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Cyp8b1 Gene Detail
Summary
  • Symbol
    Cyp8b1
  • Name
    cytochrome P450, family 8, subfamily b, polypeptide 1
  • Synonyms
    sterol 12-alpha-hydrolase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338044
    NCBI Gene: 13124
  • Gene Overview
    MyGene.info: CYP8B1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:121914356-121916305 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 72.73 cM, cytoband F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338044
protein coding gene Chr9:121914356-121916305 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035454
protein coding gene Chr9:124881244-124883193 (-)
A/J MGP_AJ_G0035435
protein coding gene Chr9:120124296-120126245 (-)
AKR/J MGP_AKRJ_G0035368
protein coding gene Chr9:123329582-123331531 (-)
BALB/cJ MGP_BALBcJ_G0035431
protein coding gene Chr9:120035627-120037576 (-)
C3H/HeJ MGP_C3HHeJ_G0035138
protein coding gene Chr9:123783979-123785928 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035954
protein coding gene Chr9:128302631-128304580 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032836
protein coding gene Chr9:117280986-117282935 (-)
CAST/EiJ MGP_CASTEiJ_G0034443
protein coding gene Chr9:123834352-123836301 (-)
CBA/J MGP_CBAJ_G0035106
protein coding gene Chr9:133000975-133002924 (-)
DBA/2J MGP_DBA2J_G0035265
protein coding gene Chr9:119567057-119569006 (-)
FVB/NJ MGP_FVBNJ_G0035212
protein coding gene Chr9:118483983-118485932 (-)
LP/J MGP_LPJ_G0035344
protein coding gene Chr9:125217381-125219330 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035253
protein coding gene Chr9:133918085-133920034 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035973
protein coding gene Chr9:123768105-123770054 (-)
PWK/PhJ MGP_PWKPhJ_G0034147
protein coding gene Chr9:120022445-120024393 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033984
protein coding gene Chr9:123890423-123892372 (-)
WSB/EiJ MGP_WSBEiJ_G0034563
protein coding gene Chr9:123626415-123628364 (-)



Homology
more
  • Human Ortholog
    CYP8B1, cytochrome P450 family 8 subfamily B member 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    CYP8B1, cytochrome P450 family 8 subfamily B member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CP8B, CYP12
  • Links
    NCBI Gene ID: 1582
    neXtProt AC: NX_Q9UNU6
    UniProt: Q9UNU6

  • Chr Location
    3p22.1; chr3:42872192-42876141 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele lack synthsesis of cholate (a primary bile acid) and its metabolites and display an increased bile acid pool and alterations in cholesterol metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13124 NCBI Gene Model | MGI Sequence Detail 1950 C57BL/6J ±  kb
    transcript NM_010012 RefSeq | MGI Sequence Detail 1950 C57BL/6  
    polypeptide O88962 UniProt | EBI | MGI Sequence Detail 500 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 26
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:53496 Gafvels M, et al., Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Genomics. 1999 Mar 1;56(2):184-96
    • Latest
      J:261966 Patankar JV, et al., Genetic ablation of Cyp8b1 preserves host metabolic function by repressing steatohepatitis and altering gut microbiota composition. Am J Physiol Endocrinol Metab. 2018 May 1;314(5):E418-E432

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory