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Tfg Gene Detail
Summary
  • Symbol
    Tfg
  • Name
    Trk-fused gene
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338041
    NCBI Gene: 21787
  • Gene Overview
    MyGene.info: TFG
Location & Maps
more
  • Sequence Map
    Chr16:56690332-56717450 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27119 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 34.22 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TFG, TRK-fused gene
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TFG, TRK-fused gene
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HMSNP, SPG57, TF6, TRKT3
  • Links
    NCBI Gene ID: 10342
    neXtProt AC: NX_Q92734

  • Chr Location
    3q12.2; chr3:100709284-100748967 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4426
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TFG
  • Gene Tree
    Tfg
Human Diseases
more
  • Diseases
    2 with human TFG associations

Human Disease Mouse Models
       Neuropathy, Hereditary Motor and Sensory, Okinawa Type; HMSNO   OMIM: 604484
Spastic Paraplegia 57, Autosomal Recessive; SPG57   OMIM: 615658
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    19
  • Gene trapped
    18
  • Targeted
    1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026667 VEGA Gene Model | MGI Sequence Detail 27119 C57BL/6J ±  kb
transcript OTTMUST00000065984 VEGA | MGI Sequence Detail 1945 Not Applicable  
polypeptide OTTMUSP00000032965 VEGA | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    315 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146382
References
more
  • Summaries
    All 27
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:54190 Mencinger M, et al., Characterization of TFG in mus musculus and Caenorhabditis elegans. Biochem Biophys Res Commun. 1999 Apr 2;257(1):67-73
  • Latest
    J:149737 Sansom SN, et al., The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun;5(6):e1000511

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory