Cyp8b1
Gene Detail

Symbol Name ID

Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 MGI:1338044

Synonyms

sterol 12-alpha-hydrolase

Feature Type

protein coding gene

Genetic Map

Chromosome 9

72.73 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:121914356-121916305 bp, - strand From VEGA annotation of GRCm38   1950 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3233  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: cytochrome P450, CYP7A1 type
Gene Tree: Cyp8b1

Human homologs

Human Homolog		CYP8B1, cytochrome P450, family 8, subfamily B, polypeptide 1
NCBI Gene ID		1582
neXtProt AC		NX_Q9UNU6
Human Synonyms		CP8B, CYP12
Human Chr (Location)		3p22.1; chr3:42913684-42917633 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele lack synthsesis of cholate (a primary bile acid) and its metabolites and display an increased bile acid pool and alterations in cholesterol metabolism.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Component	endoplasmic reticulum, integral to membrane, ...
Function	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity, electron carrier activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (106)    Tissues (106)   
Theiler Stages: 10, 18, 22, 23, 25, 28

Assay Type	Results
RNA in situ	94
RT-PCR	12

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(1) cDNA(25) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000022966 (Evidence)
Ensembl Gene Model	ENSMUSG00000050445 (Evidence)
Entrez Gene	13124 (Evidence)
UniGene	20889
DFCI	TC1582953
DoTS	DT.490577
NIA Mouse Gene Index	U031456
EC	1.14.13.95
Consensus CDS Project	CCDS23641.1
International Mouse Knockout Project Status	Cyp8b1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022966	VEGA Gene Model | MGI Sequence Detail	1950	C57BL/6J
transcript	OTTMUST00000055272	VEGA | MGI Sequence Detail	1950	Not Applicable
polypeptide	OTTMUSP00000026445	VEGA | MGI Sequence Detail	500	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(15 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001128	Cytochrome P450
InterPro	IPR024204	Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
InterPro	IPR002403	Cytochrome P450, E-class, group IV
Protein Ontology	PR:000006150	cytochrome P450 8B1

References

(Earliest) J:53496 Gafvels M, et al., Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Genomics. 1999 Mar 1;56(2):184-96
(Latest) J:187177 Bochkis IM, et al., Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2. PLoS Genet. 2012 Jun;8(6):e1002770
All references(36)