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Ovol2 Gene Detail
Summary
  • Symbol
    Ovol2
  • Name
    ovo like zinc finger 2
  • Synonyms
    1810007D21Rik, M-OVO, movo2, M-OVO-A, M-OVO-B, Ovol2, Zfp339
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338039
    NCBI Gene: 107586
Location & Maps
more
  • Sequence Map
    Chr2:144305175-144332146 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26972 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 70.99 cM, cytoband H1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    OVOL2, ovo like zinc finger 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OVOL2, ovo like zinc finger 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EUROIMAGE566589, PPCD1, ZNF339
  • Links
    NCBI Gene ID: 58495
    neXtProt AC: NX_Q9BRP0

  • Chr Location
    20p11.23; chr20:18024152-18059188 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human OVOL2 associations

Human Disease Mouse Models
       Corneal Dystrophy, Posterior Polymorphous, 1; PPCD1   OMIM: 122000
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    30
  • Chemically induced (other)
    1
  • Gene trapped
    25
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Ovol2
  • Incidental Mutations
Embryos homozygous for a null allele are small and die at E9.5-E10.5 with an open neural tube, impaired extraembryonic and embryonic vascularization, abnormal cardiogenesis and placental defects. Homozygotes for another null allele die by E10.5 with brain, neural crest, gut tube and heart anomalies.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003483 VEGA Gene Model | MGI Sequence Detail 26972 C57BL/6J ±  kb
transcript OTTMUST00000007457 VEGA | MGI Sequence Detail 1539 Not Applicable  
polypeptide OTTMUSP00000003593 VEGA | MGI Sequence Detail 274 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    296 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012091 transcription factor Ovo-like 2
  • InterPro Domains
    IPR027775 C2H2- zinc finger protein family
    IPR027755 Transcription factor Ovo-like
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
less
  • All nucleic 23
    cDNA 21
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1916309
References
more
  • Summaries
    All 44
    Developmental Gene Expression 12
    Gene Ontology 10
    Phenotypes 10
  • Earliest
    J:45546 Masu Y, et al., Expression of murine novel zinc finger proteins highly homologous to Drosophila ovo gene product in testis. FEBS Lett. 1998 Jan 16;421(3):224-8
  • Latest
    J:226614 Costello I, et al., Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 2015 Oct 15;29(20):2108-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory