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Ovol2
Gene Detail
 Symbol
Name
ID
Ovol2
ovo-like 2 (Drosophila)
MGI:1338039
Synonyms 1810007D21Rik, M-OVO, movo2, M-OVO-A, M-OVO-B, Ovol2, Zfp339
Feature Type protein coding gene
Genetic Map
Chromosome 2
70.99 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:144305175-144332146 bp, - strand
From VEGA annotation of GRCm38

  26972 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10930  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor, Ovol1/Ovol2 types
Gene Tree: Ovol2

Human
homologs
Human Homolog OVOL2, ovo-like zinc finger 2
NCBI Gene ID 58495
neXtProt AC  NX_Q9BRP0
Human Synonyms  EUROIMAGE566589, ZNF339
Human Chr (Location)  20p11.23; chr20:18024152-18059190 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(25) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a null allele are small and die at E9.5-E10.5 with an open neural tube, impaired extraembryonic and embryonic vascularization, abnormal cardiogenesis and placental defects. Homozygotes for another null allele die by E10.5 with brain, neural crest, gut tube and heart anomalies.
 
Interactions
Ovol2 interacts with 112 markers (Mir26a-1, Mir26a-2, Mir26b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process angiogenesis, dorsal/ventral pattern formation, ...
Component nucleus
Function DNA binding, metal ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (141)    Tissues (132)    Images (3)
Theiler Stages: 2, 3, 4, 5, 21, 22, 23, 28
Assay TypeResults
RNA in situ 133
RT-PCR 8
cDNA source data(21)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(21) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000003483 (Evidence)
Ensembl Gene ModelENSMUSG00000037279 (Evidence)
Entrez Gene107586 (Evidence)
UniGene252750
DFCITC1582839, TC1593746, TC1596884, TC1742974
Consensus CDS ProjectCCDS16817.1, CCDS16818.1
International Mouse Knockout Project StatusOvol2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003483 VEGA Gene Model | MGI Sequence Detail 26972 C57BL/6J ±  kb
transcript OTTMUST00000007457 VEGA | MGI Sequence Detail 1539 Not Applicable 
polypeptide OTTMUSP00000003593 VEGA | MGI Sequence Detail 274 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(7) UniProt(2)
Polymorphisms SNPs within 2kb(302 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000012091 transcription factor Ovo-like 2
References (Earliest) J:45546 Masu Y, et al., Expression of murine novel zinc finger proteins highly homologous to Drosophila ovo gene product in testis. FEBS Lett. 1998 Jan 16;421(3):224-8
(Latest) J:211311 Watanabe K, et al., Mammary morphogenesis and regeneration require the inhibition of EMT at terminal end buds by Ovol2 transcriptional repressor. Dev Cell. 2014 Apr 14;29(1):59-74
All references(46)
Other
accession IDs
MGI:1916309

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory