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Itgb8 Gene Detail
Summary
  • Symbol
    Itgb8
  • Name
    integrin beta 8
  • Synonyms
    4832412O06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338035
    NCBI Gene: 320910
  • Gene Overview
    MyGene.info: ITGB8
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:119158022-119238802 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      80781 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 63.48 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ITGB8, integrin subunit beta 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ITGB8, integrin subunit beta 8
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 3696
    neXtProt AC: NX_P26012
    UniProt: P26012

  • Chr Location
    7p21.1; chr7:20329819-20415759 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 2 alleles in 4 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene either die before E11.5 as a result of circulatory abnormalities in the placenta or die within the first for days after birth and display intracerebral hemorrhaging.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000026449 VEGA Gene Model | MGI Sequence Detail 80781 C57BL/6J ±  kb
    transcript OTTMUST00000065410 VEGA | MGI Sequence Detail 8403 Not Applicable  
    polypeptide OTTMUSP00000032602 VEGA | MGI Sequence Detail 767 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      486 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 48

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2445021
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 12
      Gene Ontology 3
      Phenotypes 28
    • Earliest
      J:47716 Nishimura SL, et al., Synaptic and glial localization of the integrin alphavbeta8 in mouse and rat brain. Brain Res. 1998 Apr 27;791(1-2):271-82
    • Latest
      J:254804 Zhang D, et al., D-mannose induces regulatory T cells and suppresses immunopathology. Nat Med. 2017 Sep;23(9):1036-1045

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory