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Tfg Gene Detail
Summary
  • Symbol
    Tfg
  • Name
    Trk-fused gene
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338041
    NCBI Gene: 21787
  • Gene Overview
    MyGene.info: TFG
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:56690332-56717450 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 34.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    315 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338041
protein coding gene Chr16:56690329-56717532 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022890
protein coding gene Chr16:55823863-55852134 (-)
A/J MGP_AJ_G0022857
protein coding gene Chr16:53421058-53448173 (-)
AKR/J MGP_AKRJ_G0022829
protein coding gene Chr16:55111382-55138499 (-)
BALB/cJ MGP_BALBcJ_G0022857
protein coding gene Chr16:53525433-53552550 (-)
C3H/HeJ MGP_C3HHeJ_G0022620
protein coding gene Chr16:55303436-55330553 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023305
protein coding gene Chr16:57411303-57440615 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020816
protein coding gene Chr16:53102214-53129750 (-)
CAST/EiJ MGP_CASTEiJ_G0022147
protein coding gene Chr16:55660967-55722574 (-)
CBA/J MGP_CBAJ_G0022593
protein coding gene Chr16:59699357-59728144 (-)
DBA/2J MGP_DBA2J_G0022725
protein coding gene Chr16:53181863-53209232 (-)
FVB/NJ MGP_FVBNJ_G0022700
protein coding gene Chr16:52947319-52974546 (-)
LP/J MGP_LPJ_G0022792
protein coding gene Chr16:55640487-55667533 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022718
protein coding gene Chr16:60027439-60068442 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023320
protein coding gene Chr16:55286339-55314708 (-)
PWK/PhJ MGP_PWKPhJ_G0021886
protein coding gene Chr16:53468062-53531147 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021716
protein coding gene Chr16:54999869-55061456 (-)
WSB/EiJ MGP_WSBEiJ_G0022191
protein coding gene Chr16:55308065-55335162 (-)



Homology
more
  • Human Ortholog
    TFG, TRK-fused gene
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TFG, TRK-fused gene
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HMSNP, SPG57, TF6, TRKT3
  • Links
    NCBI Gene ID: 10342
    neXtProt AC: NX_Q92734
    UniProt: Q92734

  • Chr Location
    3q12.2; chr3:100709284-100748967 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4426
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TFG
  • Gene Tree
    Tfg
Human Diseases
more
  • Diseases
    2 with human TFG associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022757 Ensembl Gene Model | MGI Sequence Detail 27119 C57BL/6J ±  kb
transcript ENSMUST00000065515 Ensembl | MGI Sequence Detail 1945 Not Applicable  
polypeptide ENSMUSP00000067867 Ensembl | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 25

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146382
References
more
  • Summaries
    All 28
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:54190 Mencinger M, et al., Characterization of TFG in mus musculus and Caenorhabditis elegans. Biochem Biophys Res Commun. 1999 Apr 2;257(1):67-73
  • Latest
    J:264370 Sima J, et al., Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8173-8178

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory