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Cyp8b1
Gene Detail
Symbol

Name
ID
Cyp8b1
cytochrome P450, family 8, subfamily b, polypeptide 1
MGI:1338044
Synonyms
sterol 12-alpha-hydrolase
Feature Type
protein coding gene
Genetic Map
Chromosome 9
72.73 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:121914356-121916305 bp, - strand
From VEGA annotation of GRCm38

  1950 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3233  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 western clawed frog; 3 zebrafish

Protein SuperFamily: cytochrome P450, CYP7A1 type
Gene Tree: Cyp8b1

Human
homologs
Human Homolog CYP8B1, cytochrome P450, family 8, subfamily B, polypeptide 1
NCBI Gene ID 1582
neXtProt AC  NX_Q9UNU6
Human Synonyms  CP8B, CYP12
Human Chr (Location)  3p22.1; chr3:42872192-42876141 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele lack synthsesis of cholate (a primary bile acid) and its metabolites and display an increased bile acid pool and alterations in cholesterol metabolism.
 
Interactions
Cyp8b1 interacts with 51 markers (Mir24-1, Mir24-2, Mir34b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (106)    Tissues (106)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 12
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(25) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022966 (Evidence)
Ensembl Gene ModelENSMUSG00000050445 (Evidence)
Entrez Gene13124 (Evidence)
UniGene20889
DFCITC1582953
DoTSDT.490577
NIA Mouse Gene IndexU031456
EC1.14.13.95
Consensus CDS ProjectCCDS23641.1
International Mouse Knockout Project StatusCyp8b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022966 VEGA Gene Model | MGI Sequence Detail 1950 C57BL/6J ±  kb
transcript OTTMUST00000055272 VEGA | MGI Sequence Detail 1950 Not Applicable 
polypeptide OTTMUSP00000026445 VEGA | MGI Sequence Detail 500 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
InterPro IPR002403 Cytochrome P450, E-class, group IV
Protein Ontology PR:000006150 cytochrome P450 8B1
References
(Earliest) J:53496 Gafvels M, et al., Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Genomics. 1999 Mar 1;56(2):184-96
(Latest) J:196553 Lorbek G, et al., Cytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases. FEBS J. 2012 May;279(9):1516-33
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory