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Cyp8b1
Gene Detail
Symbol

Name
ID
Cyp8b1
cytochrome P450, family 8, subfamily b, polypeptide 1
MGI:1338044
Synonyms
sterol 12-alpha-hydrolase
Feature Type
protein coding gene
Genetic Map
Chromosome 9
72.73 cM, cytoband F4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:121914356-121916305 bp, - strand
From VEGA annotation of GRCm38

  1950 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3233  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 western clawed frog; 3 zebrafish

HCOP human homology predictions: CYP8B1
Protein SuperFamily: cytochrome P450, CYP7A1 type
Gene Tree: Cyp8b1

Human
homologs
CYP8B1, cytochrome P450, family 8, subfamily B, polypeptide 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1582
neXtProt AC: NX_Q9UNU6

Human Synonyms: CP8B, CYP12

Human Chr (Location): 3p22.1; chr3:42872192-42876141 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele lack synthsesis of cholate (a primary bile acid) and its metabolites and display an increased bile acid pool and alterations in cholesterol metabolism.
 
Interactions
Cyp8b1 interacts with 51 markers (Mir24-1, Mir24-2, Mir34b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (106)    Tissues (106)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 12
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100488168    NEW 
Molecular
reagents
All nucleic(27) Genomic(1) cDNA(25) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022966 (Evidence)
Ensembl Gene Model ENSMUSG00000050445 (Evidence)
Entrez Gene 13124 (Evidence)
UniGene 20889
DFCI TC1582953
DoTS DT.490577
NIA Mouse Gene Index U031456
EC 1.14.13.95
Consensus CDS Project CCDS23641.1
International Mouse Phenotyping Consortium Status Cyp8b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022966 VEGA Gene Model | MGI Sequence Detail 1950 C57BL/6J ±  kb
transcript OTTMUST00000055272 VEGA | MGI Sequence Detail 1950 Not Applicable 
polypeptide OTTMUSP00000026445 VEGA | MGI Sequence Detail 500 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
InterPro IPR002403 Cytochrome P450, E-class, group IV
Protein Ontology PR:000006150 cytochrome P450 8B1
References
(Earliest) J:53496 Gafvels M, et al., Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns. Genomics. 1999 Mar 1;56(2):184-96
(Latest) J:196553 Lorbek G, et al., Cytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases. FEBS J. 2012 May;279(9):1516-33
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory