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Tfg
Gene Detail
Symbol

Name
ID
Tfg
Trk-fused gene
MGI:1338041
Feature Type
protein coding gene
Genetic Map
Chromosome 16
34.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:56690332-56717450 bp, - strand
From VEGA annotation of GRCm38

  27119 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4426  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TFG
Gene Tree: Tfg

Human
homologs
TFG, TRK-fused gene
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10342
neXtProt AC: NX_Q92734

Human Synonyms: HMSNP, SPG57, TF6, TRKT3

Human Chr (Location): 3q12.2; chr3:100709284-100748967 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TFG

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(18) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Tfg interacts with 135 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process positive regulation of I-kappaB kinase/NF-kappaB signaling, signal transduction
Component extracellular exosome
Function identical protein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (14)    Tissues (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
Northern blot 4
cDNA source data(24)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase tfg ; ZFIN tfg    NEW 
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026667 (Evidence)
Ensembl Gene Model ENSMUSG00000022757 (Evidence)
Entrez Gene 21787 (Evidence)
DFCI TC1572104, TC1718268, TC1596502, TC1645170, TC1699338, TC1604378, TC1596819
DoTS DT.101358804, DT.492285, DT.101380206, DT.94275270
NIA Mouse Gene Index U037119
Consensus CDS Project CCDS28224.1
International Mouse Phenotyping Consortium Status Tfg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026667 VEGA Gene Model | MGI Sequence Detail 27119 C57BL/6J ±  kb
transcript OTTMUST00000065984 VEGA | MGI Sequence Detail 1945 Not Applicable 
polypeptide OTTMUSP00000032965 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(100) RefSeq(12) UniProt(9)
Polymorphisms
SNPs within 2kb(316 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000270 Phox/Bem1p
Protein Ontology PR:000016277 protein TFG
References
(Earliest) J:54190 Mencinger M, et al., Characterization of TFG in mus musculus and Caenorhabditis elegans. Biochem Biophys Res Commun. 1999 Apr 2;257(1):67-73
(Latest) J:149737 Sansom SN, et al., The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun;5(6):e1000511
All references(31)
Other
accession IDs
MGI:2146382

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory