Itgb8
Gene Detail

Symbol Name ID

Itgb8 integrin beta 8 MGI:1338035

Synonyms

4832412O06Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 12

63.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr12:119158022-119238802 bp, - strand From VEGA annotation of GRCm38   80781 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:18567  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb8

Human homologs

Human Homolog		ITGB8, integrin, beta 8
NCBI Gene ID		3696
neXtProt AC		NX_P26012
Human Chr (Location)		7p21.1; chr7:20370725-20455382 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruption of this gene either die before E11.5 as a result of circulatory abnormalities in the placenta or die within the first for days after birth and display intracerebral hemorrhaging.

 

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	cell adhesion, ganglioside metabolic process, ...
Component	integral to membrane, membrane
Function	receptor binding

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (222)    Tissues (53)    Images (35)
Theiler Stages: 15, 17, 20, 21, 23, 28

Assay Type	Results
RNA in situ	222

cDNA source data(47)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(47) cDNA(47)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000026449 (Evidence)
Ensembl Gene Model	ENSMUSG00000025321 (Evidence)
Entrez Gene	320910 (Evidence)
UniGene	217000
DFCI	TC1589548, TC1597197, TC1602951
DoTS	DT.91281973, DT.91313358, DT.91589329
NIA Mouse Gene Index	U034470
Consensus CDS Project	CCDS36580.1
International Mouse Knockout Project Status	Itgb8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026449	VEGA Gene Model | MGI Sequence Detail	80781	C57BL/6J
transcript	OTTMUST00000065410	VEGA | MGI Sequence Detail	8403	Not Applicable
polypeptide	OTTMUSP00000032602	VEGA | MGI Sequence Detail	767	Not Applicable

All sequences(29) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(366 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR015442	Integrin beta-8 subunit
InterPro	IPR015812	Integrin beta subunit
InterPro	IPR002369	Integrin beta subunit, N-terminal
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000009144	integrin beta-8

References

(Earliest) J:47716 Nishimura SL, et al., Synaptic and glial localization of the integrin alphavbeta8 in mouse and rat brain. Brain Res. 1998 Apr 27;791(1-2):271-82
(Latest) J:194125 Shibahara K, et al., Production of gastrointestinal tumors in mice by modulating latent TGF-beta1 activation. Cancer Res. 2013 Jan 1;73(1):459-68
All references(46)

Other accession IDs

MGI:2445021