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Pcdh10 Gene Detail
Summary
  • Symbol
    Pcdh10
  • Name
    protocadherin 10
  • Synonyms
    6430521D13Rik, 6430703F07Rik, mKIAA1400, OL-pc
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338042
    NCBI Gene: 18526
  • Gene Overview
    MyGene.info: PCDH10
Location & Maps
more
  • Sequence Map
    Chr3:45378398-45435623 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      57226 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 20.35 cM, cytoband C
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PCDH10, protocadherin 10
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PCDH10, protocadherin 10
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OL-PCDH, PCDH19
  • Links
    NCBI Gene ID: 57575
    neXtProt AC: NX_Q9P2E7

  • Chr Location
    4q28.3; chr4:133149290-133208606 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    2 involving Pcdh10
  • Incidental Mutations
Mice homozygous for a reporter allele die within several weeks of birth and exhibit decreased body size and defective striatal axon growth and thalamocortical projections in the ventral telencephalon.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050879 VEGA Gene Model | MGI Sequence Detail 57226 C57BL/6J ±  kb
transcript OTTMUST00000128956 VEGA | MGI Sequence Detail 7081 Not Applicable  
polypeptide OTTMUSP00000069338 VEGA | MGI Sequence Detail 1057 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    324 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 60
    cDNA 60

    Microarray probesets 6
Other
Accession IDs
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MGI:1923459, MGI:2444165
References
more
  • Summaries
    All 31
    Developmental Gene Expression 9
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:52412 Hirano S, et al., Expression of a novel protocadherin, OL-protocadherin, in a subset of functional systems of the developing mouse brain. J Neurosci. 1999 Feb 1;19(3):995-1005
  • Latest
    J:231010 Oishi K, et al., Identity of neocortical layer 4 neurons is specified through correct positioning into the cortex. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory