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Itgb8
Gene Detail
 Symbol
Name
ID
Itgb8
integrin beta 8
MGI:1338035
Synonyms 4832412O06Rik
Feature Type protein coding gene
Genetic Map
Chromosome 12
63.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:119158022-119238802 bp, - strand
From VEGA annotation of GRCm38

  80781 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18567  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: integrin, beta subunit
Gene Tree: Itgb8

Human
homologs
Human Homolog ITGB8, integrin, beta 8
NCBI Gene ID 3696
neXtProt AC  NX_P26012
Human Chr (Location)  7p21.1; chr7:20330727-20415759 (+)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene either die before E11.5 as a result of circulatory abnormalities in the placenta or die within the first for days after birth and display intracerebral hemorrhaging.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cell adhesion, ganglioside metabolic process, ...
Component extracellular vesicular exosome, integral component of membrane, ...
Function receptor binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (222)    Tissues (53)    Images (35)
Theiler Stages: 15, 17, 20, 21, 23, 28
Assay TypeResults
RNA in situ 222
cDNA source data(47)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(47) cDNA(47)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000026449 (Evidence)
Ensembl Gene ModelENSMUSG00000025321 (Evidence)
Entrez Gene320910 (Evidence)
UniGene217000
DFCITC1589548, TC1597197, TC1602951
DoTSDT.91281973, DT.91313358, DT.91589329
NIA Mouse Gene IndexU034470
Consensus CDS ProjectCCDS36580.1
International Mouse Knockout Project StatusItgb8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026449 VEGA Gene Model | MGI Sequence Detail 80781 C57BL/6J ±  kb
transcript OTTMUST00000065410 VEGA | MGI Sequence Detail 8403 Not Applicable 
polypeptide OTTMUSP00000032602 VEGA | MGI Sequence Detail 767 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(488 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR015442 Integrin beta-8 subunit
InterPro IPR015812 Integrin beta subunit
InterPro IPR002369 Integrin beta subunit, N-terminal
InterPro IPR016201 Plexin-like fold
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000009144 integrin beta-8
References (Earliest) J:47716 Nishimura SL, et al., Synaptic and glial localization of the integrin alphavbeta8 in mouse and rat brain. Brain Res. 1998 Apr 27;791(1-2):271-82
(Latest) J:205525 Henderson NC, et al., Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec;19(12):1617-24
All references(48)
Other
accession IDs
MGI:2445021

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory