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Itgb8
Gene Detail
Symbol

Name
ID
Itgb8
integrin beta 8
MGI:1338035
Synonyms
4832412O06Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 12
63.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:119158022-119238802 bp, - strand
From VEGA annotation of GRCm38

  80781 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18567  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb8

Human
homologs
Human Homolog ITGB8, integrin, beta 8
NCBI Gene ID 3696
neXtProt AC  NX_P26012
Human Chr (Location)  7p21.1; chr7:20330727-20415759 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene either die before E11.5 as a result of circulatory abnormalities in the placenta or die within the first for days after birth and display intracerebral hemorrhaging.
 
Interactions
Itgb8 interacts with 473 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cartilage development, ganglioside metabolic process, ...
Component cell surface, extracellular vesicular exosome, ...
Function extracellular matrix protein binding, receptor binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (222)    Tissues (53)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 222
cDNA source data(47)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) cDNA(47)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000026449 (Evidence)
Ensembl Gene ModelENSMUSG00000025321 (Evidence)
Entrez Gene320910 (Evidence)
UniGene217000
DFCITC1597197, TC1589548, TC1602951
DoTSDT.91313358, DT.91281973, DT.91589329
NIA Mouse Gene IndexU034470
Consensus CDS ProjectCCDS36580.1
International Mouse Knockout Project StatusItgb8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026449 VEGA Gene Model | MGI Sequence Detail 80781 C57BL/6J ±  kb
transcript OTTMUST00000065410 VEGA | MGI Sequence Detail 8403 Not Applicable 
polypeptide OTTMUSP00000032602 VEGA | MGI Sequence Detail 767 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(488 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR015442 Integrin beta-8 subunit
InterPro IPR015812 Integrin beta subunit
InterPro IPR002369 Integrin beta subunit, N-terminal
InterPro IPR016201 Plexin-like fold
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000009144 integrin beta-8
References
(Earliest) J:47716 Nishimura SL, et al., Synaptic and glial localization of the integrin alphavbeta8 in mouse and rat brain. Brain Res. 1998 Apr 27;791(1-2):271-82
(Latest) J:211090 Lakhe-Reddy S, et al., Mesangial cell alphavbeta8-integrin regulates glomerular capillary integrity and repair. Am J Physiol Renal Physiol. 2014 Jun 15;306(12):F1400-9
All references(48)
Other
accession IDs
MGI:2445021

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory