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Tfg Gene Detail
Summary
  • Symbol
    Tfg
  • Name
    Trk-fused gene
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338041
    NCBI Gene: 21787
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:56510695-56537813 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 34.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    315 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338041
 protein coding gene Chr16:56510692-56541801 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022890
 protein coding gene Chr16:55823863-55852134 (-)
A/J MGP_AJ_G0022857
 protein coding gene Chr16:53421058-53448173 (-)
AKR/J MGP_AKRJ_G0022829
 protein coding gene Chr16:55111382-55138499 (-)
BALB/cJ MGP_BALBcJ_G0022857
 protein coding gene Chr16:53525433-53552550 (-)
C3H/HeJ MGP_C3HHeJ_G0022620
 protein coding gene Chr16:55303436-55330553 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023305
 protein coding gene Chr16:57411303-57440615 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020816
 protein coding gene Chr16:53102214-53129750 (-)
CAST/EiJ MGP_CASTEiJ_G0022147
 protein coding gene Chr16:55660967-55722574 (-)
CBA/J MGP_CBAJ_G0022593
 protein coding gene Chr16:59699357-59728144 (-)
DBA/2J MGP_DBA2J_G0022725
 protein coding gene Chr16:53181863-53209232 (-)
FVB/NJ MGP_FVBNJ_G0022700
 protein coding gene Chr16:52947319-52974546 (-)
LP/J MGP_LPJ_G0022792
 protein coding gene Chr16:55640487-55667533 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022718
 protein coding gene Chr16:60027439-60068442 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023320
 protein coding gene Chr16:55286339-55314708 (-)
PWK/PhJ MGP_PWKPhJ_G0021886
 protein coding gene Chr16:53468062-53531147 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021716
 protein coding gene Chr16:54999869-55061456 (-)
WSB/EiJ MGP_WSBEiJ_G0022191
 protein coding gene Chr16:55308065-55335162 (-)



Homology
more
  • Human Ortholog
    TFG, trafficking from ER to golgi regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TFG, trafficking from ER to golgi regulator
  • Synonyms
    HMSNP, SPG57, TF6, TRKT3
  • Links
    NCBI Gene ID: 10342
    neXtProt AC: NX_Q92734
    UniProt: Q92734

  • Chr Location
    3q12.2; chr3:100709290-100748967 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TFG associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    13
  • cDNA Data
    25
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022757 Ensembl Gene Model | MGI Sequence Detail 27119 C57BL/6J ±  kb
transcript ENSMUST00000065515 Ensembl | MGI Sequence Detail 1945 Not Applicable  
polypeptide ENSMUSP00000067867 Ensembl | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 25

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146382
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:54190 Mencinger M, et al., Characterization of TFG in mus musculus and Caenorhabditis elegans. Biochem Biophys Res Commun. 1999 Apr 2;257(1):67-73
  • Latest
    J:322546 Yamamotoya T, et al., Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases. Sci Rep. 2022 Feb 4;12(1):1966
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory