coding gene Chr19:2386533-2389791 (-)



Homology
more
  • Human Ortholog
    CTSW, cathepsin W
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CTSW, cathepsin W
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LYPN
  • Links
    NCBI Gene ID: 1521
    neXtProt AC: NX_P56202
    UniProt: P56202

  • Chr Location
    11q13.1; chr11:65879813-65883741 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Homozygous null mutants are fertile and healthy with normal cytotoxic lymphocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024910 Ensembl Gene Model | MGI Sequence Detail 3259 C57BL/6J ±  kb
transcript ENSMUST00000025844 Ensembl | MGI Sequence Detail 1232 Not Applicable  
polypeptide ENSMUSP00000025844 Ensembl | MGI Sequence Detail 371 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    Genomic 1
    cDNA 21

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:50847 Brown J, et al., Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase. Leukemia. 1998 Nov;12(11):1771-81
  • Latest
    J:219639 Oghumu S, et al., CXCR3 expression defines a novel subset of innate CD8+ T cells that enhance immunity against bacterial infection and cancer upon stimulation with IL-15. FASEB J. 2015 Mar;29(3):1019-28

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory